PRKD2 (protein kinase D2) - Rat Genome Database
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Gene: PRKD2 (protein kinase D2) Sus scrofa
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Symbol: PRKD2
Name: protein kinase D2
RGD ID: 14285575
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to vascular endothelial growth factor stimulus (ortholog); intracellular signal transduction (ortholog); positive regulation of DNA biosynthetic process (ortholog); ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); polycystic ovary syndrome (ortholog); Walker-Warburg syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine/threonine-protein kinase D2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,559,393 - 52,599,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,559,066 - 52,599,174 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,880,007 - 47,919,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell death  (IEA)
cellular response to vascular endothelial growth factor stimulus  (ISO)
intracellular signal transduction  (ISO)
peptidyl-serine phosphorylation  (IEA)
peptidyl-threonine phosphorylation  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of CREB transcription factor activity  (IEA)
positive regulation of DNA biosynthetic process  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (IEA)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (IEA)
positive regulation of histone deacetylase activity  (IEA)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IEA)
protein autophosphorylation  (IEA)
protein kinase D signaling  (IBA)
protein phosphorylation  (ISO)
T cell receptor signaling pathway  (IEA)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA)
membrane  (IEA)
nucleoplasm  (IEA)
nucleus  (ISO)

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
PRKD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,559,393 - 52,599,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,559,066 - 52,599,174 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,880,007 - 47,919,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1946,674,275 - 46,717,127 (-)EnsemblGRCh38hg38GRCh38
GRCh381946,674,316 - 46,717,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371947,177,573 - 47,220,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,869,413 - 51,912,224 (-)NCBINCBI36hg18NCBI36
Build 341951,869,412 - 51,911,506NCBI
Celera1943,981,103 - 44,023,914 (-)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1943,602,696 - 43,645,312 (-)NCBIHuRef
CHM1_11947,179,449 - 47,222,284 (-)NCBICHM1_1
Prkd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,576,827 - 16,604,386 (+)NCBIGRCm39mm39
GRCm39 Ensembl716,576,827 - 16,604,389 (+)Ensembl
GRCm38716,842,902 - 16,870,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,842,902 - 16,870,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,428,414 - 17,455,810 (+)NCBIGRCm37mm9NCBIm37
MGSCv36716,001,587 - 16,028,983 (+)NCBImm8
Celera714,041,053 - 14,076,870 (+)NCBICelera
Cytogenetic Map7A2NCBI
Prkd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,513,625 - 77,542,386 (+)NCBI
Rnor_6.0 Ensembl178,767,911 - 78,796,231 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0178,767,911 - 78,796,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0180,015,106 - 80,043,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,168,290 - 77,197,277 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1177,246,400 - 77,275,388 (+)NCBI
Celera171,999,137 - 72,027,468 (+)NCBICelera
Cytogenetic Map1q21NCBI
Prkd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574723,933 - 750,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574723,933 - 750,794 (-)NCBIChiLan1.0ChiLan1.0
PRKD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,195,096 - 52,238,758 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,195,303 - 52,237,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01943,666,591 - 43,710,858 (-)NCBIMhudiblu_PPA_v0panPan3
PRKD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1109,207,067 - 109,330,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11109,206,400 - 109,241,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Prkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936664524,532 - 551,451 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,028,214 - 40,071,523 (-)NCBI
ChlSab1.1 Ensembl640,027,552 - 40,071,455 (-)Ensembl
Prkd2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248326,885,627 - 6,915,316 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 4 1 1
Low 8 2 3 1 2 22 2 2 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000032286   ⟹   ENSSSCP00000020857
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl652,559,393 - 52,599,132 (-)Ensembl
RefSeq Acc Id: XM_021094607   ⟹   XP_020950266
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1652,567,520 - 52,599,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094608   ⟹   XP_020950267
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1652,559,368 - 52,599,143 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002344706
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1652,559,368 - 52,599,174 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002344707
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1652,559,368 - 52,599,142 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002344708
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1652,559,066 - 52,599,144 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020950266 (Get FASTA)   NCBI Sequence Viewer  
  XP_020950267 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020950267   ⟸   XM_021094608
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020950266   ⟸   XM_021094607
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000020857   ⟸   ENSSSCT00000032286
Protein Domains
PH   Phorbol-ester/DAG-type   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026152 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070028184 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000020857 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070048032 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000032286 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070056537 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Protein_Kinase_C_mu-related UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PRKD2 ENTREZGENE
PANTHER PTHR22968 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF PKC_mu_nu_D2 UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A4X1W264_PIG UniProtKB/TrEMBL
  I3L9Z3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91813 ENTREZGENE