ITGA3 (integrin subunit alpha 3) - Rat Genome Database

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Gene: ITGA3 (integrin subunit alpha 3) Sus scrofa
Analyze
Symbol: ITGA3
Name: integrin subunit alpha 3
RGD ID: 14232864
Description: ENCODES a protein that exhibits collagen binding (ortholog); fibronectin binding (ortholog); integrin binding (ortholog); INVOLVED IN cell adhesion (ortholog); dendritic spine maintenance (ortholog); exploration behavior (ortholog); PARTICIPATES IN altered Reelin signaling pathway; integrin mediated signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH anemia (ortholog); bronchopulmonary dysplasia (ortholog); Cardiomegaly (ortholog); FOUND IN cell surface (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin alpha-3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,235,258 - 26,269,324 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,234,769 - 26,269,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,288,983 - 26,308,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ITGA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,235,258 - 26,269,324 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,234,769 - 26,269,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,288,983 - 26,308,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,056,110 - 50,090,481 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,055,968 - 50,090,481 (+)EnsemblGRCh38hg38GRCh38
GRCh371748,133,474 - 48,167,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,488,730 - 45,522,843 (+)NCBINCBI36Build 36hg18NCBI36
Build 341745,488,729 - 45,522,843NCBI
Celera1744,591,582 - 44,627,962 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,500,496 - 43,535,731 (+)NCBIHuRef
CHM1_11748,197,214 - 48,232,155 (+)NCBICHM1_1
T2T-CHM13v2.01750,921,575 - 50,957,585 (+)NCBIT2T-CHM13v2.0
Itga3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,935,301 - 94,967,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,935,300 - 94,967,627 (-)EnsemblGRCm39 Ensembl
GRCm381195,044,475 - 95,076,844 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,044,474 - 95,076,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,905,796 - 94,938,028 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,860,572 - 94,892,804 (-)NCBIMGSCv36mm8
Celera11104,654,874 - 104,687,668 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Itga3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,486,998 - 80,522,548 (-)NCBIGRCr8
mRatBN7.21079,990,160 - 80,022,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,990,161 - 80,022,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,939,254 - 84,971,203 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,437,323 - 84,469,271 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,830,424 - 79,862,336 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,855,841 - 82,887,755 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,855,613 - 82,887,497 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,666,856 - 82,698,319 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,728,710 - 83,759,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,744,399 - 83,774,825 (-)NCBI
Celera1078,763,866 - 78,796,174 (-)NCBICelera
Cytogenetic Map10q26NCBI
Itga3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,561,704 - 11,589,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,563,120 - 11,590,119 (-)NCBIChiLan1.0ChiLan1.0
ITGA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,243,873 - 66,279,253 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,050,327 - 71,085,737 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,145,974 - 44,181,343 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,019,889 - 49,055,245 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,019,892 - 49,055,245 (+)Ensemblpanpan1.1panPan2
ITGA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,065,792 - 26,095,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,062,393 - 26,094,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,458,998 - 25,488,798 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,860,362 - 26,890,161 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,856,943 - 26,890,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,628,148 - 25,657,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,886,765 - 25,916,569 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,016,729 - 26,046,536 (+)NCBIUU_Cfam_GSD_1.0
Itga3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,491,793 - 25,521,235 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,553,861 - 11,583,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,553,904 - 11,583,387 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,248,341 - 43,282,045 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,250,435 - 43,281,670 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,964,390 - 13,998,162 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,062,290 - 6,092,557 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,062,438 - 6,092,556 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ITGA3
1310 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 3 3 21 2 3 1
Below cutoff 4 2 1 2 1

Sequence


RefSeq Acc Id: ENSSSCT00000019136   ⟹   ENSSSCP00000018630
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1226,235,258 - 26,269,324 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000034265   ⟹   ENSSSCP00000028475
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1226,234,753 - 26,271,561 (+)Ensembl
RefSeq Acc Id: XM_021067145   ⟹   XP_020922804
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11226,234,769 - 26,269,327 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020922804 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000018630
  ENSSSCP00000018630.4
RefSeq Acc Id: XP_020922804   ⟸   XM_021067145
- UniProtKB: A0A480ZI48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000028475   ⟸   ENSSSCT00000034265
RefSeq Acc Id: ENSSSCP00000018630   ⟸   ENSSSCT00000019136

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019136 ENTREZGENE
  ENSSSCT00000019136.4 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
NCBI Gene ITGA3 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-3 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A480ZI48 ENTREZGENE, UniProtKB/TrEMBL
  F1RT62_PIG UniProtKB/TrEMBL
UniProt Secondary K7GNL6 UniProtKB/TrEMBL
VGNC ID VGNC:89235 ENTREZGENE