SOSTDC1 (sclerostin domain containing 1) - Rat Genome Database
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Gene: SOSTDC1 (sclerostin domain containing 1) Sus scrofa
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Symbol: SOSTDC1
Name: sclerostin domain containing 1
RGD ID: 14266242
Description: ENCODES a protein that exhibits BMP binding (inferred); BMP receptor activity (inferred); INVOLVED IN hair follicle morphogenesis (ortholog); mammary gland bud morphogenesis (ortholog); negative regulation of BMP signaling pathway (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH congenital muscular dystrophy-dystroglycanopathy A7 (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sclerostin domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl985,743,335 - 85,747,591 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1985,743,332 - 85,747,893 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2994,581,754 - 94,585,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SOSTDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl985,743,335 - 85,747,591 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1985,743,332 - 85,747,893 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2994,581,754 - 94,585,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOSTDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl716,461,481 - 16,530,580 (-)EnsemblGRCh38hg38GRCh38
GRCh38716,461,481 - 16,465,738 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37716,501,106 - 16,505,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36716,467,631 - 16,471,999 (-)NCBINCBI36hg18NCBI36
Build 34716,274,347 - 16,278,714NCBI
Celera716,480,854 - 16,485,222 (-)NCBI
Cytogenetic Map7p21.2NCBI
HuRef716,387,637 - 16,392,005 (-)NCBIHuRef
CHM1_1716,500,852 - 16,505,220 (-)NCBICHM1_1
CRA_TCAGchr7v2716,554,239 - 16,558,607 (-)NCBI
Sostdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391236,364,168 - 36,368,451 (+)NCBIGRCm39mm39
GRCm39 Ensembl1236,364,138 - 36,368,451 (+)Ensembl
GRCm381236,314,169 - 36,318,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1236,314,139 - 36,318,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv371237,040,756 - 37,045,039 (+)NCBIGRCm37mm9NCBIm37
MGSCv361236,824,492 - 36,828,711 (+)NCBImm8
Celera1237,763,054 - 37,767,254 (+)NCBICelera
Cytogenetic Map12A3NCBI
Sostdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2653,051,336 - 53,055,510 (+)NCBI
Rnor_6.0 Ensembl655,812,747 - 55,817,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0655,812,820 - 55,816,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0665,423,740 - 65,427,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4655,066,277 - 55,070,451 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1655,069,402 - 55,073,577 (+)NCBI
Celera652,193,795 - 52,197,969 (+)NCBICelera
Cytogenetic Map6q16NCBI
Sostdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541019,657,029 - 19,662,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541019,657,805 - 19,662,121 (-)NCBIChiLan1.0ChiLan1.0
SOSTDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1716,443,703 - 16,448,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl716,443,703 - 16,448,076 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0717,116,828 - 17,121,142 (-)NCBIMhudiblu_PPA_v0panPan3
SOSTDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1431,022,766 - 31,026,737 (-)NCBICanFam3.1canFam3CanFam3.1
CanFam3.11431,035,759 - 31,079,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sostdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365462,976,045 - 2,980,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOSTDC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12141,645,884 - 41,651,360 (+)NCBI
ChlSab1.1 Ensembl2141,647,079 - 41,652,093 (+)Ensembl
Sostdc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473913,767,523 - 13,771,708 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 5 3 2 18 1 2 1
Below cutoff 3 2 1 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025071   ⟹   ENSSSCP00000024419
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl985,743,335 - 85,747,591 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000081356   ⟹   ENSSSCP00000066950
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl985,744,293 - 85,747,461 (-)Ensembl
RefSeq Acc Id: XM_003482678   ⟹   XP_003482726
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1985,743,332 - 85,747,893 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003482726 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003482726   ⟸   XM_003482678
- UniProtKB: F1SEJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000024419   ⟸   ENSSSCT00000025071
RefSeq Acc Id: ENSSSCP00000066950   ⟸   ENSSSCT00000081356
Protein Domains
CTCK


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021126 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070009098 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024419 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000066950 UniProtKB/TrEMBL
  ENSSSCP00070014632 UniProtKB/TrEMBL
  ENSSSCP00070014641 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025071 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000081356 UniProtKB/TrEMBL
  ENSSSCT00070017646 UniProtKB/TrEMBL
  ENSSSCT00070017655 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Sclerostin/SOSTDC1 UniProtKB/TrEMBL
KEGG Report ssc:100736999 UniProtKB/TrEMBL
NCBI Gene SOSTDC1 ENTREZGENE
PANTHER PTHR14903 UniProtKB/TrEMBL
Pfam Sclerostin UniProtKB/TrEMBL
PROSITE CTCK_2 UniProtKB/TrEMBL
UniProt A0A4X1THK2_PIG UniProtKB/TrEMBL
  A0A4X1TIA5_PIG UniProtKB/TrEMBL
  A0A5G2QPX7_PIG UniProtKB/TrEMBL
  F1SEJ1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93346 ENTREZGENE