PREPL (prolyl endopeptidase like) - Rat Genome Database

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Gene: PREPL (prolyl endopeptidase like) Sus scrofa
Analyze
Symbol: PREPL
Name: prolyl endopeptidase like
RGD ID: 14228436
Description: ENCODES a protein that exhibits peptidase activity (inferred); serine-type endopeptidase activity (inferred); serine-type peptidase activity (inferred); INVOLVED IN Golgi to plasma membrane protein transport (inferred); proteolysis (inferred); regulation of synaptic vesicle exocytosis (inferred); ASSOCIATED WITH congenital myasthenic syndrome (ortholog); congenital myasthenic syndrome 22 (ortholog); cystinuria (ortholog); FOUND IN cytoskeleton (inferred); cytosol (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prolyl endopeptidase-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,092,314 - 96,159,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,248,639 - 102,314,853 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PREPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,092,314 - 96,159,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,248,639 - 102,314,853 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PREPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,317,607 - 44,361,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl244,316,281 - 44,361,862 (-)EnsemblGRCh38hg38GRCh38
GRCh37244,544,746 - 44,589,001 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,399,406 - 44,440,393 (-)NCBINCBI36Build 36hg18NCBI36
Celera244,383,700 - 44,427,951 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef244,281,407 - 44,325,655 (-)NCBIHuRef
CHM1_1244,472,451 - 44,516,684 (-)NCBICHM1_1
T2T-CHM13v2.0244,322,928 - 44,367,164 (-)NCBIT2T-CHM13v2.0
Prepl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,370,122 - 85,397,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,370,898 - 85,397,669 (-)EnsemblGRCm39 Ensembl
GRCm381785,062,511 - 85,090,504 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1785,063,470 - 85,090,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv371785,462,817 - 85,489,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361784,971,812 - 84,998,534 (-)NCBIMGSCv36mm8
Celera1789,425,166 - 89,451,900 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.19NCBI
Prepl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,333,107 - 15,362,825 (+)NCBIGRCr8
mRatBN7.269,580,367 - 9,609,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx69,869,516 - 9,898,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,178,893 - 10,208,191 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,700,429 - 9,729,763 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,316,861 - 8,346,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,318,979 - 8,346,197 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,249,345 - 8,278,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,419,874 - 8,447,739 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,419,873 - 8,447,739 (-)NCBI
Celera69,304,799 - 9,331,994 (+)NCBICelera
Cytogenetic Map6q12NCBI
Prepl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,418,299 - 11,453,218 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544111,418,299 - 11,453,889 (-)NCBIChiLan1.0ChiLan1.0
PREPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,044,665 - 82,090,876 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,048,635 - 82,094,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A44,417,735 - 44,463,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,353,326 - 45,398,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A45,353,326 - 45,397,903 (-)Ensemblpanpan1.1panPan2
PREPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,733,769 - 46,792,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,726,676 - 46,792,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,595,349 - 46,654,047 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01047,613,473 - 47,672,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,613,473 - 47,672,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11047,320,610 - 47,379,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,611,662 - 47,670,468 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,794,300 - 47,853,142 (-)NCBIUU_Cfam_GSD_1.0
Prepl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,209,248 - 36,243,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365087,637,882 - 7,674,877 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365087,637,844 - 7,674,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11462,879,616 - 62,925,265 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1462,875,133 - 62,924,746 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604548,954,858 - 49,006,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prepl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,802,793 - 25,834,762 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473825,802,156 - 25,835,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PREPL
2593 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 3 3 4 2 23 2 3
Low 8 1 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009250   ⟹   ENSSSCP00000009016
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044527   ⟹   ENSSSCP00000059137
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050817   ⟹   ENSSSCP00000036036
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081950   ⟹   ENSSSCP00000061313
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl396,092,334 - 96,159,531 (+)Ensembl
RefSeq Acc Id: XM_003125176   ⟹   XP_003125224
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,092,333 - 96,159,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005655232   ⟹   XP_005655289
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,092,333 - 96,159,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005655233   ⟹   XP_005655290
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,092,314 - 96,159,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005655235   ⟹   XP_005655292
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,092,334 - 96,159,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021088299   ⟹   XP_020943958
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,092,334 - 96,159,436 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021088300   ⟹   XP_020943959
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,092,334 - 96,159,436 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002342961
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1396,092,333 - 96,159,533 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003125224 (Get FASTA)   NCBI Sequence Viewer  
  XP_005655289 (Get FASTA)   NCBI Sequence Viewer  
  XP_005655290 (Get FASTA)   NCBI Sequence Viewer  
  XP_005655292 (Get FASTA)   NCBI Sequence Viewer  
  XP_020943958 (Get FASTA)   NCBI Sequence Viewer  
  XP_020943959 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000009016
  ENSSSCP00000009016.3
  ENSSSCP00000036036.2
  ENSSSCP00000059137.2
  ENSSSCP00005011899.1
  ENSSSCP00005011926.1
  ENSSSCP00005012073.1
  ENSSSCP00005012099.1
  ENSSSCP00015021235.1
  ENSSSCP00015021366.1
  ENSSSCP00015021468.1
  ENSSSCP00025018416.1
  ENSSSCP00025018458.1
  ENSSSCP00025018516.1
  ENSSSCP00025018559.1
  ENSSSCP00030021732.1
  ENSSSCP00030021741.1
  ENSSSCP00030021796.1
  ENSSSCP00035032768.1
  ENSSSCP00035032778.1
  ENSSSCP00035032788.1
  ENSSSCP00040003353.1
  ENSSSCP00040003362.1
  ENSSSCP00040003368.1
  ENSSSCP00040003371.1
  ENSSSCP00040003379.1
  ENSSSCP00045039914.1
  ENSSSCP00045039989.1
  ENSSSCP00045040063.1
  ENSSSCP00045040209.1
  ENSSSCP00050008427.1
  ENSSSCP00050008430.1
  ENSSSCP00050008440.1
  ENSSSCP00050008453.1
  ENSSSCP00060028413.1
  ENSSSCP00065023350.1
  ENSSSCP00065023360.1
  ENSSSCP00065023364.1
  ENSSSCP00065023366.1
  ENSSSCP00065023367.1
  ENSSSCP00070002468.1
  ENSSSCP00070002472.1
  ENSSSCP00070002489.1
  ENSSSCP00070002501.1
  ENSSSCP00070002505.1
Reference Protein Sequences
RefSeq Acc Id: XP_005655290   ⟸   XM_005655233
- Peptide Label: isoform X2
- UniProtKB: A0A4X1SJF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005655289   ⟸   XM_005655232
- Peptide Label: isoform X1
- UniProtKB: F1S5K3 (UniProtKB/TrEMBL),   A0A4X1SK85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003125224   ⟸   XM_003125176
- Peptide Label: isoform X1
- UniProtKB: F1S5K3 (UniProtKB/TrEMBL),   A0A4X1SK85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005655292   ⟸   XM_005655235
- Peptide Label: isoform X2
- UniProtKB: A0A4X1SJF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020943958   ⟸   XM_021088299
- Peptide Label: isoform X2
- UniProtKB: A0A4X1SJF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020943959   ⟸   XM_021088300
- Peptide Label: isoform X3
- UniProtKB: A0A4X1SJF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009016   ⟸   ENSSSCT00000009250
RefSeq Acc Id: ENSSSCP00000059137   ⟸   ENSSSCT00000044527
RefSeq Acc Id: ENSSSCP00000036036   ⟸   ENSSSCT00000050817
RefSeq Acc Id: ENSSSCP00000061313   ⟸   ENSSSCT00000081950
Protein Domains
Peptidase S9 prolyl oligopeptidase catalytic   Peptidase S9A N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008448 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005012575 UniProtKB/TrEMBL
  ENSSSCG00015039156 UniProtKB/TrEMBL
  ENSSSCG00025031860 UniProtKB/TrEMBL
  ENSSSCG00030034756 UniProtKB/TrEMBL
  ENSSSCG00035059475 UniProtKB/TrEMBL
  ENSSSCG00040006453 UniProtKB/TrEMBL
  ENSSSCG00045033378 UniProtKB/TrEMBL
  ENSSSCG00050014934 UniProtKB/TrEMBL
  ENSSSCG00060048848 UniProtKB/TrEMBL
  ENSSSCG00065039279 UniProtKB/TrEMBL
  ENSSSCG00070001599 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009250 ENTREZGENE
  ENSSSCT00000009250.5 UniProtKB/TrEMBL
  ENSSSCT00000044527.3 UniProtKB/TrEMBL
  ENSSSCT00000050817.3 UniProtKB/TrEMBL
  ENSSSCT00005019708.1 UniProtKB/TrEMBL
  ENSSSCT00005019758.1 UniProtKB/TrEMBL
  ENSSSCT00005020042.1 UniProtKB/TrEMBL
  ENSSSCT00005020111.1 UniProtKB/TrEMBL
  ENSSSCT00015053029.1 UniProtKB/TrEMBL
  ENSSSCT00015053305.1 UniProtKB/TrEMBL
  ENSSSCT00015053549.1 UniProtKB/TrEMBL
  ENSSSCT00025043303.1 UniProtKB/TrEMBL
  ENSSSCT00025043420.1 UniProtKB/TrEMBL
  ENSSSCT00025043554.1 UniProtKB/TrEMBL
  ENSSSCT00025043663.1 UniProtKB/TrEMBL
  ENSSSCT00030048151.1 UniProtKB/TrEMBL
  ENSSSCT00030048168.1 UniProtKB/TrEMBL
  ENSSSCT00030048257.1 UniProtKB/TrEMBL
  ENSSSCT00035079697.1 UniProtKB/TrEMBL
  ENSSSCT00035079712.1 UniProtKB/TrEMBL
  ENSSSCT00035079728.1 UniProtKB/TrEMBL
  ENSSSCT00040008558.1 UniProtKB/TrEMBL
  ENSSSCT00040008586.1 UniProtKB/TrEMBL
  ENSSSCT00040008608.1 UniProtKB/TrEMBL
  ENSSSCT00040008615.1 UniProtKB/TrEMBL
  ENSSSCT00040008628.1 UniProtKB/TrEMBL
  ENSSSCT00045057121.1 UniProtKB/TrEMBL
  ENSSSCT00045057212.1 UniProtKB/TrEMBL
  ENSSSCT00045057312.1 UniProtKB/TrEMBL
  ENSSSCT00045057494.1 UniProtKB/TrEMBL
  ENSSSCT00050020226.1 UniProtKB/TrEMBL
  ENSSSCT00050020232.1 UniProtKB/TrEMBL
  ENSSSCT00050020259.1 UniProtKB/TrEMBL
  ENSSSCT00050020289.1 UniProtKB/TrEMBL
  ENSSSCT00060066345.1 UniProtKB/TrEMBL
  ENSSSCT00065053705.1 UniProtKB/TrEMBL
  ENSSSCT00065053721.1 UniProtKB/TrEMBL
  ENSSSCT00065053735.1 UniProtKB/TrEMBL
  ENSSSCT00065053739.1 UniProtKB/TrEMBL
  ENSSSCT00065053741.1 UniProtKB/TrEMBL
  ENSSSCT00070002998.1 UniProtKB/TrEMBL
  ENSSSCT00070003007.1 UniProtKB/TrEMBL
  ENSSSCT00070003024.1 UniProtKB/TrEMBL
  ENSSSCT00070003037.1 UniProtKB/TrEMBL
  ENSSSCT00070003042.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
  Prolyl oligopeptidase, N-terminal domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Pept_S9A_N UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
  Peptidase_S9A UniProtKB/TrEMBL
KEGG Report ssc:100526165 UniProtKB/TrEMBL
NCBI Gene PREPL ENTREZGENE
PANTHER PROLYL ENDOPEPTIDASE-LIKE UniProtKB/TrEMBL
  PROTEASE FAMILY S9A OLIGOPEPTIDASE UniProtKB/TrEMBL
Pfam Peptidase_S9 UniProtKB/TrEMBL
  Peptidase_S9_N UniProtKB/TrEMBL
PRINTS PROLIGOPTASE UniProtKB/TrEMBL
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A286ZWZ9_PIG UniProtKB/TrEMBL
  A0A287BSJ0_PIG UniProtKB/TrEMBL
  A0A4X1SJF6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SJI3_PIG UniProtKB/TrEMBL
  A0A4X1SK85 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SK99_PIG UniProtKB/TrEMBL
  A0A8D0IHE5_PIG UniProtKB/TrEMBL
  A0A8D0ILK5_PIG UniProtKB/TrEMBL
  A0A8D0IQJ1_PIG UniProtKB/TrEMBL
  A0A8D0LI72_PIG UniProtKB/TrEMBL
  A0A8D1ALE4_PIG UniProtKB/TrEMBL
  A0A8D1APF9_PIG UniProtKB/TrEMBL
  A0A8D1ARI1_PIG UniProtKB/TrEMBL
  A0A8D1BV56_PIG UniProtKB/TrEMBL
  A0A8D2C7I8_PIG UniProtKB/TrEMBL
  F1S5K3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91790 ENTREZGENE