PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3) - Rat Genome Database

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Gene: PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3) Sus scrofa
Analyze
Symbol: PLEKHH3
Name: pleckstrin homology, MyTH4 and FERM domain containing H3
RGD ID: 14212475
Description: INVOLVED IN signal transduction (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family H member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,159,773 - 20,170,776 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,162,075 - 20,170,809 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,364,945 - 20,374,488 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoskeleton  (IEA)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PLEKHH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,159,773 - 20,170,776 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,162,075 - 20,170,809 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,364,945 - 20,374,488 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,667,914 - 42,676,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,667,914 - 42,676,994 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,819,932 - 40,829,012 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,073,458 - 38,082,495 (-)NCBINCBI36Build 36hg18NCBI36
Celera1737,475,397 - 37,484,507 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,584,959 - 36,594,114 (-)NCBIHuRef
CHM1_11741,055,686 - 41,064,687 (-)NCBICHM1_1
T2T-CHM13v2.01743,525,053 - 43,534,132 (-)NCBIT2T-CHM13v2.0
Plekhh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,053,505 - 101,062,205 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,053,505 - 101,062,177 (-)EnsemblGRCm39 Ensembl
GRCm3811101,162,679 - 101,171,378 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,162,679 - 101,171,351 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,023,993 - 101,032,616 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,978,769 - 100,987,392 (-)NCBIMGSCv36mm8
Celera11112,458,780 - 112,467,423 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.32NCBI
Plekhh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,598,749 - 86,607,482 (-)NCBIGRCr8
mRatBN7.21086,098,461 - 86,106,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,098,469 - 86,106,880 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,134,865 - 91,143,291 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,613,705 - 90,622,120 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,006,862 - 86,015,277 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,076,467 - 89,084,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,076,472 - 89,084,885 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,874,963 - 88,883,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,183,689 - 90,192,105 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,198,058 - 90,206,442 (-)NCBI
Celera1084,816,035 - 84,824,454 (-)NCBICelera
Cytogenetic Map10q31NCBI
Plekhh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,524,017 - 16,531,440 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,523,822 - 16,531,563 (-)NCBIChiLan1.0ChiLan1.0
PLEKHH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,308,012 - 22,317,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,198,014 - 24,207,352 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,640,115 - 14,649,223 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,864,374 - 14,873,284 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,864,857 - 14,873,076 (+)Ensemblpanpan1.1panPan2
PLEKHH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,313,325 - 20,321,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,313,191 - 20,321,142 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,774,626 - 19,783,084 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,031,706 - 21,040,165 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,032,163 - 21,040,134 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,817,626 - 19,826,081 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,082,806 - 20,091,257 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,186,825 - 20,195,283 (+)NCBIUU_Cfam_GSD_1.0
Plekhh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,667,292 - 19,676,213 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,397,493 - 17,407,908 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,398,926 - 17,407,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,612,527 - 63,621,292 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,612,989 - 63,624,694 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,405,629 - 34,414,413 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,486,452 - 1,494,073 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLEKHH3
163 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 8 4 3 5 2 16 2 3 1
Below cutoff 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018931   ⟹   ENSSSCP00000018426
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,159,773 - 20,170,776 (+)Ensembl
RefSeq Acc Id: XM_003358036   ⟹   XP_003358084
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,162,075 - 20,170,809 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003358084 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000018426
  ENSSSCP00000018426.4
  ENSSSCP00070020938.1
Reference Protein Sequences
RefSeq Acc Id: XP_003358084   ⟸   XM_003358036
- UniProtKB: A0A4X1TZW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000018426   ⟸   ENSSSCT00000018931
Protein Domains
FERM   MyTH4   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017391 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070012902 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018931 ENTREZGENE
  ENSSSCT00000018931.4 UniProtKB/TrEMBL
  ENSSSCT00070025271.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  1.25.40.530 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  MyTH4_dom UniProtKB/TrEMBL
  MyTH4_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
NCBI Gene PLEKHH3 ENTREZGENE
PANTHER AGAP003327-PA UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  PF00788 UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  MYTH4 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
UniProt A0A4X1TZW0 ENTREZGENE, UniProtKB/TrEMBL
  F1S1F1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91550 ENTREZGENE