KLHL8 (kelch like family member 8) - Rat Genome Database

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Gene: KLHL8 (kelch like family member 8) Sus scrofa
Analyze
Symbol: KLHL8
Name: kelch like family member 8
RGD ID: 14236603
Description: INVOLVED IN protein ubiquitination (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 8; kelch-like protein 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,634,209 - 131,700,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,634,171 - 131,701,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,909,603 - 140,931,918 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,634,209 - 131,700,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,634,171 - 131,701,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,909,603 - 140,931,918 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,160,103 - 87,240,531 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,160,103 - 87,240,314 (-)EnsemblGRCh38hg38GRCh38
GRCh37488,081,255 - 88,141,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,301,238 - 88,360,698 (-)NCBINCBI36Build 36hg18NCBI36
Build 34488,439,392 - 88,498,853NCBI
Celera485,371,231 - 85,430,685 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef483,826,503 - 83,885,876 (-)NCBIHuRef
CHM1_1488,059,619 - 88,119,078 (-)NCBICHM1_1
T2T-CHM13v2.0490,489,165 - 90,569,763 (-)NCBIT2T-CHM13v2.0
Klhl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,009,916 - 104,059,137 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,009,839 - 104,059,125 (-)EnsemblGRCm39 Ensembl
GRCm385103,862,050 - 103,911,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5103,861,973 - 103,911,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv375104,291,069 - 104,340,248 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,102,352 - 104,151,531 (-)NCBIMGSCv36mm8
Celera5101,168,123 - 101,217,145 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.45NCBI
Klhl8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,112,472 - 6,158,001 (+)NCBIGRCr8
mRatBN7.2145,807,795 - 5,853,325 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,807,907 - 5,853,294 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,775,288 - 5,820,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,075,516 - 7,121,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,773,843 - 5,819,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,169,517 - 7,215,025 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,169,519 - 7,215,025 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0147,159,371 - 7,204,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,958,124 - 7,003,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,978,904 - 7,003,611 (+)NCBI
Celera145,946,794 - 5,992,070 (+)NCBICelera
Cytogenetic Map14p22NCBI
Klhl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554742,652,992 - 2,710,616 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554742,652,992 - 2,710,616 (+)NCBIChiLan1.0ChiLan1.0
KLHL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,176,525 - 85,236,648 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,438,568 - 85,498,966 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,462,540 - 79,522,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,190,302 - 90,247,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,190,302 - 90,225,284 (-)Ensemblpanpan1.1panPan2
KLHL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13210,656,419 - 10,687,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3210,659,240 - 10,686,998 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3231,224,842 - 31,297,941 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03210,710,493 - 10,781,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3210,708,476 - 10,739,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13210,790,068 - 10,862,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,617,500 - 10,690,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03229,264,169 - 29,337,281 (+)NCBIUU_Cfam_GSD_1.0
Klhl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405285556,977 - 576,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049369204,186 - 25,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049369204,418 - 22,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,535,406 - 35,614,934 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl735,535,230 - 35,595,201 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603714,226,547 - 14,306,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248723,677,397 - 3,750,867 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248723,675,248 - 3,750,852 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLHL8
3018 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010105   ⟹   ENSSSCP00000009839
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8131,634,209 - 131,700,068 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057387   ⟹   ENSSSCP00000058844
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8131,663,673 - 131,700,068 (+)Ensembl
RefSeq Acc Id: XM_021101776   ⟹   XP_020957435
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18131,634,171 - 131,701,161 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101777   ⟹   XP_020957436
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18131,658,675 - 131,701,161 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101778   ⟹   XP_020957437
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18131,663,764 - 131,701,161 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021101779   ⟹   XP_020957438
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18131,634,187 - 131,701,161 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020957435   ⟸   XM_021101776
- Peptide Label: isoform X1
- UniProtKB: A0A4X1U1F7 (UniProtKB/TrEMBL),   F1RW26 (UniProtKB/TrEMBL),   A0A8D1ANY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020957438   ⟸   XM_021101779
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020957436   ⟸   XM_021101777
- Peptide Label: isoform X1
- UniProtKB: A0A4X1U1F7 (UniProtKB/TrEMBL),   F1RW26 (UniProtKB/TrEMBL),   A0A8D1ANY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020957437   ⟸   XM_021101778
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000009839   ⟸   ENSSSCT00000010105
RefSeq Acc Id: ENSSSCP00000058844   ⟸   ENSSSCT00000057387
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005021822 UniProtKB/TrEMBL
  ENSSSCG00015007934 UniProtKB/TrEMBL
  ENSSSCG00025036166 UniProtKB/TrEMBL
  ENSSSCG00030036960 UniProtKB/TrEMBL
  ENSSSCG00035066192 UniProtKB/TrEMBL
  ENSSSCG00045013717 UniProtKB/TrEMBL
  ENSSSCG00050038087 UniProtKB/TrEMBL
  ENSSSCG00055023025 UniProtKB/TrEMBL
  ENSSSCG00060040619 UniProtKB/TrEMBL
  ENSSSCG00065076750 UniProtKB/TrEMBL
  ENSSSCG00070014398 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010105 ENTREZGENE
  ENSSSCT00000010105.5 UniProtKB/TrEMBL
  ENSSSCT00000057387.3 UniProtKB/TrEMBL
  ENSSSCT00005034539.1 UniProtKB/TrEMBL
  ENSSSCT00005034560.1 UniProtKB/TrEMBL
  ENSSSCT00005034589.1 UniProtKB/TrEMBL
  ENSSSCT00015010586.1 UniProtKB/TrEMBL
  ENSSSCT00015010798.1 UniProtKB/TrEMBL
  ENSSSCT00025049321.1 UniProtKB/TrEMBL
  ENSSSCT00025049330.1 UniProtKB/TrEMBL
  ENSSSCT00030051557.1 UniProtKB/TrEMBL
  ENSSSCT00030051616.1 UniProtKB/TrEMBL
  ENSSSCT00035089292.1 UniProtKB/TrEMBL
  ENSSSCT00035089433.1 UniProtKB/TrEMBL
  ENSSSCT00045023415.1 UniProtKB/TrEMBL
  ENSSSCT00045023443.1 UniProtKB/TrEMBL
  ENSSSCT00045023453.1 UniProtKB/TrEMBL
  ENSSSCT00045023459.1 UniProtKB/TrEMBL
  ENSSSCT00045023470.1 UniProtKB/TrEMBL
  ENSSSCT00045023489.1 UniProtKB/TrEMBL
  ENSSSCT00050051408.1 UniProtKB/TrEMBL
  ENSSSCT00055045685.1 UniProtKB/TrEMBL
  ENSSSCT00055045952.1 UniProtKB/TrEMBL
  ENSSSCT00060055046.1 UniProtKB/TrEMBL
  ENSSSCT00060055075.1 UniProtKB/TrEMBL
  ENSSSCT00065106078.1 UniProtKB/TrEMBL
  ENSSSCT00065106103.1 UniProtKB/TrEMBL
  ENSSSCT00070028253.1 UniProtKB/TrEMBL
  ENSSSCT00070028260.1 UniProtKB/TrEMBL
  ENSSSCT00070028276.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene KLHL8 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  BTB DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
  LD33804P UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A4X1U1F7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U6S4_PIG UniProtKB/TrEMBL
  A0A8D0IZ86_PIG UniProtKB/TrEMBL
  A0A8D1ANY1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2A607_PIG UniProtKB/TrEMBL
  F1RW26 ENTREZGENE
UniProt Secondary A0A287BQX4 UniProtKB/TrEMBL
  F1RW26 UniProtKB/TrEMBL
VGNC ID VGNC:89536 ENTREZGENE