FSCN3 (fascin actin-bundling protein 3)

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Gene: FSCN3 (fascin actin-bundling protein 3) Sus scrofa

Analyze

Symbol:

FSCN3

Name:

fascin actin-bundling protein 3

RGD ID:

14202631

Description:

ENCODES a protein that exhibits protein-macromolecule adaptor activity (inferred); INVOLVED IN spermatid development (inferred); ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

fascin 3; fascin homolog 3, actin-bundling protein, testicular; fascin-3

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	20,686,746 - 20,693,552 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	20,684,621 - 20,693,552 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	21,688,295 - 21,697,317 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (IBA)

cell migration (IBA)

establishment or maintenance of cell polarity (IBA)

spermatid development (IEA)

Cellular Component

actin cytoskeleton (IBA)

cell projection membrane (IBA)

cytoplasm (IBA,ISO)

filopodium (IBA)

growth cone (IBA)

lamellipodium (IBA)

microvillus (IBA)

ruffle (IBA)

Molecular Function

actin filament binding (IBA)

protein-macromolecule adaptor activity (IEA)

References

Additional References at PubMed

PMID:17065803

Genomics

Comparative Map Data

FSCN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	20,686,746 - 20,693,552 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	20,684,621 - 20,693,552 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	21,688,295 - 21,697,317 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FSCN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	7	127,591,409 - 127,602,144 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	7	127,593,736 - 127,602,144 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	7	127,233,790 - 127,242,198 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	7	127,233,689 - 127,241,851 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	127,020,925 - 127,029,079 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	7	126,827,639 - 126,835,794	NCBI
Celera	7	122,037,417 - 122,045,564 (+)	NCBI
Cytogenetic Map	7	q32.1	NCBI
HuRef	7	121,594,759 - 121,602,743 (+)	NCBI		HuRef
CHM1_1	7	127,166,986 - 127,175,152 (+)	NCBI		CHM1_1
CRA_TCAGchr7v2	7	126,617,134 - 126,625,289 (+)	NCBI

Fscn3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	28,427,869 - 28,438,621 (+)	NCBI	GRCm39		mm39
GRCm38	6	28,427,870 - 28,438,622 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	28,427,789 - 28,438,622 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	28,377,901 - 28,388,622 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	28,377,911 - 28,388,632 (+)	NCBI			mm8
Celera	6	28,434,941 - 28,445,662 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI

Fscn3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	57,042,797 - 57,052,224 (+)	NCBI
Rnor_6.0 Ensembl	4	55,720,010 - 55,729,457 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	55,719,976 - 55,729,442 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	55,467,449 - 55,476,891 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	55,298,103 - 55,307,523 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	55,548,259 - 55,557,678 (+)	NCBI
Celera	4	52,154,383 - 52,163,752 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

Fscn3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955479	8,648,582 - 8,654,493 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955479	8,649,022 - 8,656,899 (+)	NCBI	ChiLan1.0	ChiLan1.0

FSCN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	132,244,268 - 132,252,312 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	132,244,268 - 132,250,913 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	119,589,219 - 119,597,360 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

FSCN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	14	8,722,069 - 8,730,729 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	14	8,719,857 - 8,730,881 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Fscn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936479	14,794,876 - 14,803,549 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FSCN3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	96,407,983 - 96,416,313 (+)	NCBI
ChlSab1.1 Ensembl	21	96,409,005 - 96,414,922 (+)	Ensembl

Fscn3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624783	8,345,467 - 8,356,973 (-)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	reproductive system
High
Medium
Low
Below cutoff	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU861978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ324422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000018064 ⟹ ENSSSCP00000017576

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	18	20,686,746 - 20,693,552 (-)	Ensembl

RefSeq Acc Id:

NM_001044547 ⟹ NP_001038012

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	18	20,684,621 - 20,693,552 (-)	NCBI

Sequence:

show sequence

GTGGGTACCAAAGGCCTGATTCCAGGCCCTATGGCCTGTGGAACCTCACCCCTGGGGGGAAGGC
TGGGCCGGACAGAGACATCTCCTGTGGCACCGGCCGCATGGATGAGGCGGAGTGGACGCCAAGA
CCAGCCAGGGCAGAGGACCTAAGGGTTGGGCTCATCAGCTGGGCAGGATCCTACCTCACTTTTG
AGACATATAAGAACACGGTCACTGCTACTGCCAAGGGTTTGGGCCGGAGACAGACCTGGGAAAT
CCTAGTGAGCAACGAGCATGATGCACAGGCTATGGTGCGACTAAGAAGCTTGCAAGGCCTCTAT
CTTCTGTGTGAGGCAGATGGTTCCCTGTGCTACGGCCGGCCAAGAACGAGCCATCATGGATGCT
TCCTCCTCCGTTTTCACCGCAATGGCAAATGGACCCTCCAGTGCATCATCAGTGGTCGTTATCT
GGAGTCTGATGGCGAGGATGTTTTCTGCACCTCCCGGGTCCTCTCAGCTTACCACATGTGGACC
CCTCGGCCAGCCCTGCATGTCCACGTGATCCTCTACAGCCCCCTCAACCGCTGCTATGCCCGGG
CTGACCCCACCATGGGCCGAGTCTGGGTGGATGCACCGGTTCCCTGCCTGGAGGAATGTGGCTT
CCTGTTGCATTTCCAGGATGGATGCTACCACCTGGAGACCTCTGCACACACCTTCTTGTCTCAC
TTAGACCGGCTGGTCTCCCAGCCCTCAACACAGACAGCTTTCCACATGCAAGTGCGACCTGGAG
GGCTTGTGGCACTGAGCGATGGAGAGGGGGGCACGTTGTATCCTCAGGGTACACGCCTGCTCCT
GGGTCTGGGCTCCAGTCCCTGTGGGGGTGAGGAGTGGTTCATCCTACAGCGCTGCCCTACCTGG
GTCAGCCTCAGGTCAAAGACTCGGAAGTTTCTCTCCATCGTCTATGATGTTGAGGTGTGCGCTG
CCTCTGAGCACATAACCCCCATGTCCTTGTTCCAGTTTGAGTGTAACAATGAGAGCCCCAATGT
GCAGCTTCGTTCCTCCAATGGCTGCTACCTTGTCCAGAGGCGCCATAGGACAGTGATGGCTGAT
GGGCACCCACTGGAGTCTGACACCTTCTTTCGTATGCACTGGAATTGTGGCAGGATCATCCTGC
AGTCTCCCAATGGACGTTTCCTGGGCATCGTAGCTAATGGTCTGCTGATGGCCAATGCCACCAT
TCCAGGCCCAAATGAGGAATTTGGGATCCGATTAGCCAACCGTCCCTTTCTCGCCTTGCGGGGC
CGGTATGGCTATGTGGGCACCTCCTCCGAACATGACCTCCTGCAGTGCAATATGGATCAGCCCG
ACTGCATTCACCTGCTGCCCTGCCGCCAGGGCATCTACCACTTCCAGGCACAGGGAGGATCCTT
CTGGTCAATAACATCCTTTGGGACCTTTCGCCCTTGGGGAAAGTTCGCCCTCAACTTCTGTATA
GAGCTTCAGGGCAGCAACTTGCTCACGGTGCTGGCACCCAATGGCTTCTACATGCGGTCCGACC
GAAGTGGCACCCTGTTGGCAGACAGCGAAGACATTACCAAAGAGTGTATTTGGGAATTTTAGGT
CCTTGGGATGTCACCTACGGAAATCCAGATTCTCCAGGAGAAAGTACTGCAGTAAACCCAGCAG
GAGGCCCAGAGTCAGGATCCATGAGAAGAATATCTGTTACTCAACTTTTCCTACCCAGTTTAGC
AAAACACCTGTTTCGAGCAACAATACATCACAAAAGGCCACCCCAAAAAAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001038012	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABC54733	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001038012 ⟸ NM_001044547

- UniProtKB:

Q2I373 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDEAEWTPRPARAEDLRVGLISWAGSYLTFETYKNTVTATAKGLGRRQTWEILVSNEHDAQAMV
RLRSLQGLYLLCEADGSLCYGRPRTSHHGCFLLRFHRNGKWTLQCIISGRYLESDGEDVFCTSR
VLSAYHMWTPRPALHVHVILYSPLNRCYARADPTMGRVWVDAPVPCLEECGFLLHFQDGCYHLE
TSAHTFLSHLDRLVSQPSTQTAFHMQVRPGGLVALSDGEGGTLYPQGTRLLLGLGSSPCGGEEW
FILQRCPTWVSLRSKTRKFLSIVYDVEVCAASEHITPMSLFQFECNNESPNVQLRSSNGCYLVQ
RRHRTVMADGHPLESDTFFRMHWNCGRIILQSPNGRFLGIVANGLLMANATIPGPNEEFGIRLA
NRPFLALRGRYGYVGTSSEHDLLQCNMDQPDCIHLLPCRQGIYHFQAQGGSFWSITSFGTFRPW
GKFALNFCIELQGSNLLTVLAPNGFYMRSDRSGTLLADSEDITKECIWEF

hide sequence

RefSeq Acc Id:

ENSSSCP00000017576 ⟸ ENSSSCT00000018064

Protein Domains

Fascin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000016592	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070028240	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000017576	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00070048118	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000018064	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00070056635	UniProtKB/TrEMBL
InterPro	Actin-crosslinking	UniProtKB/TrEMBL
	Fascin	UniProtKB/TrEMBL
	Fascin-domain	UniProtKB/TrEMBL
	Fascin_metazoans	UniProtKB/TrEMBL
	FSCN3	UniProtKB/TrEMBL
KEGG Report	ssc:733598	UniProtKB/TrEMBL
NCBI Gene	FSCN3	ENTREZGENE
PANTHER	PTHR10551	UniProtKB/TrEMBL
	PTHR10551:SF1	UniProtKB/TrEMBL
Pfam	Fascin	UniProtKB/TrEMBL
PIRSF	Fascin	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50405	UniProtKB/TrEMBL
UniProt	A0A4X1VWI1_PIG	UniProtKB/TrEMBL
	Q2I373	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1SML2	UniProtKB/TrEMBL
VGNC ID	VGNC:88250	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar