CDKN2D (cyclin dependent kinase inhibitor 2D)

Gene: CDKN2D (cyclin dependent kinase inhibitor 2D) Sus scrofa

Analyze

Symbol:

CDKN2D

Name:

cyclin dependent kinase inhibitor 2D

RGD ID:

14286627

Description:

ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); protein kinase binding (inferred); INVOLVED IN negative regulation of cell cycle G1/S phase transition (ortholog); sensory perception of sound (ortholog); PARTICIPATES IN G1/S transition pathway; ASSOCIATED WITH genetic disease (ortholog); Stomach Neoplasms (ortholog); FOUND IN cyclin D2-CDK4 complex (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cyclin-dependent kinase 4 inhibitor D

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	69,337,432 - 69,339,933 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	69,337,428 - 69,339,998 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	69,723,120 - 69,725,688 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagic cell death (IEA)

DNA synthesis involved in DNA repair (IEA)

negative regulation of cell cycle G1/S phase transition (IEA,ISO)

negative regulation of cell growth (IEA)

negative regulation of cell population proliferation (IEA)

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (IEA)

regulation of G1/S transition of mitotic cell cycle (IEA)

regulation of transcription by RNA polymerase II (IBA)

response to retinoic acid (IEA)

response to UV (IEA)

response to vitamin D (IEA)

sensory perception of sound (IEA,ISO)

Cellular Component

cyclin D2-CDK4 complex (IEA)

cytoplasm (IEA)

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IBA,IEA)

Molecular Function

cyclin-dependent protein serine/threonine kinase inhibitor activity (IEA)

protein binding (ISO)

protein kinase binding (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

G1/S transition pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CDKN2D
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	69,337,432 - 69,339,933 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	69,337,428 - 69,339,998 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	69,723,120 - 69,725,688 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDKN2D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	10,566,460 - 10,568,979 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	10,566,460 - 10,569,059 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	10,677,136 - 10,679,655 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	10,538,138 - 10,540,655 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	10,538,138 - 10,540,655	NCBI
Celera	19	10,571,882 - 10,574,399 (-)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	10,255,057 - 10,257,571 (-)	NCBI		HuRef
CHM1_1	19	10,677,886 - 10,680,400 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	10,692,920 - 10,695,436 (-)	NCBI		T2T-CHM13v2.0

Cdkn2d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	21,199,759 - 21,202,553 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	21,199,706 - 21,202,703 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	21,288,459 - 21,291,421 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	21,288,410 - 21,291,407 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	21,092,907 - 21,095,653 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	21,038,865 - 21,041,421 (-)	NCBI		MGSCv36	mm8
Celera	9	18,557,588 - 18,560,334 (-)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	7.76	NCBI

Cdkn2d
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	28,108,036 - 28,110,809 (-)	NCBI		GRCr8
mRatBN7.2	8	19,831,874 - 19,834,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	19,831,866 - 19,834,674 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	23,851,704 - 23,854,497 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,149,553 - 22,152,346 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	20,061,563 - 20,064,328 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Celera	8	21,223,465 - 21,226,230 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

Cdkn2d
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	1,755,878 - 1,757,037 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	1,755,280 - 1,759,125 (-)	NCBI	ChiLan1.0	ChiLan1.0

CDKN2D
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	15,484,899 - 15,487,580 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	14,483,496 - 14,486,148 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	10,118,302 - 10,120,957 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	10,780,683 - 10,782,829 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

CDKN2D
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	50,607,382 - 50,609,929 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	50,607,674 - 50,609,482 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	50,479,638 - 50,482,207 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	51,130,501 - 51,133,072 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	51,130,778 - 51,133,070 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	50,337,348 - 50,339,917 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	50,765,427 - 50,767,996 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	51,006,476 - 51,009,047 (+)	NCBI		UU_Cfam_GSD_1.0

Cdkn2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	209,511,523 - 209,514,098 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936659	840,602 - 843,078 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDKN2D
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	9,579,648 - 9,582,249 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	9,579,470 - 9,582,101 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	10,408,971 - 10,411,618 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdkn2d
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	2,634,654 - 2,636,701 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	2,634,347 - 2,637,123 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CDKN2D
27 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium						5
Low	10	4	3	5	2	18	2	2	3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005654859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK237515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK394291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU993813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01123616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000044779 ⟹ ENSSSCP00000033946

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	69,337,432 - 69,339,933 (-)	Ensembl

RefSeq Acc Id:

XM_005654859 ⟹ XP_005654916

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	69,337,428 - 69,339,998 (-)	NCBI

Sequence:

show sequence

ATGCTGCTGGGCTACAACGTAGCAAGTTCATAAGAAAACAAATCCGCGGCGCTCGGGGGCGGGG
CCCCGAGCGTGGTGGCTCCGCCCCCTGGCGGCCGGCTCGGCTACTGCGGCCGCGGAGTCGGTTC
AGAACAGACCCCGCCCGTCGAGGAGGAGGGAGGGCCGCCAGTATCGATATGCTGCTAGAGGAGG
TCTGCGCCGGCGACCGGCTGAGCGGAGCGGCGGCCCGGGGCGACGTGCAGGAGGTGCGCCGCCT
TCTGCACCGCGAACTGGTGCACCCCGACGTCCTGAACCGCTTTGGCAAGACGGCGCTGCAGGTC
ATGATGTTTGGCAGCCCCACCATCGCCCAGGAGCTCCTGAAACAAGGTGCCAGCCCCAATGTCC
AGGATGCTTCCGGCACCACTCCGGCCCACGATGCAGCCCGTACTGGATTCCTTGACACCCTGAA
AGTGTTGGTAGAGCACGGCGCTGATGTCAATGCACCTGATGGCACCGGGGCACTCCCCATTCAT
CTGGCTGTGAGAGAGGGCCACACCTCTGTGGTCAGCTTCCTGGCTGCTGAATCTGATCTCCATC
ACAGGGACGCCAGGGGGCTTACACCCCTGGAGCTGGCAAGGGGGAGAGGTGCTCAGGATCTCAT
GGACATACTACAGCGGCACACAGTGGCACCACTGTGACCTGGGGCCACCCAGTCCAGCAACAGG
ACCCGGCTGGGTTCTGTGTCAGAAGAGAAGGGAAGAAACACTTTCTCCCTTAGCTCCTCCTGCC
CACTGCCGAGGGGCACAAGTTTGTGGCTTGTTGGTGTTGATTTCTGGGGTGTGTGTGTTTGAGG
TGCATTTCTCATTTTTTTTCCTCTCACCCCTTTTGGTGTATTGGGCAGAGAAGGGCTCCTGCAG
GCAACAGCCACCTAAACGGTTCAGTTTCCTCCACCCCCCAGACTGCTGGGACTACAGACAAGTC
CCAAGGGCAGAGCGTTTAAAGCCCTAGCTCCAGAGTGAGGTCATTCCTTCCAAGGCTCCTGGAA
CCTGTCGACCTTGGCCAGCTATACCCAGAGCTAGACCTCAAGTGTGCACACTGCTTTCGGGCAT
GGGGGAGGGGGGTGTTCCAAATCAGTAAAAGGGTAGTATGAGTTCATTCATATTTTGTTTAAAA
GCTTGTTTTCCAGTCCCTTGTACAGCGTTAACACATTCTATTTATTAAGCTTTATGGAAAAAAT
TGTTGTGTGTGTAATTTAATGTTTTTACCCATTAAATTAAGACTTGTGCATGATCATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005654916	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000033946
	ENSSSCP00000033946.1
	ENSSSCP00015041440.1
	ENSSSCP00025047378.1
	ENSSSCP00030017215.1
	ENSSSCP00035012698.1
	ENSSSCP00040001885.1
	ENSSSCP00045027785.1
	ENSSSCP00050032388.1
	ENSSSCP00055044035.1
	ENSSSCP00060020220.1
	ENSSSCP00065048855.1
	ENSSSCP00070038228.1

RefSeq Acc Id:	XP_005654916 ⟸ XM_005654859
- UniProtKB:	F1S492 (UniProtKB/TrEMBL), A0A4X1V9I8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLEEVCAGDRLSGAAARGDVQEVRRLLHRELVHPDVLNRFGKTALQVMMFGSPTIAQELLKQG ASPNVQDASGTTPAHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVREGHTSVVSFLAA ESDLHHRDARGLTPLELARGRGAQDLMDILQRHTVAPL hide sequence

RefSeq Acc Id:

ENSSSCP00000033946 ⟸ ENSSSCT00000044779

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000013643	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015074420	UniProtKB/TrEMBL
	ENSSSCG00025076431	UniProtKB/TrEMBL
	ENSSSCG00030026890	UniProtKB/TrEMBL
	ENSSSCG00035024526	UniProtKB/TrEMBL
	ENSSSCG00040004125	UniProtKB/TrEMBL
	ENSSSCG00045023352	UniProtKB/TrEMBL
	ENSSSCG00050055019	UniProtKB/TrEMBL
	ENSSSCG00055027885	UniProtKB/TrEMBL
	ENSSSCG00060034814	UniProtKB/TrEMBL
	ENSSSCG00065078571	UniProtKB/TrEMBL
	ENSSSCG00070022803	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000044779	ENTREZGENE
	ENSSSCT00000044779.3	UniProtKB/TrEMBL
	ENSSSCT00015100206.1	UniProtKB/TrEMBL
	ENSSSCT00025105846.1	UniProtKB/TrEMBL
	ENSSSCT00030037583.1	UniProtKB/TrEMBL
	ENSSSCT00035032255.1	UniProtKB/TrEMBL
	ENSSSCT00040005301.1	UniProtKB/TrEMBL
	ENSSSCT00045039900.1	UniProtKB/TrEMBL
	ENSSSCT00050075065.1	UniProtKB/TrEMBL
	ENSSSCT00055055190.1	UniProtKB/TrEMBL
	ENSSSCT00060047199.1	UniProtKB/TrEMBL
	ENSSSCT00065108973.1	UniProtKB/TrEMBL
	ENSSSCT00070045353.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
KEGG Report	ssc:100525560	UniProtKB/TrEMBL
NCBI Gene	CDKN2D	ENTREZGENE
PANTHER	ANK_REP_REGION DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	CYCLIN-DEPENDENT KINASE 4 INHIBITOR D	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
SMART	ANK	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48403	UniProtKB/TrEMBL
UniProt	A0A4X1V9I8	ENTREZGENE, UniProtKB/TrEMBL
	F1S492	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:99617	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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