Ngly1<sup>em1Ta</sup> (N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta) - Rat Genome Database

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Gene: Ngly1em1Ta (N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta) Rattus norvegicus
Symbol: Ngly1em1Ta
Name: N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta
RGD ID: 149735565
Description: The mutations created by CRISPR/Cas9 contained 2.6 kb deletions in exon 11 and exon 12 and a 3' flanking region of the Ngly1. Two single-guideRNA (sgRNA) sequences targeting sites upstream (5'-sgRNA;5'-cagaggaattgtgatagtacagg-3')anddownstream(3'-sgRNA; 5'-ccagttattcataccatggtaaa-3') of the exon 11, exon 12 and a 3'flanking region of the ratNgly1genome, respectively.
ASSOCIATED WITH abnormal sciatic nerve morphology; abnormal thalamus morphology; axonal dystrophy; ASSOCIATED WITH NGLY1-deficiency
Type: allele  of Ngly1  
Previously known as: Ngly1^[em1Ta]
Is Marker For: Strains:   SD-Ngly1em1Ta-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems. Asahina M, etal., Hum Mol Genet. 2020 Jun 27;29(10):1635-1647. doi: 10.1093/hmg/ddaa059.


Related Rat Strains
The following Strains have been annotated to Ngly1em1Ta



Nucleotide Sequences

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-22 Ngly1em1Ta  N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta  Ngly1em1Ta    Name changed 629549 APPROVED