TRMT5 (tRNA methyltransferase 5) - Rat Genome Database

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Gene: TRMT5 (tRNA methyltransferase 5) Sus scrofa
Analyze
Symbol: TRMT5
Name: tRNA methyltransferase 5
RGD ID: 14285344
Description: ENCODES a protein that exhibits methyltransferase activity (inferred); tRNA (guanine(37)-N1)-methyltransferase activity (inferred); tRNA methyltransferase activity (inferred); INVOLVED IN methylation (inferred); mitochondrial tRNA methylation (inferred); tRNA methylation (inferred); ASSOCIATED WITH Branchiootic Syndrome 3 (ortholog); combined oxidative phosphorylation deficiency 26 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrion (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tRNA (guanine(37)-N1)-methyltransferase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,909,660 - 189,923,234 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11189,909,654 - 189,923,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,196,389 - 211,205,568 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
mitochondrial matrix  (IBA,IEA)
mitochondrion  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TRMT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,909,660 - 189,923,234 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11189,909,654 - 189,923,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,196,389 - 211,205,568 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRMT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381460,971,441 - 60,981,690 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1460,971,441 - 60,981,170 (-)EnsemblGRCh38hg38GRCh38
GRCh371461,438,159 - 61,448,408 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361460,507,912 - 60,517,535 (-)NCBINCBI36Build 36hg18NCBI36
Celera1441,488,423 - 41,498,046 (-)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1441,601,518 - 41,611,139 (-)NCBIHuRef
CHM1_11461,377,442 - 61,387,063 (-)NCBICHM1_1
T2T-CHM13v2.01455,177,981 - 55,188,230 (-)NCBIT2T-CHM13v2.0
Trmt5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,315,289 - 73,333,754 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,326,785 - 73,333,484 (-)EnsemblGRCm39 Ensembl
GRCm381273,268,515 - 73,286,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,280,011 - 73,286,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv371274,381,397 - 74,387,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361274,198,849 - 74,205,538 (-)NCBIMGSCv36mm8
Celera1274,391,725 - 74,398,044 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.42NCBI
Trmt5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,702,375 - 97,723,534 (-)NCBIGRCr8
mRatBN7.2691,963,558 - 91,987,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,943,724 - 91,987,555 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx692,370,586 - 92,377,255 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,670,084 - 92,676,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,097,974 - 92,104,643 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,164,579 - 96,171,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,153,014 - 96,171,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06105,596,366 - 105,603,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4695,708,552 - 95,715,602 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1695,712,388 - 95,719,101 (-)NCBI
Celera690,443,075 - 90,450,125 (-)NCBICelera
Cytogenetic Map6q24NCBI
Trmt5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,680,429 - 8,685,942 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554668,679,795 - 8,690,203 (+)NCBIChiLan1.0ChiLan1.0
TRMT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21562,108,241 - 62,118,481 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11461,328,331 - 61,334,686 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01441,578,241 - 41,588,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11459,836,893 - 59,847,145 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1459,836,906 - 59,845,936 (-)Ensemblpanpan1.1panPan2
TRMT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1835,952,183 - 35,960,681 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl835,952,365 - 35,960,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha835,705,590 - 35,714,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0836,185,634 - 36,194,515 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl836,183,069 - 36,194,043 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1835,796,181 - 35,805,034 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0835,873,622 - 35,882,503 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0836,235,460 - 36,244,350 (-)NCBIUU_Cfam_GSD_1.0
Trmt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864069,053,660 - 69,063,587 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364955,127,113 - 5,138,343 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364955,131,642 - 5,137,998 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRMT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12438,164,262 - 38,173,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2438,167,915 - 38,174,140 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605326,418,791 - 26,428,466 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trmt5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473440,144,291 - 40,149,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473440,143,073 - 40,154,257 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TRMT5
228 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 3 3 10 1 1
Low 10 3 2 2 13 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000027040   ⟹   ENSSSCP00000020444
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1189,909,660 - 189,923,234 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000058749   ⟹   ENSSSCP00000055032
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1189,909,660 - 189,923,189 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000068709   ⟹   ENSSSCP00000063273
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1189,909,660 - 189,922,718 (-)Ensembl
RefSeq Acc Id: XM_003121846   ⟹   XP_003121894
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11189,909,654 - 189,923,308 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013993474   ⟹   XP_013848928
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11189,909,654 - 189,923,230 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003121894   ⟸   XM_003121846
- Peptide Label: isoform X1
- UniProtKB: A0A8D0MLN8 (UniProtKB/TrEMBL),   I3L8T3 (UniProtKB/TrEMBL),   A0A8D1SP19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848928   ⟸   XM_013993474
- Peptide Label: isoform X2
- UniProtKB: A0A8D1SP19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000055032   ⟸   ENSSSCT00000058749
RefSeq Acc Id: ENSSSCP00000063273   ⟸   ENSSSCT00000068709
RefSeq Acc Id: ENSSSCP00000020444   ⟸   ENSSSCT00000027040
Protein Domains
SAM-dependent methyltransferase TRM5/TYW2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015010386 UniProtKB/TrEMBL
  ENSSSCG00025055168 UniProtKB/TrEMBL
  ENSSSCG00030055435 UniProtKB/TrEMBL
  ENSSSCG00035010945 UniProtKB/TrEMBL
  ENSSSCG00040000269 UniProtKB/TrEMBL
  ENSSSCG00045027186 UniProtKB/TrEMBL
  ENSSSCG00050009600 UniProtKB/TrEMBL
  ENSSSCG00055008827 UniProtKB/TrEMBL
  ENSSSCG00060005121 UniProtKB/TrEMBL
  ENSSSCG00065070441 UniProtKB/TrEMBL
  ENSSSCG00070030514 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000027040 ENTREZGENE
  ENSSSCT00000027040.4 UniProtKB/TrEMBL
  ENSSSCT00000058749 ENTREZGENE
  ENSSSCT00000058749.3 UniProtKB/TrEMBL
  ENSSSCT00000068709.2 UniProtKB/TrEMBL
  ENSSSCT00015013742.1 UniProtKB/TrEMBL
  ENSSSCT00025075538.1 UniProtKB/TrEMBL
  ENSSSCT00030077285.1 UniProtKB/TrEMBL
  ENSSSCT00035013703.1 UniProtKB/TrEMBL
  ENSSSCT00040000333.1 UniProtKB/TrEMBL
  ENSSSCT00045046388.1 UniProtKB/TrEMBL
  ENSSSCT00050012952.1 UniProtKB/TrEMBL
  ENSSSCT00055017276.1 UniProtKB/TrEMBL
  ENSSSCT00060006409.1 UniProtKB/TrEMBL
  ENSSSCT00065096757.1 UniProtKB/TrEMBL
  ENSSSCT00070061426.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
  Met-10+ protein-like domains UniProtKB/TrEMBL
InterPro MeTrfase_TRM5/TYW2 UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
  tRNA_Gua_MeTrfase_euk UniProtKB/TrEMBL
KEGG Report ssc:100519406 UniProtKB/TrEMBL
NCBI Gene TRMT5 ENTREZGENE
PANTHER TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE UniProtKB/TrEMBL
  TRNA METHYLTRANSFERASE UniProtKB/TrEMBL
Pfam Met_10 UniProtKB/TrEMBL
PROSITE SAM_MT_TRM5_TYW2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A287BFX8_PIG UniProtKB/TrEMBL
  A0A4X1W7D9_PIG UniProtKB/TrEMBL
  A0A5G2QG81_PIG UniProtKB/TrEMBL
  A0A8D0MLN8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1SP19 ENTREZGENE, UniProtKB/TrEMBL
  I3L8T3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94451 ENTREZGENE