Ngly1<sup>em1Ta</sup> (N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta) - Rat Genome Database

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Gene: Ngly1em1Ta (N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta) Rattus norvegicus
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Symbol: Ngly1em1Ta
Name: N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta
RGD ID: 149735565
Description: The mutations created by CRISPR/Cas9 contained 2.6 kb deletions in exon 11 and exon 12 and a 3' flanking region of the Ngly1. Two single-guideRNA (sgRNA) sequences targeting sites upstream (5'-sgRNA;5'-cagaggaattgtgatagtacagg-3')anddownstream(3'-sgRNA; 5'-ccagttattcataccatggtaaa-3') of the exon 11, exon 12 and a 3'flanking region of the ratNgly1genome, respectively.
ASSOCIATED WITH abnormal sciatic nerve morphology; abnormal thalamus morphology; axonal dystrophy; ASSOCIATED WITH NGLY1-deficiency
Type: allele  of Ngly1  
Previously known as: Ngly1^[em1Ta]
Is Marker For: Strains:   SD-Ngly1em1Ta-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems. Asahina M, etal., Hum Mol Genet. 2020 Jun 27;29(10):1635-1647. doi: 10.1093/hmg/ddaa059.

Genomics


Related Rat Strains
The following Strains have been annotated to Ngly1em1Ta


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-22 Ngly1em1Ta  N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta  Ngly1em1Ta    Name changed 629549 APPROVED