PRKACA (protein kinase cAMP-activated catalytic subunit alpha) - Rat Genome Database

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Gene: PRKACA (protein kinase cAMP-activated catalytic subunit alpha) Sus scrofa
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Symbol: PRKACA
Name: protein kinase cAMP-activated catalytic subunit alpha
RGD ID: 14255237
Description: ENCODES a protein that exhibits cAMP-dependent protein kinase activity; protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of meiotic cell cycle process involved in oocyte maturation; cellular response to heat (ortholog); cellular response to parathyroid hormone stimulus (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH adrenal cortical adenoma (ortholog); Adrenal Gland Neoplasms (ortholog); brain ischemia (ortholog); FOUND IN cytoplasm; germinal vesicle; acrosomal vesicle (ortholog); INTERACTS WITH copper atom; copper(0); sodium arsenite
Type: protein-coding
RefSeq Status: MODEL
Also known as: C-alpha subunit; cAMP-dependent protein kinase catalytic subunit alpha; PKA; protein kinase A; protein kinase, cAMP-dependent, catalytic, alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,074,870 - 65,095,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,074,876 - 65,095,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,350,544 - 65,371,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
dopamine signaling pathway  (ISO)
eicosanoid signaling pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
protein kinase A (PKA) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:2441988   PMID:8443157   PMID:9521123   PMID:10684253   PMID:16155364   PMID:16284184   PMID:17594292   PMID:19911376   PMID:20388485   PMID:22674394   PMID:25178840  


Genomics

Comparative Map Data
PRKACA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,074,870 - 65,095,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,074,876 - 65,095,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,350,544 - 65,371,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,091,688 - 14,118,084 (-)EnsemblGRCh38hg38GRCh38
GRCh381914,091,688 - 14,117,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,202,500 - 14,228,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,063,500 - 14,089,559 (-)NCBINCBI36hg18NCBI36
Build 341914,063,508 - 14,085,992NCBI
Celera1914,096,777 - 14,122,833 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,774,379 - 13,800,126 (-)NCBIHuRef
CHM1_11914,202,926 - 14,228,985 (-)NCBICHM1_1
Prkaca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,699,607 - 84,723,073 (+)NCBIGRCm39mm39
GRCm39 Ensembl884,699,622 - 84,723,072 (+)Ensembl
GRCm38883,972,978 - 83,996,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,972,993 - 83,996,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,496,877 - 86,520,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv36886,863,093 - 86,886,544 (+)NCBImm8
Celera888,266,474 - 88,289,645 (+)NCBICelera
Cytogenetic Map8C2NCBI
Prkaca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,155,081 - 24,178,430 (-)NCBI
Rnor_6.0 Ensembl1925,095,089 - 25,118,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01925,095,089 - 25,118,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01936,073,104 - 36,096,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,840,795 - 25,864,786 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,845,620 - 25,861,927 (-)NCBI
Celera1923,703,180 - 23,726,723 (-)NCBICelera
Cytogenetic Map19q11NCBI
Prkaca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,793,718 - 32,812,930 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,794,172 - 32,807,944 (-)NCBIChiLan1.0ChiLan1.0
PRKACA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,385,183 - 14,406,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,385,191 - 14,406,205 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01913,657,344 - 13,683,864 (-)NCBIMhudiblu_PPA_v0panPan3
PRKACA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,416,730 - 48,425,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,409,045 - 48,426,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,283,546 - 48,299,768 (+)NCBI
ROS_Cfam_1.02048,926,811 - 48,944,065 (+)NCBI
UMICH_Zoey_3.12048,138,017 - 48,154,228 (+)NCBI
UNSW_CanFamBas_1.02048,564,570 - 48,580,793 (+)NCBI
UU_Cfam_GSD_1.02048,807,387 - 48,823,603 (+)NCBI
Prkaca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,588,938 - 207,605,559 (+)NCBI
SpeTri2.0NW_0049366592,750,015 - 2,765,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,743,752 - 12,759,155 (-)NCBI
Vero_WHO_p1.0NW_0236660746,888,080 - 6,914,845 (+)NCBI
Prkaca
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,319,426 - 1,336,848 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 3 1 2 23 1
Low 7 2 4 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015046   ⟹   ENSSSCP00000014641
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl265,074,870 - 65,095,553 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044305   ⟹   ENSSSCP00000035101
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl265,083,485 - 65,095,553 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064451   ⟹   ENSSSCP00000041472
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl265,078,790 - 65,095,553 (+)Ensembl
RefSeq Acc Id: XM_003123353   ⟹   XP_003123401
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1265,074,876 - 65,095,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003354103   ⟹   XP_003354151
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1265,078,775 - 65,095,564 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003123401 (Get FASTA)   NCBI Sequence Viewer  
  XP_003354151 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACE79215 (Get FASTA)   NCBI Sequence Viewer  
  CAA30470 (Get FASTA)   NCBI Sequence Viewer  
  P36887 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003123401   ⟸   XM_003123353
- Peptide Label: isoform X1
- UniProtKB: F1SD45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003354151   ⟸   XM_003354103
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000014641   ⟸   ENSSSCT00000015046
RefSeq Acc Id: ENSSSCP00000041472   ⟸   ENSSSCT00000064451
RefSeq Acc Id: ENSSSCP00000035101   ⟸   ENSSSCT00000044305

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013771 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022524 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014641 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000035101 UniProtKB/TrEMBL
  ENSSSCP00000041472 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070037744 UniProtKB/TrEMBL
  ENSSSCP00070037751 UniProtKB/TrEMBL
  ENSSSCP00070037753 UniProtKB/TrEMBL
  ENSSSCP00070037755 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015046 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000044305 UniProtKB/TrEMBL
  ENSSSCT00000064451 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070044788 UniProtKB/TrEMBL
  ENSSSCT00070044798 UniProtKB/TrEMBL
  ENSSSCT00070044800 UniProtKB/TrEMBL
  ENSSSCT00070044803 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_PKA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397652 UniProtKB/TrEMBL
NCBI Gene PRKACA ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZUD6_PIG UniProtKB/TrEMBL
  A0A287ACC3_PIG UniProtKB/TrEMBL
  A0A4X1V8A4_PIG UniProtKB/TrEMBL
  A0A4X1V926_PIG UniProtKB/TrEMBL
  A0A4X1VAB5_PIG UniProtKB/TrEMBL
  A0A4X1VAC1_PIG UniProtKB/TrEMBL
  F1SD45 ENTREZGENE, UniProtKB/TrEMBL
  KAPCA_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:100332 ENTREZGENE