SHAS2 (hyaluronan synthase 2) - Rat Genome Database

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Gene: SHAS2 (hyaluronan synthase 2) Sus scrofa
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Symbol: SHAS2
Name: hyaluronan synthase 2
RGD ID: 14286470
Description: ENCODES a protein that exhibits hyaluronan synthase activity (ortholog); INVOLVED IN bone morphogenesis (ortholog); estrous cycle (ortholog); hyaluronan biosynthetic process (ortholog); ASSOCIATED WITH Cardiomegaly (ortholog); diabetes insipidus (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle (ortholog); plasma membrane (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; deoxynivalenol; zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Has2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl417,596,492 - 17,615,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1417,583,154 - 17,613,524 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2418,458,703 - 18,489,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:29141921   PMID:30032202  


Genomics

Comparative Map Data
SHAS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl417,596,492 - 17,615,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1417,583,154 - 17,613,524 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2418,458,703 - 18,489,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388121,612,116 - 121,641,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8121,612,116 - 121,641,440 (-)EnsemblGRCh38hg38GRCh38
GRCh378122,624,356 - 122,653,680 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368122,694,719 - 122,722,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 348122,694,720 - 122,722,811NCBI
Celera8118,814,049 - 118,842,240 (-)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8117,950,042 - 117,978,400 (-)NCBIHuRef
CHM1_18122,665,454 - 122,693,813 (-)NCBICHM1_1
T2T-CHM13v2.08122,742,348 - 122,771,670 (-)NCBIT2T-CHM13v2.0
Has2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391556,529,023 - 56,557,942 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1556,529,023 - 56,557,935 (-)EnsemblGRCm39 Ensembl
GRCm381556,665,627 - 56,694,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1556,665,627 - 56,694,539 (-)EnsemblGRCm38mm10GRCm38
MGSCv371556,497,182 - 56,526,101 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361556,495,712 - 56,524,587 (-)NCBIMGSCv36mm8
Celera1558,189,438 - 58,218,384 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1523.31NCBI
Has2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8790,002,929 - 90,028,933 (-)NCBIGRCr8
mRatBN7.2788,113,326 - 88,139,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl788,113,326 - 88,128,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx789,997,804 - 90,023,812 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0792,199,040 - 92,225,048 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0792,001,677 - 92,027,674 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0796,438,046 - 96,464,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl796,438,046 - 96,464,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0797,055,458 - 97,081,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4793,230,135 - 93,256,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1793,264,364 - 93,290,369 (-)NCBI
Celera784,901,996 - 84,927,998 (-)NCBICelera
RH 3.4 Map7607.6RGD
Cytogenetic Map7q33NCBI
Has2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955540593,316 - 609,865 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955540593,316 - 609,760 (-)NCBIChiLan1.0ChiLan1.0
HAS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27139,047,958 - 139,077,299 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18114,560,317 - 114,589,433 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08118,313,186 - 118,342,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18121,073,419 - 121,101,450 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8121,072,154 - 121,089,365 (-)Ensemblpanpan1.1panPan2
HAS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11320,310,946 - 20,342,647 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1320,309,872 - 20,341,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1320,341,670 - 20,392,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01320,646,614 - 20,697,736 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1320,647,874 - 20,664,774 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11320,379,420 - 20,429,051 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01320,482,900 - 20,533,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01320,720,804 - 20,770,669 (-)NCBIUU_Cfam_GSD_1.0
Has2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530317,991,598 - 18,018,681 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647025,418,063 - 25,444,634 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647025,418,069 - 25,443,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18116,199,516 - 116,228,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8116,200,799 - 116,228,788 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603924,042,921 - 24,072,107 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Has2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473533,095,515 - 33,121,237 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473533,095,441 - 33,121,030 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SHAS2
930 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 2
Low 8 4 3 2 5 2 2
Below cutoff 3 16 1 1

Sequence


RefSeq Acc Id: ENSSSCT00000006575   ⟹   ENSSSCP00000006400
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl417,596,492 - 17,615,480 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000046958   ⟹   ENSSSCP00000052747
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl417,655,948 - 17,675,586 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089445   ⟹   ENSSSCP00000068296
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl417,596,472 - 17,673,841 (+)Ensembl
RefSeq Acc Id: NM_214053   ⟹   NP_999218
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1417,583,154 - 17,613,524 (+)NCBI
Sequence:
RefSeq Acc Id: NP_999218   ⟸   NM_214053
- UniProtKB: Q8SQ70 (UniProtKB/TrEMBL),   A0A4X1T2B0 (UniProtKB/TrEMBL),   F1S290 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000068296   ⟸   ENSSSCT00000089445
RefSeq Acc Id: ENSSSCP00000006400   ⟸   ENSSSCT00000006575
RefSeq Acc Id: ENSSSCP00000052747   ⟸   ENSSSCT00000046958


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005992 Ensembl
  ENSSSCG00000057079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015023468 UniProtKB/TrEMBL
  ENSSSCG00065019563 UniProtKB/TrEMBL
  ENSSSCG00070006266 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006575 ENTREZGENE
  ENSSSCT00000006575.5 UniProtKB/TrEMBL
  ENSSSCT00015031165.1 UniProtKB/TrEMBL
  ENSSSCT00065026056.1 UniProtKB/TrEMBL
  ENSSSCT00070011993.1 UniProtKB/TrEMBL
InterPro Nucleotide-diphossugar_trans UniProtKB/TrEMBL
KEGG Report ssc:397120 UniProtKB/TrEMBL
NCBI Gene SHAS2 ENTREZGENE
PANTHER HYALURONAN SYNTHASE UniProtKB/TrEMBL
  PTHR22913:SF7 UniProtKB/TrEMBL
Pfam Chitin_synth_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A0A4X1T2B0 ENTREZGENE, UniProtKB/TrEMBL
  F1S290 ENTREZGENE, UniProtKB/TrEMBL
  Q8SQ70 ENTREZGENE, UniProtKB/TrEMBL