F7 (coagulation factor VII) - Rat Genome Database

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Gene: F7 (coagulation factor VII) Sus scrofa
Analyze
Symbol: F7
Name: coagulation factor VII
RGD ID: 14268312
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); serine-type endopeptidase activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); blood coagulation (ortholog); circadian rhythm (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acquired angioedema (ortholog); Acute Liver Failure (ortholog); acute pancreatitis (ortholog); FOUND IN extracellular space (ortholog); membrane (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coagulation factor VII (serum prothrombin conversion accelerator)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,512,137 - 78,518,668 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,512,389 - 78,518,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,217,112 - 86,223,394 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired angioedema  (ISO)
Acute Liver Failure  (ISO)
acute pancreatitis  (ISO)
Albuminuria  (ISO)
Angina, Stable  (ISO)
Animal Disease Models  (ISO)
Arterial Thrombosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
bilirubin metabolic disorder  (ISO)
blood coagulation disease  (ISO)
breast cancer  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Allograft Dysfunction  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
coronary artery disease  (ISO)
diabetes mellitus  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (ISO)
Endotoxemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Extrahepatic Portal Vein Obstruction  (ISO)
factor VII deficiency  (ISO)
factor X deficiency  (ISO)
familial hyperlipidemia  (ISO)
Glandular and Epithelial Neoplasms  (ISO)
Hematuria  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
hereditary angioedema  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypothyroidism  (ISO)
Inherited Blood Coagulation Disease  (ISO)
Insulin Resistance  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
Intracranial Hemorrhage, Traumatic  (ISO)
Intracranial Hemorrhages  (ISO)
kidney disease  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
Postoperative Complications  (ISO)
proteinuria  (ISO)
prothrombin deficiency  (ISO)
Sepsis  (ISO)
Smoke Inhalation Injury  (ISO)
Subdural Hematoma, Acute  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:19286401  


Genomics

Comparative Map Data
F7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,512,137 - 78,518,668 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,512,389 - 78,518,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,217,112 - 86,223,394 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,105,788 - 113,120,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13113,105,788 - 113,120,685 (+)EnsemblGRCh38hg38GRCh38
GRCh3713113,760,102 - 113,774,999 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,808,106 - 112,822,996 (+)NCBINCBI36hg18NCBI36
Build 3413112,808,105 - 112,822,346NCBI
Celera1394,585,687 - 94,600,980 (+)NCBI
Cytogenetic Map13q34NCBI
HuRef1394,198,534 - 94,213,700 (+)NCBIHuRef
CHM1_113113,728,824 - 113,743,117 (+)NCBICHM1_1
T2T-CHM13v2.013112,357,141 - 112,372,343 (+)NCBI
F7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,075,499 - 13,085,809 (+)NCBIGRCm39mm39
GRCm39 Ensembl813,076,034 - 13,085,809 (+)Ensembl
GRCm38813,025,506 - 13,035,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,026,034 - 13,035,809 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,026,034 - 13,035,809 (+)NCBIGRCm37mm9NCBIm37
MGSCv36813,026,023 - 13,035,786 (+)NCBImm8
Celera813,193,833 - 13,203,593 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
F7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21676,489,779 - 76,500,636 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1676,489,717 - 76,500,610 (-)Ensembl
Rnor_6.01681,824,610 - 81,834,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,824,111 - 81,834,945 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,309,476 - 81,320,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,348,678 - 81,358,991 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11681,348,942 - 81,359,256 (-)NCBI
Celera1674,296,307 - 74,306,282 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
F7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404680,594 - 693,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955404685,170 - 692,797 (-)NCBIChiLan1.0ChiLan1.0
F7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113113,315,868 - 113,329,995 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,315,868 - 113,329,995 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01394,246,694 - 94,261,133 (+)NCBIMhudiblu_PPA_v0panPan3
F7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,572,459 - 60,582,743 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,571,822 - 60,597,024 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,285,105 - 60,295,147 (+)NCBI
ROS_Cfam_1.02261,197,920 - 61,208,435 (+)NCBI
ROS_Cfam_1.0 Ensembl2261,197,839 - 61,208,421 (+)Ensembl
UMICH_Zoey_3.12260,696,588 - 60,706,712 (+)NCBI
UNSW_CanFamBas_1.02260,698,754 - 60,708,987 (+)NCBI
UU_Cfam_GSD_1.02260,729,611 - 60,740,074 (+)NCBI
F7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,436,780 - 195,446,532 (+)NCBI
SpeTri2.0NW_004936472505,751 - 515,375 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,109,864 - 91,122,707 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl391,110,380 - 91,123,327 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604648,125,875 - 48,139,708 (+)NCBIVero_WHO_p1.0
F7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793780,059 - 788,095 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624793780,057 - 788,105 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system nervous system
High
Medium
Low 1
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010478   ⟹   ENSSSCP00000010206
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1178,512,137 - 78,518,668 (+)Ensembl
RefSeq Acc Id: NM_001044591   ⟹   NP_001038056
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11178,512,389 - 78,518,668 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001038056 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABF82360 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001038056   ⟸   NM_001044591
- Peptide Label: precursor
- UniProtKB: Q19AZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010206   ⟸   ENSSSCT00000010478
Protein Domains
EGF-like   Gla   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029503 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010206 ENTREZGENE
  ENSSSCP00000010206.4 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010478 ENTREZGENE
  ENSSSCT00000010478.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  IPR033190 UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report ssc:733661 UniProtKB/TrEMBL
NCBI Gene F7 ENTREZGENE
PANTHER PTHR24278:SF26 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF Factor_X UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
  GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF57630 UniProtKB/TrEMBL
UniProt F1RN40_PIG UniProtKB/TrEMBL
  Q19AZ7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87866 ENTREZGENE