Zbtb16<sup>em1Ipcv</sup> (zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv) - Rat Genome Database

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Gene: Zbtb16em1Ipcv (zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv) Rattus norvegicus
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Symbol: Zbtb16em1Ipcv
Name: zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv
RGD ID: 150340624
Description: TALEN was used to target Zbtb16 (Plzf )in the SHR and one founder with a deletion of G at position 93 of the coding sequence (c.93delG) was identified. That deletion resulted in a frameshift downstream glycine 31 (p.Gly31fs). The frameshift mutation caused the incorporation of 20 aberrant amino acids downstream of the deleted G, followed by a stop codon.
ASSOCIATED WITH cardiac interstitial fibrosis; decreased body weight; decreased circulating cholesterol level
Type: allele  of Zbtb16  
Previously known as: Zbtb16^[em1Ipcv]
Is Marker For: Strains:   SHR-Zbtb16em1Ipcv+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Liška F, etal., Hypertension. 2017 Jun;69(6):1084-1091. doi: 10.1161/HYPERTENSIONAHA.116.08798. Epub 2017 Apr 10.

Genomics


Related Rat Strains
The following Strains have been annotated to Zbtb16em1Ipcv
SHR-Zbtb16em1Ipcv+/-    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information