PLEKHS1 (pleckstrin homology domain containing S1) - Rat Genome Database

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Gene: PLEKHS1 (pleckstrin homology domain containing S1) Sus scrofa
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Symbol: PLEKHS1
Name: pleckstrin homology domain containing S1
RGD ID: 14248040
Description: ASSOCIATED WITH disease of cellular proliferation (ortholog); genetic disease (ortholog); glucose intolerance (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family S member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,068,263 - 124,103,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114124,068,099 - 124,104,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

Genomics

Comparative Map Data
PLEKHS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,068,263 - 124,103,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114124,068,099 - 124,104,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLEKHS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810113,751,682 - 113,783,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10113,751,262 - 113,783,429 (+)EnsemblGRCh38hg38GRCh38
GRCh3710115,511,441 - 115,543,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,501,203 - 115,532,181 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410115,501,202 - 115,532,181NCBI
Celera10109,238,565 - 109,269,575 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10109,139,023 - 109,169,611 (+)NCBIHuRef
CHM1_110115,793,257 - 115,824,244 (+)NCBICHM1_1
T2T-CHM13v2.010114,643,537 - 114,675,061 (+)NCBIT2T-CHM13v2.0
Plekhs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,445,705 - 56,475,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1956,450,072 - 56,475,184 (+)EnsemblGRCm39 Ensembl
GRCm381956,457,275 - 56,486,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,461,640 - 56,486,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv371956,536,127 - 56,561,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361956,514,890 - 56,539,975 (+)NCBIMGSCv36mm8
Celera1958,649,118 - 58,674,285 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.86NCBI
Plekhs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81265,500,524 - 265,533,352 (+)NCBIGRCr8
mRatBN7.21255,495,634 - 255,525,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,495,634 - 255,525,353 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1263,705,127 - 263,735,141 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,411,166 - 270,441,179 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,057,573 - 263,087,651 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,261,493 - 277,294,194 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,261,681 - 277,291,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01284,642,569 - 284,675,151 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,740,491 - 262,770,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1251,194,966 - 251,224,961 (+)NCBICelera
Cytogenetic Map1q55NCBI
Plekhs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543118,745,791 - 18,770,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543118,745,990 - 18,798,517 (+)NCBIChiLan1.0ChiLan1.0
PLEKHS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28125,651,317 - 125,664,713 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110125,656,653 - 125,670,049 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010110,350,571 - 110,382,677 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110113,784,348 - 113,813,542 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10113,784,348 - 113,813,542 (+)Ensemblpanpan1.1panPan2
PLEKHS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12824,643,803 - 24,685,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2824,644,330 - 24,664,807 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2824,795,150 - 24,837,272 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02825,175,603 - 25,217,742 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2825,176,136 - 25,197,227 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12824,732,939 - 24,775,037 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02824,741,107 - 24,789,753 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02824,947,047 - 24,982,622 (+)NCBIUU_Cfam_GSD_1.0
Plekhs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721321,402,316 - 21,427,464 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364864,130,463 - 4,159,710 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364864,130,916 - 4,159,110 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19106,641,332 - 106,654,595 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604867,842,331 - 67,873,135 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473732,810,212 - 32,835,258 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473732,810,663 - 32,835,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLEKHS1
796 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system renal system reproductive system respiratory system
High
Medium 2
Low 3 2 4 1 1
Below cutoff 4 1 1 2 1 2

Sequence


RefSeq Acc Id: ENSSSCT00000054130   ⟹   ENSSSCP00000049046
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14124,068,263 - 124,103,909 (+)Ensembl
RefSeq Acc Id: XM_021073324   ⟹   XP_020928983
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114124,068,106 - 124,104,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073325   ⟹   XP_020928984
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114124,070,190 - 124,104,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073326   ⟹   XP_020928985
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114124,068,112 - 124,104,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073327   ⟹   XP_020928986
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114124,068,112 - 124,104,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073328   ⟹   XP_020928987
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114124,068,099 - 124,104,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073329   ⟹   XP_020928988
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114124,068,190 - 124,104,042 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020928987   ⟸   XM_021073328
- Peptide Label: isoform X4
- UniProtKB: A0A4X1T6B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928983   ⟸   XM_021073324
- Peptide Label: isoform X1
- UniProtKB: A0A4X1T6B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928986   ⟸   XM_021073327
- Peptide Label: isoform X3
- UniProtKB: A0A4X1T6B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928985   ⟸   XM_021073326
- Peptide Label: isoform X2
- UniProtKB: A0A4X1T6B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928988   ⟸   XM_021073329
- Peptide Label: isoform X5
- UniProtKB: A0A287AYU6 (UniProtKB/TrEMBL),   A0A4X1T6B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928984   ⟸   XM_021073325
- Peptide Label: isoform X1
- UniProtKB: A0A4X1T6B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000049046   ⟸   ENSSSCT00000054130
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034754 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025020765 UniProtKB/TrEMBL
  ENSSSCG00065056014 UniProtKB/TrEMBL
  ENSSSCG00070006555 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000054130 ENTREZGENE
  ENSSSCT00000054130.3 UniProtKB/TrEMBL
  ENSSSCT00025028201.1 UniProtKB/TrEMBL
  ENSSSCT00065076711.1 UniProtKB/TrEMBL
  ENSSSCT00070012537.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PLEKHS1 UniProtKB/TrEMBL
NCBI Gene PLEKHS1 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY S MEMBER 1 UniProtKB/TrEMBL
  PTHR47014 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A287AYU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T6B4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91555 ENTREZGENE