TOP1MT (DNA topoisomerase I mitochondrial) - Rat Genome Database

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Gene: TOP1MT (DNA topoisomerase I mitochondrial) Sus scrofa
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Symbol: TOP1MT
Name: DNA topoisomerase I mitochondrial
RGD ID: 14187601
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA topoisomerase activity (inferred); DNA topoisomerase type I (single strand cut, ATP-independent) activity (inferred); INVOLVED IN DNA topological change (inferred); ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); holoprosencephaly (ortholog); FOUND IN chromosome (inferred); mitochondrial nucleoid (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA topoisomerase I, mitochondrial; topoisomerase (DNA) I, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl41,148,890 - 1,188,130 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.141,134,179 - 1,188,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.241,068,174 - 1,125,241 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TOP1MT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl41,148,890 - 1,188,130 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.141,134,179 - 1,188,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.241,068,174 - 1,125,241 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOP1MT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,309,324 - 143,359,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,304,384 - 143,359,979 (-)EnsemblGRCh38hg38GRCh38
GRCh378144,391,494 - 144,442,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,462,901 - 144,488,425 (-)NCBINCBI36Build 36hg18NCBI36
Build 348144,462,904 - 144,488,425NCBI
Celera8140,700,651 - 140,727,260 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,629,915 - 139,695,642 (-)NCBIHuRef
CHM1_18144,431,738 - 144,482,220 (-)NCBICHM1_1
T2T-CHM13v2.08144,456,634 - 144,507,610 (-)NCBIT2T-CHM13v2.0
Top1mt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,528,878 - 75,551,184 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,528,884 - 75,550,649 (-)EnsemblGRCm39 Ensembl
GRCm381575,657,033 - 75,678,800 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,657,035 - 75,678,800 (-)EnsemblGRCm38mm10GRCm38
MGSCv371575,487,463 - 75,509,220 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361575,484,288 - 75,506,045 (-)NCBIMGSCv36mm8
Celera1577,157,202 - 77,179,081 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.69NCBI
Top1mt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,223,269 - 109,248,855 (-)NCBIGRCr8
mRatBN7.27107,338,092 - 107,368,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,342,527 - 107,366,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,077,854 - 109,100,706 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,301,524 - 111,324,376 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,247,445 - 111,270,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,688,801 - 116,714,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,688,701 - 116,712,387 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,582,993 - 116,608,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,596,083 - 113,619,109 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,630,312 - 113,653,339 (-)NCBI
Celera7103,705,366 - 103,728,376 (-)NCBICelera
Cytogenetic Map7q34NCBI
Top1mt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,021,563 - 2,046,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,020,884 - 2,045,939 (-)NCBIChiLan1.0ChiLan1.0
TOP1MT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,779,424 - 160,836,852 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18136,303,888 - 136,354,388 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08140,056,468 - 140,106,510 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18143,077,224 - 143,125,987 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC103237562
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,523,739 - 137,574,672 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8137,523,955 - 137,552,407 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236670188,188 - 24,004 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top1mt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,417,185 - 13,441,097 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TOP1MT
1393 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 1 5 14 12 23 3 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013993526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002343655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002343656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU655901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP085504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01091197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000007623   ⟹   ENSSSCP00000007420
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl41,148,890 - 1,188,130 (+)Ensembl
RefSeq Acc Id: XM_013993526   ⟹   XP_013848980
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,134,179 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090419   ⟹   XP_020946078
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,148,184 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090420   ⟹   XP_020946079
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,148,184 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090421   ⟹   XP_020946080
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,148,184 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090422   ⟹   XP_020946081
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,148,184 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090423   ⟹   XP_020946082
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,148,184 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090424   ⟹   XP_020946083
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,154,441 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090425   ⟹   XP_020946084
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,155,526 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090426   ⟹   XP_020946085
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,156,079 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090427   ⟹   XP_020946086
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,154,277 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090428   ⟹   XP_020946087
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,148,910 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090429   ⟹   XP_020946088
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,155,525 - 1,188,149 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002343655
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,134,179 - 1,188,087 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002343656
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.141,153,985 - 1,188,137 (+)NCBI
Sequence:
RefSeq Acc Id: XP_013848980   ⟸   XM_013993526
- Peptide Label: isoform X1
- UniProtKB: A0A8D1CNT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946078   ⟸   XM_021090419
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020946079   ⟸   XM_021090420
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020946080   ⟸   XM_021090421
- Peptide Label: isoform X4
- UniProtKB: A0A480YTE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946081   ⟸   XM_021090422
- Peptide Label: isoform X5
- UniProtKB: A0A480YTE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946082   ⟸   XM_021090423
- Peptide Label: isoform X6
- UniProtKB: A0A480YM77 (UniProtKB/TrEMBL),   A0A480YTE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946087   ⟸   XM_021090428
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_020946086   ⟸   XM_021090427
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_020946083   ⟸   XM_021090424
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_020946088   ⟸   XM_021090429
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_020946084   ⟸   XM_021090425
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_020946085   ⟸   XM_021090426
- Peptide Label: isoform X7
- Sequence:
Ensembl Acc Id: ENSSSCP00000007420   ⟸   ENSSSCT00000007623

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006958 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00035018970 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007623 ENTREZGENE
  ENSSSCT00000007623.5 UniProtKB/TrEMBL
  ENSSSCT00035024537.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.41 UniProtKB/TrEMBL
  1.10.132.10 UniProtKB/TrEMBL
  2.170.11.10 UniProtKB/TrEMBL
InterPro DNA_brk_join_enz UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom1 UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom2 UniProtKB/TrEMBL
  TopoI UniProtKB/TrEMBL
  TopoI_AS UniProtKB/TrEMBL
  TopoI_C_dom UniProtKB/TrEMBL
  TopoI_cat_a-hlx-sub_euk UniProtKB/TrEMBL
  TopoI_cat_a/b-sub_euk UniProtKB/TrEMBL
  TopoI_cat_euk UniProtKB/TrEMBL
  TopoI_DNA-bd_euk UniProtKB/TrEMBL
  TopoI_DNA-bd_euk_N_sf UniProtKB/TrEMBL
  TopoI_euk UniProtKB/TrEMBL
  Topoisomer_I_DNA-bd UniProtKB/TrEMBL
  Topoisomerase_IB UniProtKB/TrEMBL
NCBI Gene TOP1MT ENTREZGENE
PANTHER DNA TOPOISOMERASE I UniProtKB/TrEMBL
  DNA TOPOISOMERASE I, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Topo_C_assoc UniProtKB/TrEMBL
  Topoisom_I UniProtKB/TrEMBL
  Topoisom_I_N UniProtKB/TrEMBL
PRINTS EUTPISMRASEI UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_I_EUK UniProtKB/TrEMBL
SMART TOPEUc UniProtKB/TrEMBL
Superfamily-SCOP Eukaryotic DNA topoisomerase I, dispensable insert domain UniProtKB/TrEMBL
  SSF56349 UniProtKB/TrEMBL
  SSF56741 UniProtKB/TrEMBL
UniProt A0A480YM77 ENTREZGENE, UniProtKB/TrEMBL
  A0A480YTE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CNT0 ENTREZGENE, UniProtKB/TrEMBL
  F1SEV4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94309 ENTREZGENE