MYBPC3 (myosin binding protein C3) - Rat Genome Database

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Gene: MYBPC3 (myosin binding protein C3) Sus scrofa
Analyze
Symbol: MYBPC3
Name: myosin binding protein C3
RGD ID: 14283753
Description: ENCODES a protein that exhibits actin binding (inferred); identical protein binding (inferred); myosin binding (inferred); INVOLVED IN cardiac muscle contraction (ortholog); heart morphogenesis (ortholog); myosin filament assembly (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); FOUND IN myofibril (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,247,340 - 15,270,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,454,543 - 16,476,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Animal Disease Models  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
Brugada syndrome  (ISO)
cardiac amyloidosis  (ISO)
cardiac arrest  (ISO)
Cardiac Conduction Defect  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
congenital disorder of glycosylation type IIc  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1I  (ISO)
dilated cardiomyopathy 1MM  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dyspnea  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Hirschsprung's disease  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intellectual disability  (ISO)
Isolated Noncompaction of the Ventricular Myocardium  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 1  (ISO)
long QT syndrome  (ISO)
neuropathy  (ISO)
nuclear type mitochondrial complex I deficiency 20  (ISO)
Paroxysmal Atrial Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
sudden infant death syndrome  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Tachycardia  (ISO)
transthyretin amyloidosis  (ISO)
Ventricular Premature Complexes  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MYBPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,247,340 - 15,270,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,454,543 - 16,476,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYBPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,331,406 - 47,352,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,331,406 - 47,352,702 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,352,957 - 47,374,253 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,309,533 - 47,330,829 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,309,526 - 47,330,798NCBI
Celera1147,492,237 - 47,513,531 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,052,045 - 47,073,383 (-)NCBIHuRef
CHM1_11147,352,197 - 47,373,500 (-)NCBICHM1_1
T2T-CHM13v2.01147,488,226 - 47,509,533 (-)NCBIT2T-CHM13v2.0
Mybpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,948,459 - 90,966,862 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,948,489 - 90,966,861 (+)EnsemblGRCm39 Ensembl
GRCm38291,118,114 - 91,136,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,118,144 - 91,136,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,958,301 - 90,976,673 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,919,009 - 90,937,348 (+)NCBIMGSCv36mm8
Celera292,502,890 - 92,521,291 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Mybpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,550,974 - 97,569,216 (+)NCBIGRCr8
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,573,681 - 80,591,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,172,692 - 89,190,793 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,023,927 - 87,042,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Celera376,303,526 - 76,321,687 (+)NCBICelera
Cytogenetic Map3q24NCBI
Mybpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBIChiLan1.0ChiLan1.0
MYBPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,532,715 - 49,553,783 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,552,509 - 49,573,577 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,277,799 - 47,299,102 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,830,605 - 47,851,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,831,087 - 47,851,849 (-)Ensemblpanpan1.1panPan2
MYBPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,271,159 - 42,288,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,271,724 - 42,289,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,000,886 - 41,017,318 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,926,187 - 42,943,245 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,926,235 - 43,024,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,412,622 - 42,429,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,967,840 - 41,984,282 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,697,140 - 42,713,582 (+)NCBIUU_Cfam_GSD_1.0
Mybpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,759,573 - 19,778,450 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,871,410 - 1,889,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,871,194 - 1,890,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYBPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,964,581 - 17,986,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,963,706 - 17,985,758 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,266,096 - 115,286,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mybpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,406,587 - 1,420,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,406,563 - 1,420,778 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYBPC3
548 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 3 2 3 5 14 1 3
Below cutoff 7 2 8 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014456   ⟹   ENSSSCP00000014064
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,247,340 - 15,269,223 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000039375   ⟹   ENSSSCP00000042773
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,247,340 - 15,269,223 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000074661   ⟹   ENSSSCP00000064197
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,247,340 - 15,269,708 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081757   ⟹   ENSSSCP00000073582
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,247,340 - 15,270,104 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000096763   ⟹   ENSSSCP00000077442
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl215,248,797 - 15,270,104 (+)Ensembl
RefSeq Acc Id: XM_021085215   ⟹   XP_020940874
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085216   ⟹   XP_020940875
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085217   ⟹   XP_020940876
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085218   ⟹   XP_020940877
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085219   ⟹   XP_020940878
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085220   ⟹   XP_020940879
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1215,247,704 - 15,269,714 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020940874   ⟸   XM_021085215
- Peptide Label: isoform X1
- UniProtKB: A0A8D0S2S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940878   ⟸   XM_021085219
- Peptide Label: isoform X5
- UniProtKB: A0A8D0S2S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940875   ⟸   XM_021085216
- Peptide Label: isoform X2
- UniProtKB: A0A8D0S2S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940876   ⟸   XM_021085217
- Peptide Label: isoform X3
- UniProtKB: A0A8D0S2S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940877   ⟸   XM_021085218
- Peptide Label: isoform X4
- UniProtKB: A0A8D0S2S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940879   ⟸   XM_021085220
- Peptide Label: isoform X6
- UniProtKB: A0A8D1KMT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000042773   ⟸   ENSSSCT00000039375
RefSeq Acc Id: ENSSSCP00000064197   ⟸   ENSSSCT00000074661
RefSeq Acc Id: ENSSSCP00000073582   ⟸   ENSSSCT00000081757
RefSeq Acc Id: ENSSSCP00000014064   ⟸   ENSSSCT00000014456
RefSeq Acc Id: ENSSSCP00000077442   ⟸   ENSSSCT00000096763
Protein Domains
Fibronectin type-III   Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013236 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025038394 UniProtKB/TrEMBL
  ENSSSCG00040075996 UniProtKB/TrEMBL
  ENSSSCG00045038769 UniProtKB/TrEMBL
  ENSSSCG00055024002 UniProtKB/TrEMBL
  ENSSSCG00065045095 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014456 ENTREZGENE
  ENSSSCT00000014456.5 UniProtKB/TrEMBL
  ENSSSCT00000039375.3 UniProtKB/TrEMBL
  ENSSSCT00000074661 ENTREZGENE
  ENSSSCT00000074661.2 UniProtKB/TrEMBL
  ENSSSCT00000081757.2 UniProtKB/TrEMBL
  ENSSSCT00000096763.1 UniProtKB/TrEMBL
  ENSSSCT00025053349.1 UniProtKB/TrEMBL
  ENSSSCT00040105735.1 UniProtKB/TrEMBL
  ENSSSCT00045067732.1 UniProtKB/TrEMBL
  ENSSSCT00055049745.1 UniProtKB/TrEMBL
  ENSSSCT00065061980.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  MyBP-C_THB UniProtKB/TrEMBL
NCBI Gene MYBPC3 ENTREZGENE
PANTHER MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE UniProtKB/TrEMBL
  TITIN UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  THB UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniProt A0A287AFL5_PIG UniProtKB/TrEMBL
  A0A5G2QJR5_PIG UniProtKB/TrEMBL
  A0A5G2RFI9_PIG UniProtKB/TrEMBL
  A0A8D0S2S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KMT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FF03_PIG UniProtKB/TrEMBL
  F1SID7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90501 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-08 MYBPC3  myosin binding protein C3  MYBPC3  myosin binding protein C, cardiac  Symbol and/or name change 5135510 APPROVED