TMEM63A (transmembrane protein 63A) - Rat Genome Database
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Gene: TMEM63A (transmembrane protein 63A) Sus scrofa
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Symbol: TMEM63A
Name: transmembrane protein 63A
RGD ID: 14254493
Description: ENCODES a protein that exhibits mechanosensitive ion channel activity (ortholog); osmolarity-sensing cation channel activity (ortholog); INVOLVED IN cation transmembrane transport (inferred); ion transport (inferred); ASSOCIATED WITH Disease Progression (ortholog); Hypomyelinating Leukodystrophy 19 (ortholog); leukodystrophy (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CSC1-like protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,769,603 - 13,814,020 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11013,771,795 - 13,814,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21015,975,250 - 16,015,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
TMEM63A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,769,603 - 13,814,020 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11013,771,795 - 13,814,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21015,975,250 - 16,015,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM63A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1225,845,536 - 225,882,380 (-)EnsemblGRCh38hg38GRCh38
GRCh381225,840,556 - 225,882,720 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,033,237 - 226,070,080 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371226,033,233 - 226,070,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,099,863 - 224,136,671 (-)NCBINCBI36hg18NCBI36
Celera1199,224,296 - 199,261,462 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1196,550,933 - 196,588,105 (-)NCBIHuRef
CHM1_11227,305,554 - 227,342,737 (-)NCBICHM1_1
Tmem63a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,766,992 - 180,802,671 (+)NCBIGRCm39mm39
GRCm381180,942,286 - 180,975,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,942,344 - 180,975,112 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,872,649 - 182,905,235 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,779,193 - 182,811,779 (+)NCBImm8
Celera1188,007,992 - 188,040,911 (+)NCBICelera
Cytogenetic Map1H4NCBI
Tmem63a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,662,872 - 92,696,186 (+)NCBI
Rnor_6.0 Ensembl1399,220,510 - 99,253,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01399,219,585 - 99,253,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013104,217,467 - 104,250,973 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,671,527 - 96,704,177 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,860,142 - 96,893,106 (+)NCBI
Celera1392,206,402 - 92,238,798 (+)NCBICelera
Cytogenetic Map13q26NCBI
TMEM63A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11206,302,729 - 206,344,760 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,307,554 - 206,343,458 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01201,306,608 - 201,344,627 (-)NCBIMhudiblu_PPA_v0panPan3
TMEM63A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl738,937,041 - 38,964,345 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1738,936,989 - 38,964,349 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmem63a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365262,653,556 - 2,690,427 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM63A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,887,535 - 3,924,422 (+)NCBI
ChlSab1.1 Ensembl253,890,581 - 3,922,944 (+)Ensembl


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 4
Low 10 4 3 4 2 19 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011876   ⟹   ENSSSCP00000011572
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1013,773,963 - 13,814,020 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000038160   ⟹   ENSSSCP00000033512
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1013,773,963 - 13,814,020 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000039484   ⟹   ENSSSCP00000041108
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1013,773,963 - 13,814,020 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000042074   ⟹   ENSSSCP00000053822
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1013,773,963 - 13,814,020 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053194   ⟹   ENSSSCP00000032451
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1013,769,603 - 13,807,206 (-)Ensembl
RefSeq Acc Id: NM_001243189   ⟹   NP_001230118
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,773,961 - 13,813,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653774   ⟹   XP_005653831
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,771,795 - 13,814,441 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653775   ⟹   XP_005653832
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,771,795 - 13,813,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653777   ⟹   XP_005653834
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,771,795 - 13,814,442 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013978258   ⟹   XP_013833712
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,771,795 - 13,814,442 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064006   ⟹   XP_020919665
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,771,795 - 13,814,441 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005653834   ⟸   XM_005653777
- Peptide Label: isoform X1
- UniProtKB: A0A286ZLG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013833712   ⟸   XM_013978258
- Peptide Label: isoform X1
- UniProtKB: A0A286ZLG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005653831   ⟸   XM_005653774
- Peptide Label: isoform X1
- UniProtKB: A0A286ZLG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919665   ⟸   XM_021064006
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005653832   ⟸   XM_005653775
- Peptide Label: isoform X1
- UniProtKB: A0A286ZLG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230118   ⟸   NM_001243189
- Sequence:
RefSeq Acc Id: ENSSSCP00000041108   ⟸   ENSSSCT00000039484
RefSeq Acc Id: ENSSSCP00000011572   ⟸   ENSSSCT00000011876
RefSeq Acc Id: ENSSSCP00000053822   ⟸   ENSSSCT00000042074
RefSeq Acc Id: ENSSSCP00000032451   ⟸   ENSSSCT00000053194
RefSeq Acc Id: ENSSSCP00000033512   ⟸   ENSSSCT00000038160
Protein Domains
PHM7_cyt   RSN1_7TM   RSN1_TM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010854 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011572 UniProtKB/TrEMBL
  ENSSSCP00000032451 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000033512 UniProtKB/TrEMBL
  ENSSSCP00000041108 UniProtKB/TrEMBL
  ENSSSCP00000053822 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011876 UniProtKB/TrEMBL
  ENSSSCT00000038160 UniProtKB/TrEMBL
  ENSSSCT00000039484 UniProtKB/TrEMBL
  ENSSSCT00000042074 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053194 ENTREZGENE, UniProtKB/TrEMBL
InterPro Csc1_N UniProtKB/TrEMBL
  PHM7_cyt UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RSN1_7TM UniProtKB/TrEMBL
  TMEM63A UniProtKB/TrEMBL
NCBI Gene TMEM63A ENTREZGENE
PANTHER PTHR13018:SF24 UniProtKB/TrEMBL
Pfam PHM7_cyt UniProtKB/TrEMBL
  RSN1_7TM UniProtKB/TrEMBL
  RSN1_TM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A286ZLG0 ENTREZGENE, UniProtKB/TrEMBL
  A0A286ZPW4_PIG UniProtKB/TrEMBL
  A0A287ABD9_PIG UniProtKB/TrEMBL
  F1S8R3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96198 ENTREZGENE