FGF10 (fibroblast growth factor 10) - Rat Genome Database

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Gene: FGF10 (fibroblast growth factor 10) Sus scrofa
Analyze
Symbol: FGF10
Name: fibroblast growth factor 10
RGD ID: 14199577
Description: ENCODES a protein that exhibits chemoattractant activity (inferred); fibroblast growth factor receptor binding (inferred); growth factor activity (inferred); INVOLVED IN angiogenesis (ortholog); animal organ formation (ortholog); animal organ morphogenesis (ortholog); ASSOCIATED WITH Acute Otitis Media (ortholog); aplasia of lacrimal and salivary glands (ortholog); Breast Neoplasms (ortholog); FOUND IN cell surface (inferred); collagen-containing extracellular matrix (inferred); extracellular space (inferred); INTERACTS WITH chondroitin sulfate; dermatan sulfate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: obg-like ATPase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,695,470 - 28,777,509 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11628,695,465 - 28,779,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,234,658 - 30,317,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
angiogenesis  (ISO)
animal organ formation  (IEA,ISO)
animal organ morphogenesis  (IBA,IEA,ISO)
blood vessel morphogenesis  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
branch elongation involved in salivary gland morphogenesis  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
branching morphogenesis of an epithelial tube  (IEA)
bronchiole morphogenesis  (IEA,ISO)
bud elongation involved in lung branching  (IEA,ISO)
bud outgrowth involved in lung branching  (IEA,ISO)
cell differentiation  (IBA,ISO)
cell population proliferation  (IEA,ISO)
cell-cell signaling  (IEA,ISO)
chemotaxis  (IEA,ISO)
determination of left/right symmetry  (IEA,ISO)
digestive tract development  (IEA,ISO)
embryonic camera-type eye development  (IEA,ISO)
embryonic digestive tract development  (IEA,ISO)
embryonic digestive tract morphogenesis  (IEA,ISO)
embryonic genitalia morphogenesis  (IEA,ISO)
embryonic pattern specification  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
epidermis development  (IEA,ISO)
epidermis morphogenesis  (IEA,ISO)
epithelial cell differentiation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of mitotic spindle orientation  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
female genitalia morphogenesis  (IEA,ISO)
fibroblast growth factor receptor apoptotic signaling pathway  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,ISO)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
Harderian gland development  (IEA,ISO)
induction of positive chemotaxis  (IEA,ISO)
inner ear morphogenesis  (IEA,ISO)
keratinocyte proliferation  (IEA,ISO)
lacrimal gland development  (IEA,ISO)
limb bud formation  (IEA,ISO)
limb development  (IEA,ISO)
limb morphogenesis  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (IEA,ISO)
lung epithelium development  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
lung proximal/distal axis specification  (IEA,ISO)
lung saccule development  (IEA)
male genitalia morphogenesis  (IEA,ISO)
mammary gland bud formation  (IEA,ISO)
mammary gland specification  (IEA,ISO)
mesenchymal cell differentiation involved in lung development  (IEA,ISO)
mesenchymal-epithelial cell signaling involved in lung development  (IEA,ISO)
mesonephros development  (IEA)
metanephros development  (IEA)
metanephros morphogenesis  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
muscle cell fate commitment  (IEA,ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
negative regulation of stem cell proliferation  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
organ growth  (IEA,ISO)
organ induction  (IEA,ISO)
otic vesicle formation  (IEA,ISO)
pancreas development  (IEA,ISO)
pituitary gland development  (IEA,ISO)
positive chemotaxis  (IBA,IEA,ISO)
positive regulation of ATP-dependent activity  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (IBA)
positive regulation of DNA repair  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of epithelial cell migration  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IEA)
positive regulation of gene expression  (IBA)
positive regulation of hair follicle cell proliferation  (IEA)
positive regulation of keratinocyte migration  (IEA)
positive regulation of keratinocyte proliferation  (IEA,ISO)
positive regulation of lymphocyte proliferation  (IEA)
positive regulation of MAPK cascade  (IBA,IEA)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of Ras protein signal transduction  (IEA)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of urothelial cell proliferation  (IEA,ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of white fat cell proliferation  (IEA,ISO)
positive regulation of Wnt signaling pathway  (IEA,ISO)
prostatic bud formation  (IEA,ISO)
protein localization to cell surface  (IEA)
radial glial cell differentiation  (IEA)
regulation of activin receptor signaling pathway  (IEA,ISO)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IEA,ISO)
regulation of cell migration  (IBA)
regulation of gene expression  (IEA,ISO)
regulation of saliva secretion  (IEA)
regulation of smoothened signaling pathway  (IEA,ISO)
respiratory system development  (IEA,ISO)
response to estradiol  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
salivary gland development  (IEA)
salivary gland morphogenesis  (IEA,ISO)
secretion by lung epithelial cell involved in lung growth  (IEA)
semicircular canal fusion  (IEA,ISO)
semicircular canal morphogenesis  (IEA,ISO)
signal transduction  (IEA)
smooth muscle cell differentiation  (IEA,ISO)
somatic stem cell population maintenance  (IEA,ISO)
spleen development  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
submandibular salivary gland formation  (IEA,ISO)
tear secretion  (IEA)
thymus development  (IEA)
thyroid gland development  (IEA,ISO)
tissue regeneration  (ISO)
type II pneumocyte differentiation  (IEA,ISO)
urothelial cell proliferation  (IEA)
vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
white fat cell differentiation  (IEA,ISO)
white fat cell proliferation  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)
wound healing  (IBA,IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,695,470 - 28,777,509 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11628,695,465 - 28,779,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,234,658 - 30,317,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38544,300,247 - 44,389,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl544,300,247 - 44,389,706 (-)EnsemblGRCh38hg38GRCh38
GRCh37544,300,349 - 44,389,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36544,340,854 - 44,424,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 34544,340,853 - 44,424,541NCBI
Celera544,197,375 - 44,281,044 (-)NCBICelera
Cytogenetic Map5p12NCBI
HuRef544,258,055 - 44,341,703 (-)NCBIHuRef
CHM1_1544,306,497 - 44,390,196 (-)NCBICHM1_1
T2T-CHM13v2.0544,553,832 - 44,642,982 (-)NCBIT2T-CHM13v2.0
Fgf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913118,851,199 - 118,928,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13118,806,327 - 118,928,651 (+)EnsemblGRCm39 Ensembl
GRCm3813118,714,699 - 118,792,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13118,669,791 - 118,792,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713119,503,506 - 119,581,380 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613119,833,907 - 119,910,988 (+)NCBIMGSCv36mm8
Celera13123,161,950 - 123,245,519 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.14NCBI
Fgf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8252,533,939 - 52,610,980 (+)NCBIGRCr8
mRatBN7.2250,801,171 - 50,878,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl250,800,992 - 50,876,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx257,899,752 - 57,973,217 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0255,958,474 - 56,031,945 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0250,887,932 - 50,961,398 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0251,673,480 - 51,747,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl251,672,722 - 51,750,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0270,046,331 - 70,120,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4250,866,799 - 50,940,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1250,795,031 - 50,868,552 (+)NCBI
Celera246,463,913 - 46,537,376 (+)NCBICelera
Cytogenetic Map2q14NCBI
Fgf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,163,117 - 18,245,199 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544618,163,117 - 18,244,840 (+)NCBIChiLan1.0ChiLan1.0
FGF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2465,933,753 - 66,021,682 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1564,085,283 - 64,175,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0565,979,443 - 66,069,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1571,028,324 - 71,111,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl571,028,187 - 71,111,706 (+)Ensemblpanpan1.1panPan2
FGF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1465,851,130 - 65,930,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl465,851,069 - 65,928,192 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha465,597,673 - 65,676,839 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0466,343,407 - 66,423,104 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl466,343,839 - 66,423,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,096,317 - 66,176,025 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0466,218,509 - 66,297,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0466,768,760 - 66,848,396 (+)NCBIUU_Cfam_GSD_1.0
Fgf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,177,124 - 209,259,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,114,204 - 18,195,898 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,114,231 - 18,195,884 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1443,080,387 - 43,163,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl443,081,831 - 43,163,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607133,710,353 - 33,794,576 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475910,904,989 - 10,983,574 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475910,904,626 - 10,983,509 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF10
1126 total Variants

Sequence


Ensembl Acc Id: ENSSSCT00000018382   ⟹   ENSSSCP00000017886
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1628,695,470 - 28,777,509 (-)Ensembl
RefSeq Acc Id: XM_021077140   ⟹   XP_020932799
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11628,695,465 - 28,779,953 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020932799   ⟸   XM_021077140
- UniProtKB: A0A4X1SSI8 (UniProtKB/TrEMBL),   F1SMG2 (UniProtKB/TrEMBL),   A0A8D0XPM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000017886   ⟸   ENSSSCT00000018382


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016878 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005017856 UniProtKB/TrEMBL
  ENSSSCG00015023938 UniProtKB/TrEMBL
  ENSSSCG00025046747 UniProtKB/TrEMBL
  ENSSSCG00030061384 UniProtKB/TrEMBL
  ENSSSCG00035066777 UniProtKB/TrEMBL
  ENSSSCG00040045580 UniProtKB/TrEMBL
  ENSSSCG00045011050 UniProtKB/TrEMBL
  ENSSSCG00050021855 UniProtKB/TrEMBL
  ENSSSCG00055016306 UniProtKB/TrEMBL
  ENSSSCG00060036763 UniProtKB/TrEMBL
  ENSSSCG00065028796 UniProtKB/TrEMBL
  ENSSSCG00070003365 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018382 ENTREZGENE
  ENSSSCT00000018382.5 UniProtKB/TrEMBL
  ENSSSCT00005028207.1 UniProtKB/TrEMBL
  ENSSSCT00015031768.1 UniProtKB/TrEMBL
  ENSSSCT00025063560.1 UniProtKB/TrEMBL
  ENSSSCT00030085823.1 UniProtKB/TrEMBL
  ENSSSCT00035090012.1 UniProtKB/TrEMBL
  ENSSSCT00040061216.1 UniProtKB/TrEMBL
  ENSSSCT00045018772.1 UniProtKB/TrEMBL
  ENSSSCT00050029460.1 UniProtKB/TrEMBL
  ENSSSCT00055032155.1 UniProtKB/TrEMBL
  ENSSSCT00060049811.1 UniProtKB/TrEMBL
  ENSSSCT00065038845.1 UniProtKB/TrEMBL
  ENSSSCT00070006344.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene FGF10 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF21 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/TrEMBL
  IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A4X1SSI8 ENTREZGENE
  A0A8D0XPM7 ENTREZGENE, UniProtKB/TrEMBL
  F1SMG2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1SSI8 UniProtKB/TrEMBL
VGNC ID VGNC:88101 ENTREZGENE