OSBP2 (oxysterol binding protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: OSBP2 (oxysterol binding protein 2) Sus scrofa
Analyze
Symbol: OSBP2
Name: oxysterol binding protein 2
RGD ID: 14220277
Description: ENCODES a protein that exhibits cholesterol binding (inferred); lipid binding (inferred); INVOLVED IN spermatid development (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); genetic disease (ortholog); FOUND IN apical dendrite (inferred); cytosol (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: oxysterol-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,551,516 - 47,737,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,558,088 - 47,737,994 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,722,089 - 50,849,216 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
OSBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,551,516 - 47,737,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,558,088 - 47,737,994 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,722,089 - 50,849,216 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OSBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,693,782 - 30,907,813 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,693,782 - 30,907,824 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,089,769 - 31,303,800 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,420,793 - 29,633,811 (+)NCBINCBI36Build 36hg18NCBI36
Build 342229,415,418 - 29,628,361NCBI
Celera2214,890,919 - 15,103,949 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,053,259 - 14,266,343 (+)NCBIHuRef
CHM1_12231,050,352 - 31,263,683 (+)NCBICHM1_1
T2T-CHM13v2.02231,157,371 - 31,371,381 (+)NCBIT2T-CHM13v2.0
Osbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,653,731 - 3,814,000 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,653,731 - 3,813,903 (-)EnsemblGRCm39 Ensembl
GRCm38113,703,731 - 3,863,999 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,703,731 - 3,863,903 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,603,734 - 3,763,906 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,603,734 - 3,763,906 (-)NCBIMGSCv36mm8
Celera114,194,917 - 4,357,599 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.6NCBI
Osbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,808,693 - 82,970,386 (-)NCBIGRCr8
mRatBN7.21478,585,088 - 78,746,785 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,585,089 - 78,746,786 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,026,235 - 83,187,793 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,266,325 - 84,427,879 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,712,116 - 80,873,790 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,943,976 - 84,107,031 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,943,977 - 84,106,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,628,869 - 84,790,722 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,350,465 - 84,511,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,370,976 - 84,530,872 (-)NCBI
Celera1477,497,341 - 77,658,805 (-)NCBICelera
Cytogenetic Map14q21NCBI
Osbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,928,207 - 5,110,999 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,928,153 - 5,110,178 (+)NCBIChiLan1.0ChiLan1.0
OSBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,651,570 - 40,879,575 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,292,848 - 43,583,185 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,719,017 - 11,933,841 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,521,404 - 29,734,538 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,520,479 - 29,733,061 (+)Ensemblpanpan1.1panPan2
OSBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,742,191 - 23,938,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,739,648 - 23,936,562 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,596,775 - 23,808,901 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,110,309 - 24,320,764 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,144,156 - 24,320,760 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,811,711 - 24,024,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,074,345 - 24,286,254 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,134,926 - 24,347,108 (+)NCBIUU_Cfam_GSD_1.0
Osbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,686,109 - 116,863,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493675531,009 - 121,887 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493675531,113 - 120,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,576,331 - 13,817,628 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,762,503 - 13,798,702 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,303,238 - 112,545,443 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Osbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247477,097,558 - 7,358,692 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OSBP2
3411 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system reproductive system
High
Medium 6
Low 3 17 1
Below cutoff 5 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010972   ⟹   ENSSSCP00000010686
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,557,193 - 47,737,993 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067410   ⟹   ENSSSCP00000061392
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,551,516 - 47,737,997 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081623   ⟹   ENSSSCP00000059656
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,638,568 - 47,737,987 (+)Ensembl
RefSeq Acc Id: XM_021072949   ⟹   XP_020928608
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,558,088 - 47,737,994 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020928608 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000059656.1
  ENSSSCP00000061392.2
  ENSSSCP00050047119.1
  ENSSSCP00060043595.1
Reference Protein Sequences
RefSeq Acc Id: XP_020928608   ⟸   XM_021072949
- UniProtKB: A0A8D1WRX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010686   ⟸   ENSSSCT00000010972
RefSeq Acc Id: ENSSSCP00000059656   ⟸   ENSSSCT00000081623
RefSeq Acc Id: ENSSSCP00000061392   ⟸   ENSSSCT00000067410
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010015 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00050077491 UniProtKB/TrEMBL
  ENSSSCG00060073393 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000067410.2 UniProtKB/TrEMBL
  ENSSSCT00000081623.2 UniProtKB/TrEMBL
  ENSSSCT00050106681.1 UniProtKB/TrEMBL
  ENSSSCT00060100394.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.40.160.120 UniProtKB/TrEMBL
InterPro OSBP_sf UniProtKB/TrEMBL
  Oxysterol-bd UniProtKB/TrEMBL
  Oxysterol-bd_CS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene OSBP2 ENTREZGENE
PANTHER OXYSTEROL-BINDING PROTEIN 2 UniProtKB/TrEMBL
  PTHR10972 UniProtKB/TrEMBL
Pfam Oxysterol_BP UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PROSITE OSBP UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF144000 UniProtKB/TrEMBL
UniProt A0A5G2QAH5_PIG UniProtKB/TrEMBL
  A0A5G2QMW5_PIG UniProtKB/TrEMBL
  A0A8D1WRX3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91067 ENTREZGENE