Wfs1<sup>em1Ptsn</sup> (wolframin ER transmembrane glycoprotein; ZFN induced mutant 1) - Rat Genome Database

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Gene: Wfs1em1Ptsn (wolframin ER transmembrane glycoprotein; ZFN induced mutant 1) Rattus norvegicus
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Symbol: Wfs1em1Ptsn
Name: wolframin ER transmembrane glycoprotein; ZFN induced mutant 1
RGD ID: 149735335
Description: This allele was created in embryos from Sprague-Dawley rats (Crl: CD(SD). A 27 amino acid deletion in exon 5 (aa212-238) was identified.
ASSOCIATED WITH abnormal brainstem morphology; decreased insulin secretion; decreased pancreatic beta cell mass; ASSOCIATED WITH cataract; diabetes mellitus; glucose intolerance
Type: allele  of Wfs1  
Previously known as: Wfs1em1; Wfs1^[em1Ptsn]
Is Marker For: Strains:   SD-Wfs1em1Ptsn  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.
2. Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome. Toots M, etal., Sci Rep. 2018 Jul 5;8(1):10183. doi: 10.1038/s41598-018-28314-z.

Genomics


Related Rat Strains
The following Strains have been annotated to Wfs1em1Ptsn
SD-Wfs1em1Ptsn    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-29 Wfs1em1Ptsn  wolframin ER transmembrane glycoprotein; ZFN induced mutant 1  Wfs1em1  wolframin ER transmembrane glycoprotein; ZFN induced mutant 1  Symbol changed 629549 APPROVED