KLHL21 (kelch like family member 21) - Rat Genome Database

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Gene: KLHL21 (kelch like family member 21) Sus scrofa
Analyze
Symbol: KLHL21
Name: kelch like family member 21
RGD ID: 14255639
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN cell division (inferred); chromosome passenger complex localization to spindle midzone (inferred); protein ubiquitination (inferred); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); genetic disease (ortholog); high grade glioma (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 21; kelch-like protein 21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,420,622 - 67,434,812 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,420,618 - 67,434,812 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,395,591 - 62,405,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
KLHL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,420,622 - 67,434,812 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,420,618 - 67,434,812 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,395,591 - 62,405,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,590,724 - 6,602,869 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,590,724 - 6,614,607 (-)EnsemblGRCh38hg38GRCh38
GRCh3716,650,784 - 6,662,929 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,573,371 - 6,585,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 3416,585,050 - 6,597,195NCBI
Celera15,764,642 - 5,776,787 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,798,711 - 5,810,856 (-)NCBIHuRef
CHM1_116,639,510 - 6,651,654 (-)NCBICHM1_1
T2T-CHM13v2.016,116,388 - 6,128,533 (-)NCBIT2T-CHM13v2.0
Klhl21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,093,348 - 152,102,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,093,260 - 152,102,137 (+)EnsemblGRCm39 Ensembl
GRCm384152,008,891 - 152,017,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,008,803 - 152,017,680 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,383,000 - 151,391,786 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364150,852,691 - 150,861,477 (+)NCBIMGSCv36mm8
Celera4154,295,035 - 154,303,821 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map482.82NCBI
Klhl21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,797,621 - 167,806,276 (+)NCBIGRCr8
mRatBN7.25162,514,888 - 162,523,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,514,765 - 162,523,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,217,955 - 165,226,725 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,038,924 - 167,047,582 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,001,124 - 167,009,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,181,418 - 169,190,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,181,418 - 169,190,073 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,740,028 - 172,748,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,236,427 - 169,246,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,246,580 - 169,254,165 (+)NCBI
Celera5160,747,612 - 160,756,322 (+)NCBICelera
Cytogenetic Map5q36NCBI
Klhl21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554866,038,291 - 6,047,814 (+)NCBIChiLan1.0ChiLan1.0
KLHL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,625,159 - 221,637,412 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,267,327 - 220,279,514 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015,352,020 - 5,364,268 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,604,801 - 6,616,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,604,801 - 6,616,890 (-)Ensemblpanpan1.1panPan2
KLHL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,415,493 - 60,427,301 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,413,552 - 60,427,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,425,033 - 60,436,809 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,631,172 - 60,643,210 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,631,250 - 60,643,259 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,630,243 - 60,642,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,496,924 - 60,508,708 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,900,730 - 60,911,153 (-)NCBIUU_Cfam_GSD_1.0
Klhl21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,859,365 - 30,870,408 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366231,344,622 - 1,355,739 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366231,344,603 - 1,355,594 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,142,580 - 125,156,153 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,143,114 - 125,157,484 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,187,672 - 29,201,242 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248184,931,296 - 4,942,199 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248184,931,288 - 4,941,363 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLHL21
333 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 8 4 3 5 1 22 2 3 3
Below cutoff 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003750   ⟹   ENSSSCP00000003664
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl667,420,622 - 67,434,812 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090414   ⟹   ENSSSCP00000062101
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl667,423,522 - 67,434,812 (-)Ensembl
RefSeq Acc Id: XM_005656009   ⟹   XP_005656066
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1667,420,618 - 67,434,812 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005656066   ⟸   XM_005656009
- UniProtKB: A0A4X1W806 (UniProtKB/TrEMBL),   M3VK42 (UniProtKB/TrEMBL),   F1RIK0 (UniProtKB/TrEMBL),   A0A5G2QD90 (UniProtKB/TrEMBL),   A0A8D1ZSF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000062101   ⟸   ENSSSCT00000090414
RefSeq Acc Id: ENSSSCP00000003664   ⟸   ENSSSCT00000003750
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003379 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025076439 UniProtKB/TrEMBL
  ENSSSCG00030071418 UniProtKB/TrEMBL
  ENSSSCG00035001066 UniProtKB/TrEMBL
  ENSSSCG00040039940 UniProtKB/TrEMBL
  ENSSSCG00045039279 UniProtKB/TrEMBL
  ENSSSCG00050066765 UniProtKB/TrEMBL
  ENSSSCG00055004377 UniProtKB/TrEMBL
  ENSSSCG00060039704 UniProtKB/TrEMBL
  ENSSSCG00065064182 UniProtKB/TrEMBL
  ENSSSCG00070029552 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003750 ENTREZGENE
  ENSSSCT00000003750.5 UniProtKB/TrEMBL
  ENSSSCT00000090414.2 UniProtKB/TrEMBL
  ENSSSCT00025105861.1 UniProtKB/TrEMBL
  ENSSSCT00030099999.1 UniProtKB/TrEMBL
  ENSSSCT00035001291.1 UniProtKB/TrEMBL
  ENSSSCT00040053491.1 UniProtKB/TrEMBL
  ENSSSCT00040053534.1 UniProtKB/TrEMBL
  ENSSSCT00045068371.1 UniProtKB/TrEMBL
  ENSSSCT00050090953.1 UniProtKB/TrEMBL
  ENSSSCT00055008639.1 UniProtKB/TrEMBL
  ENSSSCT00060053736.1 UniProtKB/TrEMBL
  ENSSSCT00065088106.1 UniProtKB/TrEMBL
  ENSSSCT00065088114.1 UniProtKB/TrEMBL
  ENSSSCT00070059395.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL21 UniProtKB/TrEMBL
  KLHL21_BACK UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
KEGG Report ssc:106504088 UniProtKB/TrEMBL
NCBI Gene KLHL21 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  PTHR24412:SF255 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  Kelch_6 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A480RGQ1_PIG UniProtKB/TrEMBL
  A0A4X1W806 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QD90 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ZSF6 ENTREZGENE, UniProtKB/TrEMBL
  F1RIK0 ENTREZGENE, UniProtKB/TrEMBL
  M3VK42 ENTREZGENE
UniProt Secondary M3VK42 UniProtKB/TrEMBL
VGNC ID VGNC:89520 ENTREZGENE