ZFHX3 (zinc finger homeobox 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: ZFHX3 (zinc finger homeobox 3) Sus scrofa
Analyze
Symbol: ZFHX3
Name: zinc finger homeobox 3
RGD ID: 14253790
Description: ENCODES a protein that exhibits transcription cis-regulatory region binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); negative regulation of myoblast differentiation (ortholog); positive regulation of cell adhesion (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); autism spectrum disorder (ortholog); autoimmune hepatitis (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: zinc finger homeobox protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl615,698,199 - 15,863,270 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1615,693,987 - 15,941,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2615,056,290 - 15,160,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ZFHX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl615,698,199 - 15,863,270 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1615,693,987 - 15,941,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2615,056,290 - 15,160,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFHX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,782,885 - 73,891,930 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,782,885 - 73,891,871 (-)EnsemblGRCh38hg38GRCh38
GRCh371672,816,784 - 73,925,829 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361671,374,285 - 71,639,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 341671,378,455 - 71,639,775NCBI
Celera1657,132,611 - 57,398,274 (-)NCBICelera
Cytogenetic Map16q22.2-q22.3NCBI
HuRef1658,584,915 - 58,866,797 (-)NCBIHuRef
CHM1_11674,229,746 - 74,505,362 (-)NCBICHM1_1
T2T-CHM13v2.01678,600,697 - 79,709,756 (-)NCBIT2T-CHM13v2.0
Zfhx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398109,005,975 - 109,688,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,669,276 - 109,688,262 (+)EnsemblGRCm39 Ensembl
GRCm388108,279,311 - 108,961,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,942,644 - 108,961,630 (+)EnsemblGRCm38mm10GRCm38
MGSCv378111,238,544 - 111,485,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368111,603,773 - 111,846,367 (+)NCBIMGSCv36mm8
Celera8112,939,113 - 113,186,662 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map856.02NCBI
Zfhx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,789,146 - 53,795,664 (+)NCBIGRCr8
mRatBN7.21936,257,196 - 36,886,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1936,630,254 - 36,881,771 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01942,753,983 - 42,925,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,758,127 - 42,920,344 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01953,580,987 - 53,764,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41938,547,428 - 38,783,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1936,050,820 - 36,295,322 (+)NCBICelera
Cytogenetic Map19q12NCBI
Zfhx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554845,474,769 - 5,789,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554845,470,203 - 5,746,325 (-)NCBIChiLan1.0ChiLan1.0
ZFHX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21881,085,000 - 81,357,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11687,015,073 - 87,287,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01651,936,471 - 52,209,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11672,631,428 - 72,895,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1672,635,666 - 72,808,360 (-)Ensemblpanpan1.1panPan2
ZFHX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1578,450,963 - 78,635,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl578,455,005 - 78,610,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha578,441,233 - 78,600,526 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,880,298 - 79,039,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,884,635 - 79,127,274 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,710,322 - 78,869,472 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0578,398,650 - 78,557,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0579,031,731 - 79,190,942 (-)NCBIUU_Cfam_GSD_1.0
Zfhx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934938,353,405 - 39,283,347 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,080,302 - 21,231,544 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,005,242 - 21,235,992 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFHX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,912,325 - 56,174,010 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,907,983 - 56,085,112 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604718,623,958 - 18,901,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfhx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474615,098,960 - 15,254,127 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474615,094,890 - 15,330,653 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZFHX3
6206 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 9 4 3 5 2 22 2 3 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003049   ⟹   ENSSSCP00000002970
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl615,698,199 - 15,863,270 (-)Ensembl
RefSeq Acc Id: XM_021097088   ⟹   XP_020952747
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1615,693,987 - 15,941,301 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020952747 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000002970
  ENSSSCP00000002970.4
  ENSSSCP00045016280.1
Reference Protein Sequences
RefSeq Acc Id: XP_020952747   ⟸   XM_021097088
- UniProtKB: A0A8D1HAL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002970   ⟸   ENSSSCT00000003049
Protein Domains
C2H2-type   Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00045013805 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003049 ENTREZGENE
  ENSSSCT00000003049.5 UniProtKB/TrEMBL
  ENSSSCT00045023579.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Matrin/U1-like-C_Znf_C2H2 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene ZFHX3 ENTREZGENE
PANTHER ZINC FINGER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  ZINC FINGER HOMEOBOX PROTEIN 3 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
  ZnF_U1 UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8D1HAL9 ENTREZGENE, UniProtKB/TrEMBL
  F1S397_PIG UniProtKB/TrEMBL
VGNC ID VGNC:95141 ENTREZGENE