WDR6 (WD repeat domain 6) - Rat Genome Database

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Gene: WDR6 (WD repeat domain 6) Sus scrofa
Analyze
Symbol: WDR6
Name: WD repeat domain 6
RGD ID: 14295731
Description: ENCODES a protein that exhibits insulin receptor substrate binding (ortholog); INVOLVED IN G1 to G0 transition (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN COP9 signalosome (ortholog); protein-containing complex (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WD repeat-containing protein 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,642,325 - 31,651,361 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,642,207 - 31,651,367 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,885,702 - 34,894,484 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WDR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,642,325 - 31,651,361 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,642,207 - 31,651,367 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,885,702 - 34,894,484 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,007,391 - 49,015,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,007,062 - 49,015,953 (+)EnsemblGRCh38hg38GRCh38
GRCh37349,044,824 - 49,053,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,019,830 - 49,028,390 (+)NCBINCBI36Build 36hg18NCBI36
Build 34349,019,829 - 49,028,386NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,102,440 - 49,111,251 (+)NCBIHuRef
CHM1_1348,997,191 - 49,005,947 (+)NCBICHM1_1
T2T-CHM13v2.0349,035,431 - 49,043,991 (+)NCBIT2T-CHM13v2.0
Wdr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,449,510 - 108,455,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,449,510 - 108,455,938 (-)EnsemblGRCm39 Ensembl
GRCm389108,572,311 - 108,578,713 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,572,311 - 108,578,739 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,474,644 - 108,481,001 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,430,416 - 108,436,869 (-)NCBIMGSCv36mm8
Celera9108,183,554 - 108,189,907 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.51NCBI
Wdr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,146,608 - 118,153,024 (-)NCBIGRCr8
mRatBN7.28109,268,079 - 109,274,504 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,268,079 - 109,274,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,886,331 - 114,892,761 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,085,665 - 113,092,095 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,928,305 - 110,934,735 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,358,345 - 117,364,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,358,787 - 117,366,096 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,702,848 - 116,709,264 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,618,341 - 113,624,757 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,637,801 - 113,638,950 (-)NCBI
Celera8108,563,853 - 108,570,269 (-)NCBICelera
Cytogenetic Map8q32NCBI
Wdr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,028,466 - 1,039,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,029,857 - 1,039,020 (+)NCBIChiLan1.0ChiLan1.0
WDR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,986,031 - 48,994,763 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,990,824 - 48,999,529 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,931,669 - 48,940,591 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,013,570 - 50,022,034 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,013,708 - 50,021,367 (+)Ensemblpanpan1.1panPan2
WDR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,148,262 - 40,157,770 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,148,928 - 40,157,650 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,066,440 - 40,075,980 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,505,441 - 40,515,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,505,441 - 40,515,188 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,872,036 - 39,881,691 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,275,813 - 40,285,364 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,555,322 - 40,564,865 (-)NCBIUU_Cfam_GSD_1.0
Wdr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,971,461 - 63,980,835 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529730,716 - 745,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529731,958 - 741,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,407,421 - 10,416,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,407,703 - 10,415,633 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,665,972 - 156,675,272 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,055,610 - 3,063,153 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,058,947 - 3,063,709 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WDR6
131 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 6 2
Low 10 4 5 2 17 2 1 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021070645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000047935   ⟹   ENSSSCP00000056522
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,642,325 - 31,651,361 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062590   ⟹   ENSSSCP00000058016
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,627,240 - 31,651,361 (+)Ensembl
RefSeq Acc Id: XM_021070645   ⟹   XP_020926304
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,642,207 - 31,651,367 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020926304   ⟸   XM_021070645
- UniProtKB: A0A287BKB6 (UniProtKB/TrEMBL),   A0A4X1SXG9 (UniProtKB/TrEMBL),   A0A8D2AAN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000058016   ⟸   ENSSSCT00000062590
RefSeq Acc Id: ENSSSCP00000056522   ⟸   ENSSSCT00000047935


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011369 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005045482 UniProtKB/TrEMBL
  ENSSSCG00025051710 UniProtKB/TrEMBL
  ENSSSCG00030051015 UniProtKB/TrEMBL
  ENSSSCG00035076059 UniProtKB/TrEMBL
  ENSSSCG00045031841 UniProtKB/TrEMBL
  ENSSSCG00050036607 UniProtKB/TrEMBL
  ENSSSCG00055015583 UniProtKB/TrEMBL
  ENSSSCG00060054589 UniProtKB/TrEMBL
  ENSSSCG00065078692 UniProtKB/TrEMBL
  ENSSSCG00070005071 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000047935 ENTREZGENE
  ENSSSCT00000047935.3 UniProtKB/TrEMBL
  ENSSSCT00005073569.1 UniProtKB/TrEMBL
  ENSSSCT00005073586.1 UniProtKB/TrEMBL
  ENSSSCT00005073593.1 UniProtKB/TrEMBL
  ENSSSCT00005073597.1 UniProtKB/TrEMBL
  ENSSSCT00025070948.1 UniProtKB/TrEMBL
  ENSSSCT00030071162.1 UniProtKB/TrEMBL
  ENSSSCT00035103501.1 UniProtKB/TrEMBL
  ENSSSCT00045054695.1 UniProtKB/TrEMBL
  ENSSSCT00050049280.1 UniProtKB/TrEMBL
  ENSSSCT00055031224.1 UniProtKB/TrEMBL
  ENSSSCT00055031357.1 UniProtKB/TrEMBL
  ENSSSCT00055031422.1 UniProtKB/TrEMBL
  ENSSSCT00055031535.1 UniProtKB/TrEMBL
  ENSSSCT00060074344.1 UniProtKB/TrEMBL
  ENSSSCT00065109297.1 UniProtKB/TrEMBL
  ENSSSCT00065109305.1 UniProtKB/TrEMBL
  ENSSSCT00065109310.1 UniProtKB/TrEMBL
  ENSSSCT00065109320.1 UniProtKB/TrEMBL
  ENSSSCT00070009624.1 UniProtKB/TrEMBL
Gene3D-CATH YVTN repeat-like/Quinoprotein amine dehydrogenase UniProtKB/TrEMBL
InterPro Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene WDR6 ENTREZGENE
PANTHER WD REPEAT PROTEIN UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 6 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP Quinoprotein alcohol dehydrogenase-like UniProtKB/TrEMBL
  WD40 repeat-like UniProtKB/TrEMBL
UniProt A0A287BKB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SXG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2AAN5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94931 ENTREZGENE