PNPLA2 (patatin like phospholipase domain containing 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PNPLA2 (patatin like phospholipase domain containing 2) Sus scrofa
Analyze
Symbol: PNPLA2
Name: patatin like phospholipase domain containing 2
RGD ID: 14202369
Description: ENCODES a protein that exhibits retinyl-palmitate esterase activity (ortholog); INVOLVED IN cellular lipid catabolic process (ortholog); lipid droplet organization (ortholog); triglyceride catabolic process (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); genetic disease (ortholog); FOUND IN lipid droplet (ortholog); INTERACTS WITH monosodium L-glutamate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adipose triglyceride lipase; ATGL; patatin-like phospholipase domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2513,076 - 518,187 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12513,065 - 517,962 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,833 - 161,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA)
lipid droplet  (IBA,ISO)
membrane  (IBA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:16484798   PMID:18189154   PMID:18407985   PMID:19626423   PMID:20480242   PMID:23296834   PMID:27565982  


Genomics

Comparative Map Data
PNPLA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2513,076 - 518,187 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12513,065 - 517,962 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,833 - 161,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11818,914 - 825,573 (+)EnsemblGRCh38hg38GRCh38
GRCh3811818,914 - 825,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711818,914 - 825,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611808,902 - 815,217 (+)NCBINCBI36hg18NCBI36
Build 3411808,901 - 815,216NCBI
Celera11885,450 - 892,225 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11634,726 - 640,840 (+)NCBIHuRef
CHM1_111817,799 - 824,534 (+)NCBICHM1_1
Pnpla2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,035,101 - 141,040,656 (+)NCBIGRCm39mm39
GRCm39 Ensembl7141,035,111 - 141,040,656 (+)Ensembl
GRCm387141,455,188 - 141,460,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,455,198 - 141,460,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,641,087 - 148,646,642 (+)NCBIGRCm37mm9NCBIm37
MGSCv367141,306,527 - 141,311,414 (+)NCBImm8
Celera7141,248,977 - 141,254,535 (+)NCBICelera
Cytogenetic Map7F5NCBI
Pnpla2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21196,552,723 - 196,557,805 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1196,552,723 - 196,557,805 (+)Ensembl
Rnor_6.01214,434,638 - 214,439,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,434,626 - 214,439,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,997,709 - 214,002,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,914,961 - 220,920,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,641,939 - 201,647,021 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1194,186,305 - 194,191,301 (+)NCBICelera
Cytogenetic Map1q41NCBI
Pnpla2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,303,843 - 11,309,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,304,660 - 11,309,755 (-)NCBIChiLan1.0ChiLan1.0
PNPLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111883,279 - 887,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11881,934 - 886,896 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011838,339 - 844,035 (+)NCBIMhudiblu_PPA_v0panPan3
PNPLA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,182,569 - 45,187,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,182,566 - 45,187,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,849,713 - 43,854,935 (+)NCBI
ROS_Cfam_1.01845,847,672 - 45,852,617 (+)NCBI
UMICH_Zoey_3.11845,312,419 - 45,317,644 (+)NCBI
UNSW_CanFamBas_1.01844,877,261 - 44,882,484 (+)NCBI
UU_Cfam_GSD_1.01845,615,387 - 45,620,610 (+)NCBI
Pnpla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947580,773 - 585,949 (+)NCBI
SpeTri2.0NW_004936888580,773 - 585,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11626,060 - 631,556 (+)NCBI
Vero_WHO_p1.0NW_02366603897,715,973 - 97,721,418 (+)NCBI
Pnpla2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,692,023 - 21,697,018 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 2
Low 10 3 3 5 22 2 3 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014036   ⟹   ENSSSCP00000013651
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2513,076 - 518,187 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081736   ⟹   ENSSSCP00000061348
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2513,076 - 518,187 (+)Ensembl
RefSeq Acc Id: NM_001098605   ⟹   NP_001092075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12513,237 - 517,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076533   ⟹   XP_020932192
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12513,065 - 517,962 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001304228
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12513,065 - 517,962 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020932192   ⟸   XM_021076533
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001092075   ⟸   NM_001098605
- UniProtKB: A5JT14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000061348   ⟸   ENSSSCT00000081736
RefSeq Acc Id: ENSSSCP00000013651   ⟸   ENSSSCT00000014036
Protein Domains
PNPLA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013651 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061348 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014036 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000081736 ENTREZGENE, UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  PLPL UniProtKB/TrEMBL
  PNPLA2 UniProtKB/TrEMBL
  PNPLA_dom UniProtKB/TrEMBL
KEGG Report ssc:100049704 UniProtKB/TrEMBL
NCBI Gene PNPLA2 ENTREZGENE
PANTHER PTHR12406 UniProtKB/TrEMBL
Pfam Patatin UniProtKB/TrEMBL
PROSITE PNPLA UniProtKB/TrEMBL
Superfamily-SCOP SSF52151 UniProtKB/TrEMBL
UniProt A0A5G2QH60_PIG UniProtKB/TrEMBL
  A5JT14 ENTREZGENE, UniProtKB/TrEMBL
  A5JT15_PIG UniProtKB/TrEMBL
  B3SPX0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91607 ENTREZGENE