CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) Sus scrofa
Analyze
Symbol: CAPZA1
Name: capping actin protein of muscle Z-line subunit alpha 1
RGD ID: 14296756
Description: ENCODES a protein that exhibits actin filament binding (ortholog); INVOLVED IN barbed-end actin filament capping (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH amenorrhea (ortholog); esophagus squamous cell carcinoma (ortholog); genetic disease (ortholog); FOUND IN brush border (ortholog); cell-cell junction (ortholog); cortical cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: capping actin protein of muscle Z-line alpha subunit 1; capping protein (actin filament) muscle Z-line, alpha 1; Capza; CP alpha1; F-actin capping protein alpha 1 subunit; F-actin capping protein subunit alpha 1; F-actin-capping protein subunit alpha-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4107,768,079 - 107,821,819 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14107,769,570 - 107,821,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,802,093 - 117,816,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7929586   PMID:14681463   PMID:17939027   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CAPZA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4107,768,079 - 107,821,819 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14107,769,570 - 107,821,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,802,093 - 117,816,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAPZA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381112,619,832 - 112,671,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1112,619,805 - 112,671,616 (+)EnsemblGRCh38hg38GRCh38
GRCh371113,162,454 - 113,214,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,963,598 - 113,015,764 (+)NCBINCBI36Build 36hg18NCBI36
Build 341112,874,508 - 112,926,276NCBI
Celera1111,392,601 - 111,444,712 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1111,020,785 - 111,072,609 (+)NCBIHuRef
CHM1_11113,276,956 - 113,329,490 (+)NCBICHM1_1
T2T-CHM13v2.01112,632,399 - 112,684,197 (+)NCBIT2T-CHM13v2.0
Capza1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393104,730,097 - 104,771,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3104,730,095 - 104,771,821 (-)EnsemblGRCm39 Ensembl
GRCm383104,822,781 - 104,864,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,822,779 - 104,864,505 (-)EnsemblGRCm38mm10GRCm38
MGSCv373104,625,703 - 104,667,423 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363104,950,989 - 104,992,450 (-)NCBIMGSCv36mm8
Celera3107,016,204 - 107,060,141 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.88NCBI
Capza1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,008,035 - 195,053,100 (-)NCBIGRCr8
mRatBN7.22192,319,696 - 192,364,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,319,702 - 192,364,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2199,914,034 - 199,959,128 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02197,786,335 - 197,831,387 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02192,603,278 - 192,648,331 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,305,748 - 207,350,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,305,752 - 207,350,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02226,722,331 - 226,767,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,080,802 - 200,125,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2184,785,867 - 184,830,762 (-)NCBICelera
Cytogenetic Map2q34NCBI
Capza1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543516,048,213 - 16,087,814 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543516,048,213 - 16,087,814 (+)NCBIChiLan1.0ChiLan1.0
CAPZA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,364,650 - 114,414,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11113,512,795 - 113,563,084 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,273,497 - 115,324,353 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11125,028,519 - 125,078,892 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,028,519 - 125,078,892 (-)Ensemblpanpan1.1panPan2
CAPZA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11762,900,062 - 62,948,164 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1762,901,422 - 62,948,084 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1762,413,590 - 62,462,117 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,073,256 - 64,122,047 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,042,029 - 64,121,389 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11762,807,805 - 62,856,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01762,866,060 - 62,914,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01763,625,654 - 63,674,438 (-)NCBIUU_Cfam_GSD_1.0
Capza1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,254,005 - 16,293,011 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366901,184,644 - 1,223,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPZA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12020,968,348 - 21,017,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2020,969,828 - 20,991,971 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603823,785,324 - 23,834,427 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capza1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247728,407,883 - 8,455,734 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CAPZA1
1044 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 23 2 3 3
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007421   ⟹   ENSSSCP00000007226
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4107,768,079 - 107,821,819 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000100459   ⟹   ENSSSCP00000078246
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4107,768,081 - 107,797,248 (-)Ensembl
RefSeq Acc Id: NM_001097454   ⟹   NP_001090923
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14107,769,570 - 107,821,806 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001090923   ⟸   NM_001097454
- UniProtKB: A0PFK5 (UniProtKB/TrEMBL),   A0A4X1T8I3 (UniProtKB/TrEMBL),   F6Q4Y6 (UniProtKB/TrEMBL),   A0A8D0JFQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000007226   ⟸   ENSSSCT00000007421
RefSeq Acc Id: ENSSSCP00000078246   ⟸   ENSSSCT00000100459


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006775 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005028813 UniProtKB/TrEMBL
  ENSSSCG00015065358 UniProtKB/TrEMBL
  ENSSSCG00025009980 UniProtKB/TrEMBL
  ENSSSCG00030055639 UniProtKB/TrEMBL
  ENSSSCG00035071826 UniProtKB/TrEMBL
  ENSSSCG00040028817 UniProtKB/TrEMBL
  ENSSSCG00045037598 UniProtKB/TrEMBL
  ENSSSCG00050020226 UniProtKB/TrEMBL
  ENSSSCG00055009451 UniProtKB/TrEMBL
  ENSSSCG00060073443 UniProtKB/TrEMBL
  ENSSSCG00065046383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070007119 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007421 ENTREZGENE
  ENSSSCT00000007421.5 UniProtKB/TrEMBL
  ENSSSCT00000100459.1 UniProtKB/TrEMBL
  ENSSSCT00005045653.1 UniProtKB/TrEMBL
  ENSSSCT00005045712.1 UniProtKB/TrEMBL
  ENSSSCT00005045763.1 UniProtKB/TrEMBL
  ENSSSCT00015087458.1 UniProtKB/TrEMBL
  ENSSSCT00015087589.1 UniProtKB/TrEMBL
  ENSSSCT00025013161.1 UniProtKB/TrEMBL
  ENSSSCT00030077549.1 UniProtKB/TrEMBL
  ENSSSCT00035097125.1 UniProtKB/TrEMBL
  ENSSSCT00035097141.1 UniProtKB/TrEMBL
  ENSSSCT00040038744.1 UniProtKB/TrEMBL
  ENSSSCT00045064962.1 UniProtKB/TrEMBL
  ENSSSCT00050027315.1 UniProtKB/TrEMBL
  ENSSSCT00050027339.1 UniProtKB/TrEMBL
  ENSSSCT00055018432.1 UniProtKB/TrEMBL
  ENSSSCT00060100755.1 UniProtKB/TrEMBL
  ENSSSCT00060100790.1 UniProtKB/TrEMBL
  ENSSSCT00065063458.1 UniProtKB/TrEMBL
  ENSSSCT00065063461.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCT00065063471.1 UniProtKB/TrEMBL
  ENSSSCT00070013725.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCT00070013751.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1140.60 UniProtKB/TrEMBL
  3.90.1150.210 UniProtKB/TrEMBL
  F-actin capping protein, alpha subunit UniProtKB/Swiss-Prot
  F-actin capping protein, beta subunit UniProtKB/Swiss-Prot
InterPro CapZ_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CapZ_alpha/beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CapZ_alpha/beta_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CapZ_alpha_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-actin_cap_asu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100037957 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene CAPZA1 ENTREZGENE
PANTHER F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA UniProtKB/Swiss-Prot
  F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10653 UniProtKB/TrEMBL
Pfam F-actin_cap_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FACTINCAPA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE F_ACTIN_CAPPING_A_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F_ACTIN_CAPPING_A_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF90096 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A4X1T8I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T8K1_PIG UniProtKB/TrEMBL
  A0A8D0JFQ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JKL8_PIG UniProtKB/TrEMBL
  A0A8D0PKY6_PIG UniProtKB/TrEMBL
  A0A8D1BAZ8_PIG UniProtKB/TrEMBL
  A0A8D1YVG7_PIG UniProtKB/TrEMBL
  A0A8W4FH92_PIG UniProtKB/TrEMBL
  A0PFK5 ENTREZGENE, UniProtKB/Swiss-Prot
  F6Q4Y6 ENTREZGENE
UniProt Secondary A0A5K1UD05 UniProtKB/TrEMBL
  F6Q4Y6 UniProtKB/Swiss-Prot
VGNC ID VGNC:86183 ENTREZGENE