CNGA4 (cyclic nucleotide gated channel subunit alpha 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CNGA4 (cyclic nucleotide gated channel subunit alpha 4) Sus scrofa
Analyze
Symbol: CNGA4
Name: cyclic nucleotide gated channel subunit alpha 4
RGD ID: 14215266
Description: ENCODES a protein that exhibits cGMP binding (ortholog); intracellularly cAMP-activated cation channel activity (ortholog); intracellularly cGMP-activated cation channel activity (ortholog); INVOLVED IN sensory perception of smell (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH genetic disease (ortholog); neuronal ceroid lipofuscinosis (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); perikaryon (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclic nucleotide gated channel alpha 4; cyclic nucleotide-gated cation channel alpha-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,431,340 - 3,442,426 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,430,995 - 3,438,411 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.294,133,006 - 4,138,939 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CNGA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,431,340 - 3,442,426 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,430,995 - 3,438,411 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.294,133,006 - 4,138,939 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNGA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,234,793 - 6,244,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,234,765 - 6,244,479 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,260,319 - 6,265,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,216,910 - 6,222,235 (+)NCBINCBI36Build 36hg18NCBI36
Celera116,379,405 - 6,384,782 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef115,920,393 - 5,925,778 (+)NCBIHuRef
CHM1_1116,259,550 - 6,264,935 (+)NCBICHM1_1
T2T-CHM13v2.0116,293,180 - 6,303,456 (+)NCBIT2T-CHM13v2.0
Cnga4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,049,247 - 105,057,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,053,775 - 105,057,949 (+)EnsemblGRCm39 Ensembl
GRCm387105,400,024 - 105,408,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,404,568 - 105,408,742 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,553,082 - 112,557,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,278,389 - 105,282,559 (+)NCBIMGSCv36mm8
Celera7105,676,665 - 105,680,835 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.85NCBI
Cnga4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,134,332 - 169,168,317 (+)NCBIGRCr8
mRatBN7.21159,752,357 - 159,756,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,752,357 - 159,756,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,773,767 - 167,777,745 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,959,758 - 174,963,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,855,020 - 167,858,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,238,959 - 170,246,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,242,846 - 170,246,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,245,757 - 177,253,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,137,544 - 163,141,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,233,020 - 163,237,158 (+)NCBI
Celera1157,687,159 - 157,691,171 (+)NCBICelera
Cytogenetic Map1q32NCBI
Cnga4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541421,977,996 - 21,986,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541421,977,996 - 21,986,349 (+)NCBIChiLan1.0ChiLan1.0
CNGA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v298,673,844 - 8,686,515 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,637,699 - 8,647,964 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,368,768 - 6,378,976 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,051,091 - 6,061,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,051,091 - 6,061,550 (+)Ensemblpanpan1.1panPan2
CNGA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,575,140 - 29,581,721 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,575,578 - 29,580,616 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,273,213 - 29,293,243 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,397,346 - 30,417,377 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,402,030 - 30,407,489 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12129,722,659 - 29,738,374 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02129,884,350 - 29,904,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,078,976 - 30,098,988 (+)NCBIUU_Cfam_GSD_1.0
Cnga4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,360,294 - 56,369,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842310,741 - 314,754 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936842310,741 - 314,754 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNGA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,581,702 - 58,592,733 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,582,175 - 58,588,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,418,620 - 156,428,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnga4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248177,719,332 - 7,737,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248177,716,951 - 7,732,177 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CNGA4
340 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system nervous system
High
Medium
Low
Below cutoff 1 2 2 3

Sequence


RefSeq Acc Id: ENSSSCT00000015981   ⟹   ENSSSCP00000015560
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl93,431,340 - 3,442,426 (-)Ensembl
RefSeq Acc Id: XM_003129461   ⟹   XP_003129509
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.193,430,996 - 3,438,411 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021062349   ⟹   XP_020918008
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.193,430,995 - 3,438,411 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020918008   ⟸   XM_021062349
- Peptide Label: isoform X2
- UniProtKB: A0A8D0Q4W6 (UniProtKB/TrEMBL),   A0A8D1CYN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003129509   ⟸   XM_003129461
- Peptide Label: isoform X1
- UniProtKB: A0A8D1UWC4 (UniProtKB/TrEMBL),   F1RMM3 (UniProtKB/TrEMBL),   A0A8D0Q4W6 (UniProtKB/TrEMBL),   A0A8D1CYN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000015560   ⟸   ENSSSCT00000015981
Protein Domains
Cyclic nucleotide-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014630 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015073725 UniProtKB/TrEMBL
  ENSSSCG00030004318 UniProtKB/TrEMBL
  ENSSSCG00035056842 UniProtKB/TrEMBL
  ENSSSCG00045026562 UniProtKB/TrEMBL
  ENSSSCG00050070317 UniProtKB/TrEMBL
  ENSSSCG00060026488 UniProtKB/TrEMBL
  ENSSSCG00065078637 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015981 ENTREZGENE
  ENSSSCT00000015981.4 UniProtKB/TrEMBL
  ENSSSCT00015099157.1 UniProtKB/TrEMBL
  ENSSSCT00030005691.1 UniProtKB/TrEMBL
  ENSSSCT00035075982.1 UniProtKB/TrEMBL
  ENSSSCT00045045190.1 UniProtKB/TrEMBL
  ENSSSCT00050095855.1 UniProtKB/TrEMBL
  ENSSSCT00060035851.1 UniProtKB/TrEMBL
  ENSSSCT00065109115.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.5.300 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro CLZ_dom UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
KEGG Report ssc:100519325 UniProtKB/TrEMBL
NCBI Gene CNGA4 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-4 UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A UniProtKB/TrEMBL
Pfam CLZ UniProtKB/TrEMBL
  cNMP_binding UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PRINTS EAGCHANLFMLY UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8D0Q4W6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CYN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UWC4 ENTREZGENE, UniProtKB/TrEMBL
  F1RMM3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86818 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-25 CNGA4  cyclic nucleotide gated channel subunit alpha 4  CNGA4  cyclic nucleotide gated channel alpha 4  Symbol and/or name change 5135510 APPROVED