ALPL (alkaline phosphatase, biomineralization associated) - Rat Genome Database

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Gene: ALPL (alkaline phosphatase, biomineralization associated) Sus scrofa
Analyze
Symbol: ALPL
Name: alkaline phosphatase, biomineralization associated
RGD ID: 14252241
Description: ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); calcium ion binding (ortholog); phosphoamidase activity (ortholog); INVOLVED IN biomineralization (ortholog); bone mineralization (ortholog); calcium ion homeostasis (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH adult hypophosphatasia (ortholog); Alveolar Bone Loss (ortholog); Animal Disease Models (ortholog); FOUND IN extracellular matrix (ortholog); extracellular membrane-bounded organelle (ortholog); extracellular space (ortholog); INTERACTS WITH Bisphenol A diglycidyl ether; dexamethasone; glycerol 2-phosphate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme; ALP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,589,045 - 79,649,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,589,695 - 79,649,646 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
ALPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,589,045 - 79,649,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,589,695 - 79,649,646 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,508,984 - 21,578,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl121,509,397 - 21,578,410 (+)EnsemblGRCh38hg38GRCh38
GRCh37121,835,477 - 21,904,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,708,445 - 21,777,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 34121,581,174 - 21,650,208NCBI
Celera120,158,568 - 20,227,624 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,079,620 - 20,148,672 (+)NCBIHuRef
CHM1_1121,947,891 - 22,016,920 (+)NCBICHM1_1
T2T-CHM13v2.0121,332,916 - 21,402,323 (+)NCBIT2T-CHM13v2.0
Alpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,469,042 - 137,523,695 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,469,044 - 137,523,695 (-)EnsemblGRCm39 Ensembl
GRCm384137,741,731 - 137,796,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,741,733 - 137,796,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,297,647 - 137,352,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,013,815 - 137,068,399 (-)NCBIMGSCv36mm8
Celera4135,949,159 - 136,007,413 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.02NCBI
Alpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,951,397 - 150,006,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,951,409 - 150,006,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,647,183 - 152,702,235 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05154,421,476 - 154,476,524 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05154,403,485 - 154,458,535 (-)NCBIRnor_WKY
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
RH 3.4 Map51009.6RGD
Cytogenetic Map5q36NCBI
Alpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,820,174 - 1,874,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,820,212 - 1,873,877 (+)NCBIChiLan1.0ChiLan1.0
ALPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1121,667,732 - 21,736,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,667,732 - 21,736,688 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0120,702,509 - 20,772,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ALPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,559,791 - 77,614,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,559,791 - 77,614,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,073,609 - 74,088,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,128,381 - 78,182,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,128,381 - 78,182,455 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,947,430 - 74,962,684 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,958,433 - 75,973,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,961,389 - 76,976,632 (-)NCBIUU_Cfam_GSD_1.0
Alpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,362,174 - 41,405,120 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364747,209,196 - 7,229,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,055,583 - 111,124,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,055,558 - 111,081,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,163,162 - 5,231,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,393,765 - 6,447,829 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,393,741 - 6,447,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 3 2 1 20 1
Below cutoff 7 2 3 4 1 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000055918   ⟹   ENSSSCP00000059419
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl679,589,045 - 79,649,644 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059407   ⟹   ENSSSCP00000058920
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl679,617,257 - 79,649,644 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000092095   ⟹   ENSSSCP00000081321
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl679,592,538 - 79,649,644 (+)Ensembl
RefSeq Acc Id: XM_021097681   ⟹   XP_020953340
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1679,627,703 - 79,649,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021097682   ⟹   XP_020953341
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1679,589,695 - 79,649,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021097683   ⟹   XP_020953342
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1679,617,259 - 79,649,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021097684   ⟹   XP_020953343
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1679,589,854 - 79,649,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021097685   ⟹   XP_020953344
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1679,617,259 - 79,649,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021097686   ⟹   XP_020953345
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1679,621,988 - 79,649,646 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020953341   ⟸   XM_021097682
- Peptide Label: isoform X2
- UniProtKB: A0A4X1W3F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953343   ⟸   XM_021097684
- Peptide Label: isoform X2
- UniProtKB: A0A4X1W3F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953342   ⟸   XM_021097683
- Peptide Label: isoform X2
- UniProtKB: A0A4X1W3F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953344   ⟸   XM_021097685
- Peptide Label: isoform X2
- UniProtKB: A0A4X1W3F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953345   ⟸   XM_021097686
- Peptide Label: isoform X2
- UniProtKB: A0A4X1W3F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953340   ⟸   XM_021097681
- Peptide Label: isoform X1
- UniProtKB: A0A480UBK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000059419   ⟸   ENSSSCT00000055918
RefSeq Acc Id: ENSSSCP00000058920   ⟸   ENSSSCT00000059407
RefSeq Acc Id: ENSSSCP00000081321   ⟸   ENSSSCT00000092095


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032607 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005020391 UniProtKB/TrEMBL
  ENSSSCG00015047671 UniProtKB/TrEMBL
  ENSSSCG00030052664 UniProtKB/TrEMBL
  ENSSSCG00040057106 UniProtKB/TrEMBL
  ENSSSCG00050078873 UniProtKB/TrEMBL
  ENSSSCG00055015471 UniProtKB/TrEMBL
  ENSSSCG00065047830 UniProtKB/TrEMBL
  ENSSSCG00070028721 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000058920 ENTREZGENE
  ENSSSCP00000058920.2 UniProtKB/TrEMBL
  ENSSSCP00000059419.2 UniProtKB/TrEMBL
  ENSSSCP00000081321 ENTREZGENE
  ENSSSCP00005019537.1 UniProtKB/TrEMBL
  ENSSSCP00005019587.1 UniProtKB/TrEMBL
  ENSSSCP00005019593.1 UniProtKB/TrEMBL
  ENSSSCP00015025564.1 UniProtKB/TrEMBL
  ENSSSCP00030033626.1 UniProtKB/TrEMBL
  ENSSSCP00040033337.1 UniProtKB/TrEMBL
  ENSSSCP00050048363.1 UniProtKB/TrEMBL
  ENSSSCP00055024358.1 UniProtKB/TrEMBL
  ENSSSCP00065028347.1 UniProtKB/TrEMBL
  ENSSSCP00070049001.1 UniProtKB/TrEMBL
  ENSSSCP00070049002.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000055918.2 UniProtKB/TrEMBL
  ENSSSCT00000059407 ENTREZGENE
  ENSSSCT00000059407.2 UniProtKB/TrEMBL
  ENSSSCT00000092095 ENTREZGENE
  ENSSSCT00005032063.1 UniProtKB/TrEMBL
  ENSSSCT00005032133.1 UniProtKB/TrEMBL
  ENSSSCT00005032141.1 UniProtKB/TrEMBL
  ENSSSCT00015063860.1 UniProtKB/TrEMBL
  ENSSSCT00030073504.1 UniProtKB/TrEMBL
  ENSSSCT00040077493.1 UniProtKB/TrEMBL
  ENSSSCT00050108824.1 UniProtKB/TrEMBL
  ENSSSCT00055030599.1 UniProtKB/TrEMBL
  ENSSSCT00065065436.1 UniProtKB/TrEMBL
  ENSSSCT00070057643.1 UniProtKB/TrEMBL
  ENSSSCT00070057645.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
NCBI Gene ALPL ENTREZGENE
PANTHER PTHR11596 UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/TrEMBL
PRINTS ALKPHPHTASE UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/TrEMBL
SMART alkPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
UniProt A0A287BSC3_PIG UniProtKB/TrEMBL
  A0A480UBK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VYS3_PIG UniProtKB/TrEMBL
  A0A4X1W3F8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85269 ENTREZGENE