FOXF1 (forkhead box F1) - Rat Genome Database

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Gene: FOXF1 (forkhead box F1) Sus scrofa
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Symbol: FOXF1
Name: forkhead box F1
RGD ID: 14244921
Description: ENCODES a protein that exhibits DNA binding (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); blood vessel development (ortholog); cell-cell adhesion (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); gastrointestinal stromal tumor (ortholog); mastocytosis (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: forkhead box protein F1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl62,592,993 - 2,597,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.162,579,348 - 2,598,122 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,799,092 - 2,801,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IBA,ISO)
blood vessel development  (ISO)
cardiac left ventricle morphogenesis  (IEA)
cell-cell adhesion  (IEA,ISO)
cellular response to cytokine stimulus  (IEA,ISO)
cellular response to organic cyclic compound  (IEA,ISO)
detection of wounding  (IEA,ISO)
determination of left/right symmetry  (IEA,ISO)
digestive tract development  (ISO)
ductus arteriosus closure  (IEA)
embryonic digestive tract development  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic ectodermal digestive tract morphogenesis  (IEA)
embryonic foregut morphogenesis  (IEA,ISO)
endocardial cushion development  (IEA)
epithelial cell differentiation involved in mammary gland alveolus development  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
establishment of epithelial cell apical/basal polarity  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
heart development  (ISO)
in utero embryonic development  (IEA,ISO)
lateral mesodermal cell differentiation  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
lung lobe morphogenesis  (IEA,ISO)
lung morphogenesis  (ISO)
lung vasculature development  (IEA)
mesenchyme migration  (IEA,ISO)
mesoderm development  (ISO)
midgut development  (IEA)
morphogenesis of a branching structure  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of mast cell degranulation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
pancreas development  (IEA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell-substrate adhesion  (IEA,ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
respiratory tube development  (ISO)
right lung morphogenesis  (IEA,ISO)
smooth muscle cell differentiation  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
somitogenesis  (IEA,ISO)
trachea development  (IEA,ISO)
ureter development  (IEA)
vasculogenesis  (IEA,ISO)
venous blood vessel development  (IEA)

Cellular Component
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
FOXF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl62,592,993 - 2,597,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.162,579,348 - 2,598,122 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,799,092 - 2,801,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1686,510,527 - 86,515,422 (+)EnsemblGRCh38hg38GRCh38
GRCh381686,510,527 - 86,515,422 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371686,544,133 - 86,549,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,101,634 - 85,105,571 (+)NCBINCBI36hg18NCBI36
Build 341685,101,658 - 85,105,548NCBI
Celera1670,844,972 - 70,848,909 (+)NCBI
Cytogenetic Map16q24.1NCBI
HuRef1672,283,842 - 72,287,779 (+)NCBIHuRef
CHM1_11687,955,849 - 87,959,786 (+)NCBICHM1_1
Foxf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398121,811,125 - 121,814,893 (+)NCBIGRCm39mm39
GRCm39 Ensembl8121,811,125 - 121,814,883 (+)Ensembl
GRCm388121,084,386 - 121,088,154 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,084,386 - 121,088,144 (+)EnsemblGRCm38mm10GRCm38
MGSCv378123,608,374 - 123,610,779 (+)NCBIGRCm37mm9NCBIm37
MGSCv368123,970,451 - 123,972,856 (+)NCBImm8
Celera8125,302,426 - 125,304,831 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.31NCBI
Foxf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21949,153,729 - 49,157,741 (+)NCBI
Rnor_6.0 Ensembl1953,012,332 - 53,016,086 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01953,012,306 - 53,016,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01963,756,636 - 63,760,430 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1948,400,056 - 48,404,066 (+)NCBICelera
Cytogenetic Map19q12NCBI
Foxf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555411,317,114 - 1,346,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555411,341,715 - 1,345,397 (+)NCBIChiLan1.0ChiLan1.0
FOXF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11686,515,150 - 86,519,949 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1686,516,119 - 86,519,949 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01667,183,416 - 67,188,211 (+)NCBIMhudiblu_PPA_v0panPan3
FOXF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1566,343,776 - 66,347,785 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,345,150 - 66,347,935 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha566,355,810 - 66,359,808 (-)NCBI
ROS_Cfam_1.0566,565,325 - 66,569,328 (-)NCBI
UMICH_Zoey_3.1566,588,163 - 66,592,141 (-)NCBI
UNSW_CanFamBas_1.0566,423,363 - 66,427,352 (-)NCBI
UU_Cfam_GSD_1.0566,836,698 - 66,840,702 (-)NCBI
Foxf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244082614 - 1,756 (-)NCBI
SpeTri2.0NW_0049438834 - 1,756 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1571,898,473 - 71,902,624 (+)NCBI
ChlSab1.1 Ensembl571,898,786 - 71,903,661 (+)Ensembl
Vero_WHO_p1.0NW_0236660473,803,343 - 3,807,492 (-)NCBI
Foxf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247462,599,211 - 2,603,031 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 5 1 2 1
Below cutoff 1 2 3 1 20 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000040450   ⟹   ENSSSCP00000042203
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl62,592,993 - 2,597,336 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045590   ⟹   ENSSSCP00000037013
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl62,592,993 - 2,597,659 (-)Ensembl
RefSeq Acc Id: XM_021093695   ⟹   XP_020949354
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.162,579,348 - 2,598,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093696   ⟹   XP_020949355
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.162,579,348 - 2,598,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093697   ⟹   XP_020949356
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.162,579,348 - 2,598,122 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020949354 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949355 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949356 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020949356   ⟸   XM_021093697
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020949355   ⟸   XM_021093696
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020949354   ⟸   XM_021093695
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000042203   ⟸   ENSSSCT00000040450
RefSeq Acc Id: ENSSSCP00000037013   ⟸   ENSSSCT00000045590
Protein Domains
Fork-head


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038460 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070007086 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000037013 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000042203 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070011215 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040450 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045590 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070013604 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Fork_head_dom UniProtKB/TrEMBL
  TF_fork_head_CS_1 UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene FOXF1 ENTREZGENE
Pfam Forkhead UniProtKB/TrEMBL
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_1 UniProtKB/TrEMBL
  FORK_HEAD_2 UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/TrEMBL
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A286ZZE6_PIG UniProtKB/TrEMBL
  A0A287ADW4_PIG UniProtKB/TrEMBL
  A0A4X1T7Q3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88204 ENTREZGENE