WNK3 (WNK lysine deficient protein kinase 3) - Rat Genome Database

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Gene: WNK3 (WNK lysine deficient protein kinase 3) Sus scrofa
Analyze
Symbol: WNK3
Name: WNK lysine deficient protein kinase 3
RGD ID: 14197646
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN cell volume homeostasis (ortholog); maintenance of blood-brain barrier (ortholog); negative regulation of pancreatic juice secretion (ortholog); ASSOCIATED WITH autistic disorder (ortholog); syndromic X-linked intellectual disability Lubs type (ortholog); FOUND IN adherens junction (ortholog); bicellular tight junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine/threonine-protein kinase WNK3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,920,350 - 47,096,022 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,923,587 - 47,096,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X52,773,667 - 52,939,547 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
WNK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,920,350 - 47,096,022 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,923,587 - 47,096,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X52,773,667 - 52,939,547 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX54,192,823 - 54,358,642 (-)EnsemblGRCh38hg38GRCh38
GRCh38X54,192,823 - 54,358,695 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X54,219,256 - 54,384,479 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,239,580 - 54,401,163 (-)NCBINCBI36hg18NCBI36
Build 34X54,105,875 - 54,267,459NCBI
CeleraX58,050,484 - 58,215,673 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX51,270,978 - 51,435,935 (-)NCBIHuRef
CHM1_1X54,209,950 - 54,375,102 (-)NCBICHM1_1
Wnk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X149,951,774 - 150,103,190 (+)NCBIGRCm39mm39
GRCm39 EnsemblX149,981,074 - 150,103,148 (+)Ensembl
GRCm38X151,168,777 - 151,320,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX151,198,078 - 151,320,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X147,632,683 - 147,754,695 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X146,538,856 - 146,660,908 (+)NCBImm8
CeleraX133,089,421 - 133,204,703 (-)NCBICelera
Cytogenetic MapXF3NCBI
Wnk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X20,156,260 - 20,299,252 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX20,157,041 - 20,296,821 (+)Ensembl
Rnor_6.0X20,316,081 - 20,459,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX20,316,893 - 20,454,357 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,060,886 - 21,204,035 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X40,531,972 - 40,635,583 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX20,447,903 - 20,550,458 (+)NCBICelera
Cytogenetic MapXq12NCBI
Wnk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554751,446,498 - 1,642,061 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554751,441,068 - 1,641,599 (-)NCBIChiLan1.0ChiLan1.0
WNK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X54,629,583 - 54,789,185 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX54,629,583 - 54,789,185 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X46,391,870 - 46,555,232 (-)NCBIMhudiblu_PPA_v0panPan3
WNK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,951,049 - 46,111,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,571,840 - 46,081,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX37,410,899 - 37,499,944 (-)NCBI
ROS_Cfam_1.0X46,278,707 - 46,332,213 (-)NCBI
UMICH_Zoey_3.1X45,770,039 - 45,930,806 (-)NCBI
UNSW_CanFamBas_1.0X46,220,590 - 46,381,230 (-)NCBI
UU_Cfam_GSD_1.0X46,287,717 - 46,448,493 (-)NCBI
Wnk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X38,755,261 - 38,927,032 (-)NCBI
SpeTri2.0NW_0049367511,095,578 - 1,266,772 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X50,320,585 - 50,452,911 (-)NCBI
ChlSab1.1 EnsemblX50,320,674 - 50,452,943 (-)Ensembl
Vero_WHO_p1.0NW_0236660864,266,929 - 4,437,306 (-)NCBI
Wnk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249091,886,372 - 2,107,582 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1
Low 1 2 2 4 22 2 3 1
Below cutoff 9 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013486   ⟹   ENSSSCP00000013125
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX46,930,990 - 47,095,833 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000034044   ⟹   ENSSSCP00000028718
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX46,920,350 - 47,096,022 (-)Ensembl
RefSeq Acc Id: XM_003360334   ⟹   XP_003360382
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X46,923,587 - 47,095,361 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013986186   ⟹   XP_013841640
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X46,923,587 - 47,095,362 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013986187   ⟹   XP_013841641
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X46,923,587 - 47,095,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013986188   ⟹   XP_013841642
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X46,923,587 - 47,096,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013986189   ⟹   XP_013841643
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X46,923,587 - 47,096,265 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079752   ⟹   XP_020935411
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X46,923,587 - 47,095,848 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013841643   ⟸   XM_013986189
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013841642   ⟸   XM_013986188
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013841641   ⟸   XM_013986187
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020935411   ⟸   XM_021079752
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013841640   ⟸   XM_013986186
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003360382   ⟸   XM_003360334
- Peptide Label: isoform X2
- UniProtKB: F1RUG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000028718   ⟸   ENSSSCT00000034044
RefSeq Acc Id: ENSSSCP00000013125   ⟸   ENSSSCT00000013486
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012332 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013125 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000028718 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013486 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000034044 ENTREZGENE, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100156408 UniProtKB/TrEMBL
NCBI Gene WNK3 ENTREZGENE
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A480ESI3_PIG UniProtKB/TrEMBL
  A0A5K1VQ40_PIG UniProtKB/TrEMBL
  F1RUG5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary K7GLI8 UniProtKB/TrEMBL
VGNC ID VGNC:94964 ENTREZGENE