DKK2 (dickkopf WNT signaling pathway inhibitor 2) - Rat Genome Database

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Gene: DKK2 (dickkopf WNT signaling pathway inhibitor 2) Sus scrofa
Analyze
Symbol: DKK2
Name: dickkopf WNT signaling pathway inhibitor 2
RGD ID: 14225890
Description: ENCODES a protein that exhibits co-receptor binding (inferred); receptor antagonist activity (inferred); INVOLVED IN negative regulation of canonical Wnt signaling pathway (inferred); negative regulation of Wnt signaling pathway (inferred); positive regulation of canonical Wnt signaling pathway (inferred); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dickkopf-related protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8114,862,247 - 114,974,304 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18114,862,056 - 114,974,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28123,169,059 - 123,280,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DKK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8114,862,247 - 114,974,304 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18114,862,056 - 114,974,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28123,169,059 - 123,280,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384106,921,802 - 107,036,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4106,921,802 - 107,283,806 (-)EnsemblGRCh38hg38GRCh38
GRCh374107,842,959 - 107,957,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364108,062,408 - 108,176,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 344108,200,564 - 108,315,057NCBI
Celera4105,142,017 - 105,256,526 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4103,577,892 - 103,692,398 (-)NCBIHuRef
CHM1_14107,819,993 - 107,934,463 (-)NCBICHM1_1
T2T-CHM13v2.04110,226,876 - 110,341,391 (-)NCBIT2T-CHM13v2.0
Dkk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393131,791,027 - 131,886,065 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3131,791,053 - 131,886,065 (+)EnsemblGRCm39 Ensembl
GRCm383132,085,266 - 132,180,304 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3132,085,292 - 132,180,304 (+)EnsemblGRCm38mm10GRCm38
MGSCv373131,748,256 - 131,843,268 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363132,022,607 - 132,117,610 (+)NCBIMGSCv36mm8
Celera3138,511,569 - 138,606,576 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.32NCBI
Dkk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82223,242,375 - 223,334,249 (+)NCBIGRCr8
mRatBN7.22220,568,338 - 220,660,225 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2220,568,338 - 220,660,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2228,216,913 - 228,308,598 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02226,116,586 - 226,208,267 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,974,246 - 221,065,929 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02237,148,918 - 237,240,883 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2237,148,941 - 237,241,350 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02255,689,579 - 255,781,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42229,542,203 - 229,634,156 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12229,529,344 - 229,619,963 (+)NCBI
Celera2212,811,245 - 212,902,656 (+)NCBICelera
Cytogenetic Map2q43NCBI
Dkk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554962,489,373 - 2,578,639 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554962,489,373 - 2,578,310 (+)NCBIChiLan1.0ChiLan1.0
DKK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23105,015,174 - 105,130,173 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14105,316,460 - 105,431,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0499,428,210 - 99,542,884 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14110,002,933 - 110,117,159 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4110,001,499 - 110,117,326 (-)Ensemblpanpan1.1panPan2
DKK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13227,548,877 - 27,647,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3227,550,833 - 27,713,838 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3214,380,145 - 14,478,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03227,778,999 - 27,877,746 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3227,779,000 - 27,877,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13227,773,574 - 27,872,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03227,516,644 - 27,615,395 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03212,241,851 - 12,340,868 (+)NCBIUU_Cfam_GSD_1.0
Dkk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530113,467,767 - 13,563,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936814184,832 - 282,633 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936814184,625 - 280,945 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1754,875,611 - 54,982,310 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl754,875,627 - 54,982,300 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603733,521,289 - 33,628,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248302,093,797 - 2,186,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248302,093,481 - 2,186,497 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DKK2
2938 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 2 1
Low 3 3 2 3 16 2 1
Below cutoff 7 1 1 3 2

Sequence


RefSeq Acc Id: ENSSSCT00000058233   ⟹   ENSSSCP00000045342
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8114,862,247 - 114,974,304 (+)Ensembl
RefSeq Acc Id: XM_003129269   ⟹   XP_003129317
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18114,862,056 - 114,974,327 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003129317   ⟸   XM_003129269
- UniProtKB: A0A287AN69 (UniProtKB/TrEMBL),   A0A4X1UUA8 (UniProtKB/TrEMBL),   A0A8D0N2C9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000045342   ⟸   ENSSSCT00000058233

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032094 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005041072 UniProtKB/TrEMBL
  ENSSSCG00015021425 UniProtKB/TrEMBL
  ENSSSCG00025043481 UniProtKB/TrEMBL
  ENSSSCG00030002840 UniProtKB/TrEMBL
  ENSSSCG00035025066 UniProtKB/TrEMBL
  ENSSSCG00040063989 UniProtKB/TrEMBL
  ENSSSCG00045002855 UniProtKB/TrEMBL
  ENSSSCG00055006517 UniProtKB/TrEMBL
  ENSSSCG00060040780 UniProtKB/TrEMBL
  ENSSSCG00065005295 UniProtKB/TrEMBL
  ENSSSCG00070019506 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000058233 ENTREZGENE
  ENSSSCT00000058233.3 UniProtKB/TrEMBL
  ENSSSCT00005065814.1 UniProtKB/TrEMBL
  ENSSSCT00015028287.1 UniProtKB/TrEMBL
  ENSSSCT00025058963.1 UniProtKB/TrEMBL
  ENSSSCT00030003631.1 UniProtKB/TrEMBL
  ENSSSCT00035032981.1 UniProtKB/TrEMBL
  ENSSSCT00040087379.1 UniProtKB/TrEMBL
  ENSSSCT00045004505.1 UniProtKB/TrEMBL
  ENSSSCT00055012605.1 UniProtKB/TrEMBL
  ENSSSCT00060055256.1 UniProtKB/TrEMBL
  ENSSSCT00065007176.1 UniProtKB/TrEMBL
  ENSSSCT00070038568.1 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom1 UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom2 UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk2_Cys1 UniProtKB/TrEMBL
  Dkk2_Cys2 UniProtKB/TrEMBL
KEGG Report ssc:100519672 UniProtKB/TrEMBL
NCBI Gene DKK2 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 2 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom1 UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom2 UniProtKB/TrEMBL
UniProt A0A287AN69 ENTREZGENE
  A0A4X1UUA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0N2C9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287AN69 UniProtKB/TrEMBL
VGNC ID VGNC:87322 ENTREZGENE