SIGLEC15 (sialic acid binding Ig like lectin 15) - Rat Genome Database

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Gene: SIGLEC15 (sialic acid binding Ig like lectin 15) Sus scrofa
Analyze
Symbol: SIGLEC15
Name: sialic acid binding Ig like lectin 15
RGD ID: 14254587
Description: INVOLVED IN regulation of actin cytoskeleton organization (ortholog); regulation of bone resorption (ortholog); regulation of osteoclast development (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Microcephaly, Epilepsy, and Diabetes Syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); protein-containing complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sialic acid-binding Ig-like lectin 15
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,475,438 - 95,492,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1195,475,108 - 95,492,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21105,534,846 - 105,551,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SIGLEC15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,475,438 - 95,492,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1195,475,108 - 95,492,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21105,534,846 - 105,551,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIGLEC15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381845,825,675 - 45,844,094 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1845,825,675 - 45,844,094 (+)EnsemblGRCh38hg38GRCh38
GRCh371843,405,640 - 43,424,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361841,659,543 - 41,676,519 (+)NCBINCBI36Build 36hg18NCBI36
Celera1840,213,693 - 40,230,671 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
HuRef1840,262,525 - 40,279,514 (+)NCBIHuRef
CHM1_11843,332,814 - 43,349,827 (+)NCBICHM1_1
T2T-CHM13v2.01846,016,614 - 46,035,042 (+)NCBIT2T-CHM13v2.0
Siglec15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391878,085,708 - 78,100,656 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1878,086,829 - 78,100,610 (-)EnsemblGRCm39 Ensembl
GRCm381878,042,493 - 78,057,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1878,043,614 - 78,057,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371878,240,353 - 78,254,007 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361878,209,258 - 78,219,471 (-)NCBIMGSCv36mm8
Celera1879,184,382 - 79,198,324 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1852.43NCBI
Siglec15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,781,536 - 73,797,014 (-)NCBIGRCr8
mRatBN7.21871,506,416 - 71,521,894 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,505,399 - 71,521,881 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,607,204 - 73,621,153 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01874,276,484 - 74,290,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01872,133,055 - 72,147,004 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01874,403,384 - 74,417,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,403,384 - 74,417,333 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01874,076,491 - 74,082,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,950,664 - 74,964,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1870,026,475 - 70,040,424 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
Siglec15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540231,403,965 - 31,417,386 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540231,403,765 - 31,418,954 (+)NCBIChiLan1.0ChiLan1.0
SIGLEC15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21763,250,286 - 63,272,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11848,953,073 - 48,965,221 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01839,111,697 - 39,125,631 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11842,650,679 - 42,663,810 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1842,658,534 - 42,663,773 (+)Ensemblpanpan1.1panPan2
SIGLEC15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1745,322,677 - 45,338,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl745,324,440 - 45,337,814 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha744,805,282 - 44,818,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0745,276,581 - 45,290,006 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl745,276,954 - 45,289,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1744,975,670 - 44,989,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0745,032,622 - 45,043,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0745,313,669 - 45,327,587 (-)NCBIUU_Cfam_GSD_1.0
Siglec15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494441,617,901 - 41,633,243 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936517946,341 - 953,674 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936517945,345 - 960,591 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIGLEC15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11835,070,459 - 35,087,525 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660509,441,500 - 9,459,901 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Siglec15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247789,472,529 - 9,487,973 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SIGLEC15
426 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low 3 2 3 3 5 1 1
Below cutoff 6 2 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004964   ⟹   ENSSSCP00000004847
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl195,475,447 - 95,492,709 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069294   ⟹   ENSSSCP00000066130
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl195,483,834 - 95,492,708 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000073855   ⟹   ENSSSCP00000060061
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl195,475,438 - 95,492,709 (+)Ensembl
RefSeq Acc Id: XM_003121417   ⟹   XP_003121465
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1195,475,108 - 95,492,675 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003121465   ⟸   XM_003121417
- UniProtKB: A0A5G2Q878 (UniProtKB/TrEMBL),   A0A8D1DRX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000060061   ⟸   ENSSSCT00000073855
RefSeq Acc Id: ENSSSCP00000066130   ⟸   ENSSSCT00000069294
RefSeq Acc Id: ENSSSCP00000004847   ⟸   ENSSSCT00000004964
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025051365 UniProtKB/TrEMBL
  ENSSSCG00030004513 UniProtKB/TrEMBL
  ENSSSCG00035033461 UniProtKB/TrEMBL
  ENSSSCG00040018226 UniProtKB/TrEMBL
  ENSSSCG00045024219 UniProtKB/TrEMBL
  ENSSSCG00050017494 UniProtKB/TrEMBL
  ENSSSCG00055018364 UniProtKB/TrEMBL
  ENSSSCG00060040400 UniProtKB/TrEMBL
  ENSSSCG00065020459 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004964.3 UniProtKB/TrEMBL
  ENSSSCT00000073855 ENTREZGENE
  ENSSSCT00000073855.2 UniProtKB/TrEMBL
  ENSSSCT00025070199.1 UniProtKB/TrEMBL
  ENSSSCT00030006024.1 UniProtKB/TrEMBL
  ENSSSCT00035044344.1 UniProtKB/TrEMBL
  ENSSSCT00040024628.1 UniProtKB/TrEMBL
  ENSSSCT00045041284.1 UniProtKB/TrEMBL
  ENSSSCT00050023786.1 UniProtKB/TrEMBL
  ENSSSCT00055035930.1 UniProtKB/TrEMBL
  ENSSSCT00060054683.1 UniProtKB/TrEMBL
  ENSSSCT00065027259.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  SIG15 UniProtKB/TrEMBL
KEGG Report ssc:100518460 UniProtKB/TrEMBL
NCBI Gene SIGLEC15 ENTREZGENE
PANTHER PTHR46942 UniProtKB/TrEMBL
  SIALIC ACID-BINDING IG-LIKE LECTIN 15 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A5G2Q878 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0V9J9_PIG UniProtKB/TrEMBL
  A0A8D0ZGF1_PIG UniProtKB/TrEMBL
  A0A8D1DRX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IAJ2_PIG UniProtKB/TrEMBL
  F1RPU4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:92871 ENTREZGENE