SLC5A1 (solute carrier family 5 member 1) - Rat Genome Database
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Gene: SLC5A1 (solute carrier family 5 member 1) Sus scrofa
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Symbol: SLC5A1
Name: solute carrier family 5 member 1
RGD ID: 14295883
Description: ENCODES a protein that exhibits glucose transmembrane transporter activity (ortholog); INVOLVED IN intestinal absorption (ortholog); metanephros development (ortholog); PARTICIPATES IN lactose degradation pathway; sodium-glucose cotransporter mediated glucose transport pathway; trehalose degradation pathway; ASSOCIATED WITH genetic disease (ortholog); Glucose-Galactose Malabsorption (ortholog); Malabsorption Syndromes (ortholog); FOUND IN brush border (ortholog); brush border membrane (ortholog); cell-cell junction (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; bisphenol A; choline
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: high affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter; SGLT1; sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1
Orthologs:
Homo sapiens (human) : SLC5A1 (solute carrier family 5 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc5a1 (solute carrier family 5 (sodium/glucose cotransporter), member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc5a1 (solute carrier family 5 member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc5a1 (solute carrier family 5 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC5A1 (solute carrier family 5 member 1)
Canis lupus familiaris (dog) : SLC5A1 (solute carrier family 5 member 1)
Chlorocebus sabaeus (African green monkey) : SLC5A1 (solute carrier family 5 member 1)
Heterocephalus glaber (naked mole-rat) : Slc5a1 (solute carrier family 5 member 1)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1448,566,343 - 48,705,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11448,566,400 - 48,704,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,053,314 - 52,149,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21451,945,530 - 52,000,682 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2247068   PMID:14681463   PMID:26924216  


Genomics

Comparative Map Data
SLC5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1448,566,343 - 48,705,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11448,566,400 - 48,704,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,053,314 - 52,149,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21451,945,530 - 52,000,682 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2232,043,261 - 32,113,029 (+)EnsemblGRCh38hg38GRCh38
GRCh382232,043,050 - 32,113,029 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372232,439,019 - 32,509,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,769,259 - 30,836,645 (+)NCBINCBI36hg18NCBI36
Build 342230,763,812 - 30,831,199NCBI
Celera2216,239,500 - 16,309,474 (+)NCBI
Cytogenetic Map22q12.3ENTREZGENE
HuRef2215,394,743 - 15,464,755 (+)NCBIHuRef
CHM1_12232,398,482 - 32,468,466 (+)NCBICHM1_1
Slc5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,261,563 - 33,320,043 (+)NCBI
GRCm38533,104,219 - 33,162,699 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,104,219 - 33,162,870 (+)EnsemblGRCm38mm10GRCm38
MGSCv37533,446,868 - 33,505,348 (+)NCBIGRCm37mm9NCBIm37
MGSCv36533,421,091 - 33,479,554 (+)NCBImm8
Celera530,580,692 - 30,638,639 (+)NCBICelera
Cytogenetic Map5B1NCBI
Slc5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01482,910,448 - 82,975,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,909,981 - 82,975,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01483,595,212 - 83,660,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41483,311,232 - 83,370,657 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11483,313,626 - 83,376,968 (-)NCBI
Celera1476,469,843 - 76,534,501 (-)NCBICelera
Cytogenetic Map14q21NCBI
Slc5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554556,158,959 - 6,236,189 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554556,158,773 - 6,236,950 (+)NCBIChiLan1.0ChiLan1.0
SLC5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12230,924,169 - 30,992,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2230,924,169 - 30,992,046 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02213,070,853 - 13,140,948 (+)NCBIMhudiblu_PPA_v0panPan3
SLC5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2624,884,129 - 24,958,122 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12624,884,853 - 24,956,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
SLC5A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1914,928,160 - 15,002,498 (+)Ensembl
ChlSab1.11914,924,954 - 14,999,369 (+)NCBI
Slc5a1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247478,368,446 - 8,542,573 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 1
Low 5 3 2 18 2 2 1
Below cutoff 3 3 2 5 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010993   ⟹   ENSSSCP00000010706
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1448,628,224 - 48,705,841 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000052141   ⟹   ENSSSCP00000033188
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1448,566,343 - 48,705,841 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062401   ⟹   ENSSSCP00000034128
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1448,629,684 - 48,702,296 (+)Ensembl
RefSeq Acc Id: NM_001164021   ⟹   NP_001157493
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11448,628,225 - 48,704,145 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072101   ⟹   XP_020927760
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11448,566,400 - 48,704,144 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001157493 (Get FASTA)   NCBI Sequence Viewer  
  XP_020927760 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31122 (Get FASTA)   NCBI Sequence Viewer  
  AMN88558 (Get FASTA)   NCBI Sequence Viewer  
  P26429 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020927760   ⟸   XM_021072101
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001157493   ⟸   NM_001164021
- UniProtKB: A0A286ZRN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010706   ⟸   ENSSSCT00000010993
RefSeq Acc Id: ENSSSCP00000033188   ⟸   ENSSSCT00000052141
RefSeq Acc Id: ENSSSCP00000034128   ⟸   ENSSSCT00000062401


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010036 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070021818 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010706 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000033188 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000034128 UniProtKB/TrEMBL
  ENSSSCP00070036548 UniProtKB/TrEMBL
  ENSSSCP00070036560 UniProtKB/TrEMBL
  ENSSSCP00070036571 UniProtKB/TrEMBL
  ENSSSCP00070036586 UniProtKB/TrEMBL
  ENSSSCP00070036602 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010993 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000052141 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000062401 UniProtKB/TrEMBL
  ENSSSCT00070043427 UniProtKB/TrEMBL
  ENSSSCT00070043441 UniProtKB/TrEMBL
  ENSSSCT00070043453 UniProtKB/TrEMBL
  ENSSSCT00070043469 UniProtKB/TrEMBL
  ENSSSCT00070043485 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1730.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Na/Glc_symporter_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/solute_symporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/solute_symporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397113 UniProtKB/TrEMBL
NCBI Gene SLC5A1 ENTREZGENE
Pfam SSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NA_SOLUT_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_SOLUT_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_SOLUT_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs sss UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.161 ENTREZGENE
UniProt A0A140H1A0_PIG UniProtKB/TrEMBL
  A0A286ZNZ2_PIG UniProtKB/TrEMBL
  A0A286ZRN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V4S5_PIG UniProtKB/TrEMBL
  A0A4X1V4U2_PIG UniProtKB/TrEMBL
  A0A4X1V5B9_PIG UniProtKB/TrEMBL
  A0A4X1V5W6_PIG UniProtKB/TrEMBL
  F1RLV1_PIG UniProtKB/TrEMBL
  P26429 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:93140 ENTREZGENE