NPC2 (NPC intracellular cholesterol transporter 2) - Rat Genome Database
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Gene: NPC2 (NPC intracellular cholesterol transporter 2) Sus scrofa
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Symbol: NPC2
Name: NPC intracellular cholesterol transporter 2
RGD ID: 14198595
Description: ENCODES a protein that exhibits cholesterol binding; cholesterol transfer activity (ortholog); enzyme binding (ortholog); INVOLVED IN cholesterol efflux (ortholog); cholesterol homeostasis (ortholog); cholesterol transport (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); intellectual disability (ortholog); Niemann-Pick disease (ortholog); FOUND IN extracellular space; lysosome (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 16 kDa secretory protein; 16kDa secretory protein; epididymal secretory protein E1; niemann Pick type C2 protein homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,730,514 - 97,740,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,730,532 - 97,740,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,573,100 - 103,582,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:10366780   PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
NPC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,730,514 - 97,740,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,730,532 - 97,740,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,573,100 - 103,582,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1474,476,192 - 74,494,177 (-)EnsemblGRCh38hg38GRCh38
GRCh381474,479,935 - 74,493,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371474,946,638 - 74,960,215 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371474,942,900 - 74,960,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,016,396 - 74,029,837 (-)NCBINCBI36hg18NCBI36
Build 341474,016,396 - 74,029,837NCBI
Celera1454,985,030 - 54,998,469 (-)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1455,115,095 - 55,128,528 (-)NCBIHuRef
CHM1_11474,886,183 - 74,899,622 (-)NCBICHM1_1
Npc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,801,333 - 84,819,886 (-)NCBIGRCm39mm39
GRCm381284,754,559 - 84,773,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,754,562 - 84,773,152 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,095,509 - 86,114,062 (-)NCBIGRCm37mm9NCBIm37
MGSCv361285,644,307 - 85,662,860 (-)NCBImm8
Celera1286,210,583 - 86,229,366 (-)NCBICelera
Cytogenetic Map12D1NCBI
Npc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26104,397,239 - 104,418,161 (-)NCBI
Rnor_6.0 Ensembl6108,467,410 - 108,488,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06108,467,410 - 108,488,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06117,060,860 - 117,081,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,793,935 - 108,814,703 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16108,797,391 - 108,818,159 (-)NCBI
Celera6102,222,115 - 102,243,035 (-)NCBICelera
Cytogenetic Map6q31NCBI
Npc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,010,976 - 1,021,144 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBIChiLan1.0ChiLan1.0
NPC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11473,875,856 - 73,894,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,875,889 - 73,894,628 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01455,033,129 - 55,046,564 (-)NCBIMhudiblu_PPA_v0panPan3
NPC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl847,628,077 - 47,650,576 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1847,641,185 - 47,650,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Npc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364883,664,171 - 3,676,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,685,699 - 51,700,557 (-)NCBI
ChlSab1.1 Ensembl2451,685,609 - 51,700,557 (-)Ensembl
Npc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473427,166,867 - 27,177,229 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High 1
Medium 10 4 3 5 2 22 2 2 3
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002630   ⟹   ENSSSCP00000002564
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl797,730,514 - 97,740,331 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000079038   ⟹   ENSSSCP00000073764
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl797,730,514 - 97,736,653 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086332   ⟹   ENSSSCP00000060807
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl797,730,838 - 97,740,331 (-)Ensembl
RefSeq Acc Id: NM_214206   ⟹   NP_999371
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1797,730,532 - 97,740,087 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999371 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD00096 (Get FASTA)   NCBI Sequence Viewer  
  BAI78329 (Get FASTA)   NCBI Sequence Viewer  
  O97763 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999371   ⟸   NM_214206
- Peptide Label: precursor
- UniProtKB: O97763 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002564   ⟸   ENSSSCT00000002630
RefSeq Acc Id: ENSSSCP00000073764   ⟸   ENSSSCT00000079038
RefSeq Acc Id: ENSSSCP00000060807   ⟸   ENSSSCT00000086332
Protein Domains
ML


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002366 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005040002 UniProtKB/Swiss-Prot
  ENSSSCG00015079034 UniProtKB/Swiss-Prot
  ENSSSCG00025011176 UniProtKB/Swiss-Prot
  ENSSSCG00030031683 UniProtKB/Swiss-Prot
  ENSSSCG00035011913 UniProtKB/Swiss-Prot
  ENSSSCG00040057371 UniProtKB/Swiss-Prot
  ENSSSCG00045034006 UniProtKB/Swiss-Prot
  ENSSSCG00050069000 UniProtKB/Swiss-Prot
  ENSSSCG00055000690 UniProtKB/Swiss-Prot
  ENSSSCG00060007744 UniProtKB/Swiss-Prot
  ENSSSCG00065024849 UniProtKB/Swiss-Prot
  ENSSSCG00070009444 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002564 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000060807 UniProtKB/TrEMBL
  ENSSSCP00000073764 UniProtKB/TrEMBL
  ENSSSCP00005039655 UniProtKB/Swiss-Prot
  ENSSSCP00015045201 UniProtKB/Swiss-Prot
  ENSSSCP00025006069 UniProtKB/Swiss-Prot
  ENSSSCP00030019816 UniProtKB/Swiss-Prot
  ENSSSCP00035005118 UniProtKB/Swiss-Prot
  ENSSSCP00040034313 UniProtKB/Swiss-Prot
  ENSSSCP00045040685 UniProtKB/Swiss-Prot
  ENSSSCP00050040623 UniProtKB/Swiss-Prot
  ENSSSCP00055000871 UniProtKB/Swiss-Prot
  ENSSSCP00060003610 UniProtKB/Swiss-Prot
  ENSSSCP00065013770 UniProtKB/Swiss-Prot
  ENSSSCP00070015212 UniProtKB/Swiss-Prot
  ENSSSCP00070015217 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002630 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000079038 UniProtKB/TrEMBL
  ENSSSCT00000086332 UniProtKB/TrEMBL
  ENSSSCT00005064187 UniProtKB/Swiss-Prot
  ENSSSCT00015107137 UniProtKB/Swiss-Prot
  ENSSSCT00025015410 UniProtKB/Swiss-Prot
  ENSSSCT00030043905 UniProtKB/Swiss-Prot
  ENSSSCT00035014997 UniProtKB/Swiss-Prot
  ENSSSCT00040079466 UniProtKB/Swiss-Prot
  ENSSSCT00045058199 UniProtKB/Swiss-Prot
  ENSSSCT00050094206 UniProtKB/Swiss-Prot
  ENSSSCT00055001194 UniProtKB/Swiss-Prot
  ENSSSCT00060009877 UniProtKB/Swiss-Prot
  ENSSSCT00065033318 UniProtKB/Swiss-Prot
  ENSSSCT00070018316 UniProtKB/Swiss-Prot
  ENSSSCT00070018321 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ML_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ML_Npc2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPC2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397410 UniProtKB/Swiss-Prot
NCBI Gene NPC2 ENTREZGENE
PANTHER PTHR11306 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1_DerP2_DerF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1TFG8_PIG UniProtKB/TrEMBL
  A0A5G2Q956_PIG UniProtKB/TrEMBL
  A0A5G2RMF7_PIG UniProtKB/TrEMBL
  NPC2_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:90843 ENTREZGENE