DPPA3 (developmental pluripotency associated 3)

Gene: DPPA3 (developmental pluripotency associated 3) Sus scrofa

Analyze

Symbol:

DPPA3

Name:

developmental pluripotency associated 3

RGD ID:

14271203

Description:

ENCODES a protein that exhibits methylated histone binding (inferred); INVOLVED IN embryonic cleavage (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 21 (ortholog); genetic disease (ortholog); Germ Cell and Embryonal Neoplasms (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); female pronucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

developmental pluripotency-associated protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	62,861,492 - 62,868,131 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	65,691,481 - 65,702,154 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 21 (ISO)

genetic disease (ISO)

Germ Cell and Embryonal Neoplasms (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

Klippel-Feil syndrome 3 (ISO)

lymphoproliferative syndrome 2 (ISO)

peroxisome biogenesis disorder 2B (ISO)

Temtamy syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

embryonic cleavage (ISO)

epigenetic programing of female pronucleus (IEA)

negative regulation of DNA demethylation (IEA)

Cellular Component

chromatin (ISO)

cytoplasm (ISO)

female pronucleus (ISO)

male pronucleus (ISO)

nucleus (IEA)

Molecular Function

methylated histone binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:27566850	PMID:30032202

Genomics

Comparative Map Data

DPPA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	62,861,492 - 62,868,131 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	65,691,481 - 65,702,154 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DPPA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	7,711,433 - 7,717,559 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	7,711,433 - 7,717,559 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	7,864,029 - 7,870,155 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	7,755,356 - 7,761,422 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	7,755,355 - 7,761,417	NCBI
Celera	12	9,442,212 - 9,448,285 (+)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	7,678,041 - 7,684,114 (+)	NCBI		HuRef
CHM1_1	12	7,862,915 - 7,869,510 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	7,726,072 - 7,732,205 (+)	NCBI		T2T-CHM13v2.0

Dppa3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	122,603,383 - 122,607,230 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	122,603,369 - 122,607,231 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	122,626,424 - 122,630,271 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	122,626,410 - 122,630,272 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	122,576,442 - 122,580,289 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	122,592,043 - 122,595,890 (+)	NCBI		MGSCv36	mm8
Celera	6	124,426,164 - 124,430,002 (+)	NCBI		Celera
Cytogenetic Map	6	F1	NCBI
cM Map	6	57.72	NCBI

Dppa3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,523,426 - 157,526,810 (+)	NCBI		GRCr8
mRatBN7.2	4	155,851,461 - 155,854,845 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	155,815,296 - 155,854,861 (+)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	5	88,097,665 - 88,098,141 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	162,115,960 - 162,119,338 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	157,899,173 - 157,902,551 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,544,266 - 156,547,644 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,437,675 - 155,441,059 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	222,459,195 - 222,464,881 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	159,083,360 - 159,086,744 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	159,328,295 - 159,331,696 (+)	NCBI
Celera	4	144,670,614 - 144,673,998 (+)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

DPPA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	13,269,015 - 13,275,786 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	13,265,774 - 13,272,545 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,834,298 - 7,841,064 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	7,994,606 - 8,000,731 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

DPPA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	37,114,192 - 37,196,434 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	9,417,788 - 9,502,171 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	37,463,510 - 37,549,060 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	27	37,344,581 - 37,429,586 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	37,379,470 - 37,464,429 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	8,902,815 - 8,988,437 (-)	NCBI		UU_Cfam_GSD_1.0

DPPA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	7,743,045 - 7,751,285 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666063	450,101 - 455,796 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dppa3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624860	4,974,941 - 4,978,295 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in DPPA3
267 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021093127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU929253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_021093127 ⟹ XP_020948786

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	5	62,861,492 - 62,868,131 (-)	NCBI

Sequence:

show sequence

TTTGTTTGTGGGAGGCAATGGGACCTTGACTCTTAGGTTGGGTTTGTCTTCCCCTTTCTGGTCG
ATACAGTTCTTCAAGGCTACTTTTGTAGCAATTTGAGAATCTAAAGGATCAGCTTCCAGTGGAA
CCCAAAGAGGAAGGAGCTCCTGGCTGTGGCTAGACTCCCAATGGATTCATCGGATGTTAATCCA
ACCCGGACTCAGGATTCTCAAATGTTCGTTGAGGAAAATTCCCAGGAAACGCCGGCTGCTTCTC
AACCTGTCTATGATGTGTTAATACAGAACCTCAGTAACTTGACTCTCAACCCAAGGACAAAATT
TCTATCCATAAAATCAGAAAATCGACCTCAACCGACTATCCGGAGGCTTGGTGAAGGCATCCCA
CCTCAACCAACTGGCCGGAGACTTGGTGAAGGCATCATTCCTAGGAGGAAAGGGGTGAGGACGT
TGTTAAGTGTTCGGAGAGAAAGGATGGAATGGATGATTCGGTATTTCAAAAACCGCTATGGCAA
AACTCAGACAAAATCAGGAGAGCAGCGATTTCGGTGCACCTGTACTTATTGCCTGTATAATAGA
GATCCTGCTGAGGATAATTATGAAAATAATTACGACAGTAATTAGGATGACGGTGATGACAGTA
ATTCCAAGGCTGAGTAGGTTGAGCCCACAACCTCGTTCTTGTACTATTTTTTTCTCACTTGTAA
TTGTAGAATGATCATGAAGCAACTTAGGAAAGATTGTGTACCAATATTTAGATAACCTAGTAAG
TTCTGTGATACCTTTTTTCCTGCATCTCTTTTTCTACCTCCTTAATACAGGTTACTATGAGGAA
TCTATGTAGGATGCATTTGAATGACTTGACTGTACTTTAGTCCCACTTTGATTTGACACAAAGA
AGCACTATTTCGTCTCAGGTTTTGCCTCTTTTGGCAGCCCCAAGTCTAGAAGATGAAACCCAGT
ATCAAGAATGTGAAGCAAATTAATTTGTGTGGAAGGAATCTAAAGAAAATGTTGGGTAGTTTGG
CTAGAACATTATTAGAGCAGCTATTGCATTGTTAGAAAAAATGTTGATATACTGTTCTAATTTT
CAGTAGCAAATATATTGTATATAGAGGATGATCTTATTAAAACCTGAGAGATTTGAGTATCTTT
AAATAAAATTATTGTTCTTATTTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020948786	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00070021420.1

RefSeq Acc Id:	XP_020948786 ⟸ XM_021093127
- UniProtKB:	A0A4X1U0W6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDSSDVNPTRTQDSQMFVEENSQETPAASQPVYDVLIQNLSNLTLNPRTKFLSIKSENRPQPTI RRLGEGIPPQPTGRRLGEGIIPRRKGVRTLLSVRRERMEWMIRYFKNRYGKTQTKSGEQRFRCT CTYCLYNRDPAEDNYENNYDSN hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00070013216	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00070025813.1	UniProtKB/TrEMBL
InterPro	Dppa3	UniProtKB/TrEMBL
NCBI Gene	DPPA3	ENTREZGENE
PANTHER	DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 3	UniProtKB/TrEMBL
	DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 3-RELATED	UniProtKB/TrEMBL
Pfam	PGC7_Stella	UniProtKB/TrEMBL
UniProt	A0A4X1U0W6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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