HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1) - Rat Genome Database

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Gene: HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1) Sus scrofa
Analyze
Symbol: HCN1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
RGD ID: 14192700
Description: ENCODES a protein that exhibits identical protein binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN aging (ortholog); apical protein localization (ortholog); cellular response to interferon-beta (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); anxiety disorder (ortholog); Ataxia (ortholog); FOUND IN apical dendrite (ortholog); axon (ortholog); axon terminus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1629,439,263 - 29,809,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11629,439,294 - 29,808,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,946,691 - 31,323,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
HCN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1629,439,263 - 29,809,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11629,439,294 - 29,808,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,946,691 - 31,323,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HCN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl545,254,948 - 45,696,498 (-)EnsemblGRCh38hg38GRCh38
GRCh38545,254,948 - 45,696,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37545,255,050 - 45,696,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36545,295,109 - 45,731,977 (-)NCBINCBI36hg18NCBI36
Build 34545,297,729 - 45,731,977NCBI
Celera545,153,108 - 45,590,074 (-)NCBI
Cytogenetic Map5p12NCBI
HuRef545,207,222 - 45,649,517 (-)NCBIHuRef
CHM1_1545,254,898 - 45,696,071 (-)NCBICHM1_1
Hcn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913117,738,856 - 118,117,564 (+)NCBIGRCm39mm39
GRCm39 Ensembl13117,738,856 - 118,123,954 (+)Ensembl
GRCm3813117,602,320 - 117,981,028 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13117,602,320 - 117,987,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713118,391,127 - 118,769,835 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613118,721,981 - 119,096,083 (+)NCBImm8
Celera13122,021,998 - 122,417,756 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1366.34NCBI
Hcn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2249,495,771 - 49,899,702 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl249,495,771 - 49,899,774 (+)Ensembl
Rnor_6.0250,099,576 - 50,499,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl250,099,576 - 50,499,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0268,473,431 - 68,874,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4249,525,949 - 49,939,066 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1249,454,181 - 49,867,299 (+)NCBI
Celera245,196,523 - 45,593,603 (+)NCBICelera
Cytogenetic Map2q15NCBI
Hcn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544617,151,311 - 17,457,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544617,146,915 - 17,457,843 (+)NCBIChiLan1.0ChiLan1.0
HCN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1569,724,749 - 70,161,427 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl569,724,767 - 70,158,761 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0564,673,392 - 65,116,259 (+)NCBIMhudiblu_PPA_v0panPan3
HCN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1464,777,069 - 65,162,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl464,775,577 - 65,160,444 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha464,536,272 - 64,921,927 (+)NCBI
ROS_Cfam_1.0465,274,982 - 65,661,386 (+)NCBI
UMICH_Zoey_3.1465,037,683 - 65,423,922 (+)NCBI
UNSW_CanFamBas_1.0465,160,205 - 65,546,474 (+)NCBI
UU_Cfam_GSD_1.0465,696,155 - 66,082,848 (+)NCBI
Hcn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213208,115,409 - 208,479,849 (+)NCBI
SpeTri2.0NW_00493648017,051,902 - 17,416,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1444,029,173 - 44,443,669 (-)NCBI
Vero_WHO_p1.0NW_02366607134,696,131 - 35,142,081 (-)NCBI
Hcn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247599,636,380 - 10,044,832 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system musculoskeletal system nervous system
High
Medium 8
Low 3 2 15
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000028722   ⟹   ENSSSCP00000022511
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1629,439,263 - 29,809,748 (-)Ensembl
RefSeq Acc Id: XM_021077110   ⟹   XP_020932769
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11629,439,294 - 29,808,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021077111   ⟹   XP_020932770
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11629,439,294 - 29,769,731 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020932769 (Get FASTA)   NCBI Sequence Viewer  
  XP_020932770 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020932769   ⟸   XM_021077110
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020932770   ⟸   XM_021077111
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000022511   ⟸   ENSSSCT00000028722
Protein Domains
Cyclic nucleotide-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000022511 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028722 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/TrEMBL
  K/Na_HCN1 UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene HCN1 ENTREZGENE
PANTHER PTHR45689:SF3 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/TrEMBL
PRINTS EAGCHANLFMLY UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
UniProt I3LEM3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88802 ENTREZGENE