PNP (purine nucleoside phosphorylase) - Rat Genome Database

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Gene: PNP (purine nucleoside phosphorylase) Sus scrofa
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Symbol: PNP
Name: purine nucleoside phosphorylase
RGD ID: 14297629
Description: ENCODES a protein that exhibits purine-nucleoside phosphorylase activity (ortholog); INVOLVED IN inosine catabolic process (ortholog); nucleobase-containing compound metabolic process (ortholog); positive regulation of alpha-beta T cell differentiation (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); extracellular region (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: NP; nucleoside phosphorylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,424,740 - 78,446,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,426,838 - 78,447,029 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,454,669 - 83,474,828 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q21-qterNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:3137847   PMID:3930426   PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
PNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,424,740 - 78,446,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,426,838 - 78,447,029 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,454,669 - 83,474,828 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q21-qterNCBI
PNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1420,468,954 - 20,477,089 (+)EnsemblGRCh38hg38GRCh38
GRCh381420,469,406 - 20,477,089 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371420,937,565 - 20,945,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,007,382 - 20,015,088 (+)NCBINCBI36hg18NCBI36
Build 341420,007,404 - 20,015,039NCBI
Celera14798,688 - 807,315 (+)NCBI
Cytogenetic Map14q11.2NCBI
HuRef141,059,149 - 1,067,777 (+)NCBIHuRef
CHM1_11420,938,918 - 20,947,545 (+)NCBICHM1_1
Pnp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,193,598 - 51,202,206 (+)NCBIGRCm39mm39
GRCm39 Ensembl1451,193,449 - 51,202,206 (+)Ensembl
GRCm381450,956,141 - 50,964,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,955,992 - 50,964,749 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,575,816 - 51,584,424 (+)NCBIGRCm37mm9NCBIm37
MGSCv361449,877,941 - 49,888,626 (+)NCBImm8
Cytogenetic Map14C1NCBI
Pnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21524,170,456 - 24,178,274 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1524,170,602 - 24,203,986 (+)Ensembl
Rnor_6.01527,875,883 - 27,883,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,875,911 - 27,883,350 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,708,604 - 31,716,285 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,929,784 - 26,937,434 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1524,490,737 - 24,498,388 (+)NCBICelera
Cytogenetic Map15p14NCBI
Pnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,290,244 - 1,298,068 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,290,816 - 1,299,553 (+)NCBIChiLan1.0ChiLan1.0
PNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11419,396,114 - 19,403,907 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,396,114 - 19,403,907 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0141,343,921 - 1,351,670 (+)NCBIMhudiblu_PPA_v0panPan3
PNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,808,454 - 17,815,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,808,461 - 17,815,676 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,291,391 - 18,298,968 (+)NCBI
ROS_Cfam_1.01518,065,565 - 18,073,165 (+)NCBI
UMICH_Zoey_3.11517,748,318 - 17,755,891 (+)NCBI
UNSW_CanFamBas_1.01517,802,993 - 17,810,552 (+)NCBI
UU_Cfam_GSD_1.01517,932,170 - 17,939,749 (+)NCBI
LOC101970144
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,705,514 - 77,711,679 (+)NCBI
SpeTri2.0NW_004936877686,539 - 692,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103231345
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12920,992,892 - 21,001,400 (+)NCBI
ChlSab1.1 Ensembl2920,993,280 - 21,001,606 (+)Ensembl
Vero_WHO_p1.0NW_02366605925,428,857 - 25,437,006 (-)NCBI
Pnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248254,688,662 - 4,699,912 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 2 2 4 2 2 3
Low 2 3 1 3 2 19 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002388   ⟹   ENSSSCP00000002333
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl778,424,740 - 78,446,997 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000055041   ⟹   ENSSSCP00000045142
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl778,424,740 - 78,434,781 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000062174   ⟹   ENSSSCP00000038118
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl778,426,845 - 78,446,994 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000085919   ⟹   ENSSSCP00000067180
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl778,424,740 - 78,431,685 (-)Ensembl
RefSeq Acc Id: XM_001929223   ⟹   XP_001929258
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1778,426,838 - 78,434,804 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013989064   ⟹   XP_013844518
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1778,426,838 - 78,447,029 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021099322   ⟹   XP_020954981
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1778,426,904 - 78,446,994 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001929258 (Get FASTA)   NCBI Sequence Viewer  
  XP_013844518 (Get FASTA)   NCBI Sequence Viewer  
  XP_020954981 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013844518   ⟸   XM_013989064
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_001929258   ⟸   XM_001929223
- Peptide Label: isoform X3
- UniProtKB: A0A287AM78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954981   ⟸   XM_021099322
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000002333   ⟸   ENSSSCT00000002388
RefSeq Acc Id: ENSSSCP00000045142   ⟸   ENSSSCT00000055041
RefSeq Acc Id: ENSSSCP00000038118   ⟸   ENSSSCT00000062174
RefSeq Acc Id: ENSSSCP00000067180   ⟸   ENSSSCT00000085919
Protein Domains
PNP_UDP_1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002135 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070019730 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002333 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000038118 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000045142 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000067180 UniProtKB/TrEMBL
  ENSSSCP00070032715 UniProtKB/TrEMBL
  ENSSSCP00070032722 UniProtKB/TrEMBL
  ENSSSCP00070032730 UniProtKB/TrEMBL
  ENSSSCP00070032736 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002388 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000055041 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000062174 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000085919 UniProtKB/TrEMBL
  ENSSSCT00070039063 UniProtKB/TrEMBL
  ENSSSCT00070039073 UniProtKB/TrEMBL
  ENSSSCT00070039084 UniProtKB/TrEMBL
  ENSSSCT00070039094 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1580 UniProtKB/TrEMBL
InterPro Nucleoside_phosphorylase_d UniProtKB/TrEMBL
  Nucleoside_phosphorylase_sf UniProtKB/TrEMBL
  Pur_Nuc_Pase_Ino/Guo-sp UniProtKB/TrEMBL
  Purine_phosphorylase UniProtKB/TrEMBL
  Purine_phosphorylase-2_CS UniProtKB/TrEMBL
KEGG Report ssc:100157138 UniProtKB/TrEMBL
NCBI Gene PNP ENTREZGENE
PANTHER PTHR11904 UniProtKB/TrEMBL
Pfam PNP_UDP_1 UniProtKB/TrEMBL
PIRSF PurNPase UniProtKB/TrEMBL
PROSITE PNP_MTAP_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53167 UniProtKB/TrEMBL
TIGRFAMs PNPH UniProtKB/TrEMBL
  PNPH-PUNA-XAPA UniProtKB/TrEMBL
UniProt A0A287A2Y1_PIG UniProtKB/TrEMBL
  A0A287AM78 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1URP2_PIG UniProtKB/TrEMBL
  A0A4X1UVI0_PIG UniProtKB/TrEMBL
  A0A4X1UWI4_PIG UniProtKB/TrEMBL
  A0A4X1UWK0_PIG UniProtKB/TrEMBL
  A0A5G2R9A1_PIG UniProtKB/TrEMBL
  F1S8H8_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91605 ENTREZGENE