SREBF2 (sterol regulatory element binding transcription factor 2) - Rat Genome Database

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Gene: SREBF2 (sterol regulatory element binding transcription factor 2) Sus scrofa
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Symbol: SREBF2
Name: sterol regulatory element binding transcription factor 2
RGD ID: 14245787
Description: ENCODES a protein that exhibits C-8 sterol isomerase activity (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN aging (ortholog); cholesterol homeostasis (ortholog); negative regulation of cholesterol efflux (ortholog); PARTICIPATES IN altered p53 signaling pathway; sterol regulatory element-binding protein signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); carotid artery disease (ortholog); cholelithiasis (ortholog); FOUND IN cytoplasm (ortholog); dendrite (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH ezetimibe; simvastatin
Type: protein-coding
RefSeq Status: MODEL
Also known as: SREBP-2; sterol regulatory element binding protein 2; sterol regulatory element-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,719,487 - 6,784,672 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,719,484 - 6,784,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ezetimibe  (EXP)
simvastatin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11160371   PMID:16167998   PMID:16303770   PMID:23825667  


Genomics

Comparative Map Data
SREBF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,719,487 - 6,784,672 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,719,484 - 6,784,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SREBF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2241,833,079 - 41,907,307 (+)EnsemblGRCh38hg38GRCh38
GRCh382241,833,105 - 41,907,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372242,229,109 - 42,303,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,559,052 - 40,632,321 (+)NCBINCBI36hg18NCBI36
Build 342240,553,605 - 40,626,873NCBI
Celera2226,035,175 - 26,108,609 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2225,194,635 - 25,269,011 (+)NCBIHuRef
CHM1_12242,189,135 - 42,263,520 (+)NCBICHM1_1
Srebf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,031,470 - 82,089,580 (+)NCBIGRCm39mm39
GRCm39 Ensembl1582,031,382 - 82,089,580 (+)Ensembl
GRCm381582,147,269 - 82,205,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,147,181 - 82,205,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,977,699 - 82,035,390 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,974,524 - 82,032,215 (+)NCBImm8
Celera1584,270,919 - 84,328,680 (+)NCBICelera
Cytogenetic Map15E1NCBI
Srebf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27113,663,202 - 113,720,850 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7113,663,202 - 113,720,848 (+)Ensembl
Rnor_6.07123,381,082 - 123,438,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,381,077 - 123,438,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,364,495 - 123,422,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,522,511 - 120,580,212 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17120,556,723 - 120,612,972 (+)NCBI
Celera7109,978,519 - 110,036,018 (+)NCBICelera
Cytogenetic Map7q34NCBI
Srebf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541327,271,953 - 27,326,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541327,271,717 - 27,326,655 (+)NCBIChiLan1.0ChiLan1.0
SREBF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12240,811,459 - 40,884,947 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,811,459 - 40,884,947 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02222,725,790 - 22,799,749 (+)NCBIMhudiblu_PPA_v0panPan3
Srebf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,105,519 - 7,164,174 (-)NCBI
SpeTri2.0NW_004936492115,923 - 174,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREBF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11924,364,725 - 24,439,851 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1924,364,911 - 24,440,014 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045100,972,400 - 101,047,348 (-)NCBIVero_WHO_p1.0
Srebf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247526,815,075 - 6,871,674 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 7 1 1
Low 7 4 3 3 2 16 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000023268   ⟹   ENSSSCP00000021509
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl56,719,487 - 6,784,672 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000038734   ⟹   ENSSSCP00000057081
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl56,721,533 - 6,763,156 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000056933   ⟹   ENSSSCP00000053362
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl56,719,487 - 6,784,672 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000085009   ⟹   ENSSSCP00000060961
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl56,744,606 - 6,763,156 (-)Ensembl
RefSeq Acc Id: XM_021091444   ⟹   XP_020947103
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.156,719,484 - 6,784,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021091445   ⟹   XP_020947104
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.156,719,484 - 6,784,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021091446   ⟹   XP_020947105
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.156,719,484 - 6,784,341 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020947103   ⟸   XM_021091444
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020947104   ⟸   XM_021091445
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020947105   ⟸   XM_021091446
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000060961   ⟸   ENSSSCT00000085009
RefSeq Acc Id: ENSSSCP00000053362   ⟸   ENSSSCT00000056933
RefSeq Acc Id: ENSSSCP00000057081   ⟸   ENSSSCT00000038734
RefSeq Acc Id: ENSSSCP00000021509   ⟸   ENSSSCT00000023268
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026092 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070028488 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000021509 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000053362 UniProtKB/TrEMBL
  ENSSSCP00000057081 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000060961 UniProtKB/TrEMBL
  ENSSSCP00070048560 UniProtKB/TrEMBL
  ENSSSCP00070048564 UniProtKB/TrEMBL
  ENSSSCP00070048570 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000023268 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000038734 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000056933 UniProtKB/TrEMBL
  ENSSSCT00000085009 UniProtKB/TrEMBL
  ENSSSCT00070057131 UniProtKB/TrEMBL
  ENSSSCT00070057135 UniProtKB/TrEMBL
  ENSSSCT00070057141 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene SREBF2 ENTREZGENE
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A287BBC2_PIG UniProtKB/TrEMBL
  A0A287BL07_PIG UniProtKB/TrEMBL
  A0A4X1W273_PIG UniProtKB/TrEMBL
  A0A4X1W4W8_PIG UniProtKB/TrEMBL
  A0A4X1W4X1_PIG UniProtKB/TrEMBL
  A0A5G2QAD2_PIG UniProtKB/TrEMBL
  I3LBT7_PIG UniProtKB/TrEMBL
UniProt Secondary K9IW92 UniProtKB/TrEMBL
VGNC ID VGNC:93450 ENTREZGENE