CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2) - Rat Genome Database

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Gene: CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2) Sus scrofa
Analyze
Symbol: CHAC2
Name: ChaC glutathione specific gamma-glutamylcyclotransferase 2
RGD ID: 14295481
Description: ENCODES a protein that exhibits gamma-glutamylcyclotransferase activity (inferred); glutathione specific gamma-glutamylcyclotransferase activity (inferred); lyase activity (inferred); INVOLVED IN glutathione catabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ChaC cation transport regulator homolog 2; putative glutathione-specific gamma-glutamylcyclotransferase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl387,405,978 - 87,416,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1387,405,937 - 87,417,268 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,565,352 - 92,575,558 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl387,405,978 - 87,416,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1387,405,937 - 87,417,268 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,565,352 - 92,575,558 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38253,767,783 - 53,775,196 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl253,767,804 - 53,775,196 (+)EnsemblGRCh38hg38GRCh38
GRCh37253,994,920 - 54,002,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36253,848,433 - 53,855,791 (+)NCBINCBI36Build 36hg18NCBI36
Celera253,835,783 - 53,843,141 (+)NCBICelera
Cytogenetic Map2p16.2NCBI
HuRef253,729,267 - 53,736,626 (+)NCBIHuRef
CHM1_1253,925,914 - 53,933,272 (+)NCBICHM1_1
T2T-CHM13v2.0253,763,988 - 53,771,398 (+)NCBIT2T-CHM13v2.0
Chac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,926,707 - 30,936,365 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,926,707 - 30,936,350 (-)EnsemblGRCm39 Ensembl
GRCm381130,976,707 - 30,986,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,976,707 - 30,986,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv371130,876,709 - 30,886,365 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,876,724 - 30,886,334 (-)NCBIMGSCv36mm8
Celera1133,385,672 - 33,395,218 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.2NCBI
Chac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,921,669 - 108,929,215 (-)NCBIGRCr8
mRatBN7.214104,720,754 - 104,728,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,720,758 - 104,728,301 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14109,032,788 - 109,040,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,259,770 - 110,267,198 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,732,201 - 106,739,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014115,383,906 - 115,391,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,383,910 - 115,391,652 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014115,005,083 - 115,047,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414112,082,173 - 112,122,592 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114112,141,673 - 112,148,939 (-)NCBI
Celera14103,558,180 - 103,565,612 (-)NCBICelera
Cytogenetic Map14q22NCBI
Chac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544119,502,383 - 19,509,736 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544119,502,389 - 19,509,736 (+)NCBIChiLan1.0ChiLan1.0
CHAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21272,583,066 - 72,591,548 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A72,587,032 - 72,594,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A53,911,057 - 53,918,620 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A54,823,066 - 54,830,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A54,823,067 - 54,830,474 (+)Ensemblpanpan1.1panPan2
CHAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,790,670 - 54,799,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1054,790,942 - 54,798,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1054,742,510 - 54,751,696 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01055,789,281 - 55,798,477 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1055,789,595 - 55,797,618 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11055,482,583 - 55,491,741 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,768,555 - 55,777,742 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,055,614 - 56,064,806 (+)NCBIUU_Cfam_GSD_1.0
Chac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629228,236,736 - 28,246,775 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936491324,524 - 336,601 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936491324,540 - 336,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11453,205,940 - 53,214,439 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1453,203,361 - 53,213,885 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604558,493,585 - 58,501,099 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248337,937,183 - 7,945,755 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248337,937,152 - 7,946,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CHAC2
328 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000045031   ⟹   ENSSSCP00000051521
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl387,405,978 - 87,416,207 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053708   ⟹   ENSSSCP00000034560
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl387,406,030 - 87,416,260 (-)Ensembl
RefSeq Acc Id: XM_003125149   ⟹   XP_003125197
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1387,405,937 - 87,417,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021088232   ⟹   XP_020943891
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1387,405,937 - 87,417,268 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020943891   ⟸   XM_021088232
- Peptide Label: isoform X2
- UniProtKB: A0A286ZSD1 (UniProtKB/TrEMBL),   A0A4X1W6T0 (UniProtKB/TrEMBL),   A0A8D0Q0A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003125197   ⟸   XM_003125149
- Peptide Label: isoform X1
- UniProtKB: A0A287B4W3 (UniProtKB/TrEMBL),   A0A4X1WC75 (UniProtKB/TrEMBL),   A0A8D0YTN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000051521   ⟸   ENSSSCT00000045031
RefSeq Acc Id: ENSSSCP00000034560   ⟸   ENSSSCT00000053708


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037577 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005045015 UniProtKB/TrEMBL
  ENSSSCG00015074533 UniProtKB/TrEMBL
  ENSSSCG00025076897 UniProtKB/TrEMBL
  ENSSSCG00030028323 UniProtKB/TrEMBL
  ENSSSCG00035016607 UniProtKB/TrEMBL
  ENSSSCG00040056763 UniProtKB/TrEMBL
  ENSSSCG00045025483 UniProtKB/TrEMBL
  ENSSSCG00050039068 UniProtKB/TrEMBL
  ENSSSCG00055023974 UniProtKB/TrEMBL
  ENSSSCG00060053658 UniProtKB/TrEMBL
  ENSSSCG00065042768 UniProtKB/TrEMBL
  ENSSSCG00070030390 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000045031 ENTREZGENE
  ENSSSCT00000045031.3 UniProtKB/TrEMBL
  ENSSSCT00000053708 ENTREZGENE
  ENSSSCT00000053708.2 UniProtKB/TrEMBL
  ENSSSCT00005072627.1 UniProtKB/TrEMBL
  ENSSSCT00005072633.1 UniProtKB/TrEMBL
  ENSSSCT00015100271.1 UniProtKB/TrEMBL
  ENSSSCT00015100361.1 UniProtKB/TrEMBL
  ENSSSCT00025106658.1 UniProtKB/TrEMBL
  ENSSSCT00025106666.1 UniProtKB/TrEMBL
  ENSSSCT00030039601.1 UniProtKB/TrEMBL
  ENSSSCT00030039609.1 UniProtKB/TrEMBL
  ENSSSCT00035021237.1 UniProtKB/TrEMBL
  ENSSSCT00035021241.1 UniProtKB/TrEMBL
  ENSSSCT00040076846.1 UniProtKB/TrEMBL
  ENSSSCT00040076883.1 UniProtKB/TrEMBL
  ENSSSCT00045043427.1 UniProtKB/TrEMBL
  ENSSSCT00045043483.1 UniProtKB/TrEMBL
  ENSSSCT00050052697.1 UniProtKB/TrEMBL
  ENSSSCT00050052699.1 UniProtKB/TrEMBL
  ENSSSCT00055047205.1 UniProtKB/TrEMBL
  ENSSSCT00055047254.1 UniProtKB/TrEMBL
  ENSSSCT00060073053.1 UniProtKB/TrEMBL
  ENSSSCT00060073059.1 UniProtKB/TrEMBL
  ENSSSCT00065058465.1 UniProtKB/TrEMBL
  ENSSSCT00065058468.1 UniProtKB/TrEMBL
  ENSSSCT00070061158.1 UniProtKB/TrEMBL
  ENSSSCT00070061159.1 UniProtKB/TrEMBL
Gene3D-CATH Gamma-glutamyl cyclotransferase-like UniProtKB/TrEMBL
InterPro ChaC UniProtKB/TrEMBL
  GGCT-like UniProtKB/TrEMBL
  GGCT-like_sf UniProtKB/TrEMBL
KEGG Report ssc:100517647 UniProtKB/TrEMBL
NCBI Gene CHAC2 ENTREZGENE
PANTHER GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2 UniProtKB/TrEMBL
  PTHR12192 UniProtKB/TrEMBL
Pfam ChaC UniProtKB/TrEMBL
Superfamily-SCOP SSF110857 UniProtKB/TrEMBL
UniProt A0A286ZSD1 ENTREZGENE
  A0A287B4W3 ENTREZGENE
  A0A4X1W6T0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WC75 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Q0A0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0YTN7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A286ZSD1 UniProtKB/TrEMBL
  A0A287B4W3 UniProtKB/TrEMBL
VGNC ID VGNC:86620 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-25 CHAC2  ChaC glutathione specific gamma-glutamylcyclotransferase 2  CHAC2  ChaC cation transport regulator homolog 2  Symbol and/or name change 5135510 APPROVED