MRTO4 (MRT4 homolog, ribosome maturation factor) - Rat Genome Database

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Gene: MRTO4 (MRT4 homolog, ribosome maturation factor) Sus scrofa
Analyze
Symbol: MRTO4
Name: MRT4 homolog, ribosome maturation factor
RGD ID: 14185008
Description: ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN nuclear-transcribed mRNA catabolic process (inferred); ribosomal large subunit biogenesis (inferred); ribosome biogenesis (inferred); ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); chromosome 1p36 deletion syndrome (ortholog); congenital disorder of glycosylation Ir (ortholog); FOUND IN cytoplasm (inferred); nucleolus (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mRNA turnover 4 homolog; mRNA turnover protein 4 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl677,747,819 - 77,754,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1677,747,799 - 77,753,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2671,809,896 - 71,816,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MRTO4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl677,747,819 - 77,754,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1677,747,799 - 77,753,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2671,809,896 - 71,816,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRTO4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,251,805 - 19,260,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,251,805 - 19,260,128 (+)EnsemblGRCh38hg38GRCh38
GRCh37119,578,299 - 19,586,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,450,662 - 19,459,209 (+)NCBINCBI36Build 36hg18NCBI36
Build 34119,323,604 - 19,331,064NCBI
Celera117,905,060 - 17,913,606 (+)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef117,824,619 - 17,833,165 (+)NCBIHuRef
CHM1_1119,687,405 - 19,695,952 (+)NCBICHM1_1
T2T-CHM13v2.0119,075,329 - 19,083,650 (+)NCBIT2T-CHM13v2.0
Mrto4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394139,074,751 - 139,079,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4139,074,746 - 139,079,887 (-)EnsemblGRCm39 Ensembl
GRCm384139,347,440 - 139,352,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,347,435 - 139,352,576 (-)EnsemblGRCm38mm10GRCm38
MGSCv374138,903,360 - 138,908,213 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,619,521 - 138,624,374 (-)NCBIMGSCv36mm8
Celera4141,134,667 - 141,139,519 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.65NCBI
Mrto4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,884,985 - 156,891,738 (-)NCBIGRCr8
mRatBN7.25151,601,780 - 151,608,533 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,601,780 - 151,608,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5154,300,433 - 154,307,186 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05156,074,793 - 156,081,547 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05156,055,735 - 156,062,489 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,814,142 - 157,820,889 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,815,361 - 157,820,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,553,854 - 161,560,601 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,149,143 - 158,154,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15158,159,199 - 158,164,409 (-)NCBI
Celera5149,982,626 - 149,988,154 (-)NCBICelera
Cytogenetic Map5q36NCBI
Mrto4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495552712,547 - 18,906 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495552712,547 - 18,906 (-)NCBIChiLan1.0ChiLan1.0
MRTO4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,855,187 - 207,863,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,971,949 - 206,980,338 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,210,403 - 18,218,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,257,147 - 19,265,717 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,257,147 - 19,265,038 (+)Ensemblpanpan1.1panPan2
MRTO4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,360,897 - 79,367,038 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,360,970 - 79,366,935 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,875,788 - 75,881,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,983,604 - 79,989,727 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,983,677 - 79,989,638 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,744,427 - 76,750,539 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,754,345 - 77,760,465 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,825,044 - 78,831,167 (-)NCBIUU_Cfam_GSD_1.0
Mrto4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505839,714,526 - 39,721,298 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364745,539,246 - 5,546,087 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364745,539,306 - 5,546,085 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRTO4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120113,299,433 - 113,306,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20113,299,708 - 113,306,704 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660332,849,826 - 2,857,329 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrto4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247644,400,731 - 4,407,180 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247644,401,005 - 4,406,157 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MRTO4
136 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000059270   ⟹   ENSSSCP00000038369
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl677,747,819 - 77,754,864 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059598   ⟹   ENSSSCP00000031371
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl677,747,826 - 77,753,623 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000060130   ⟹   ENSSSCP00000032410
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl677,747,567 - 77,757,721 (+)Ensembl
RefSeq Acc Id: NM_001243715   ⟹   NP_001230644
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1677,747,799 - 77,753,924 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021093294   ⟹   XP_020948953
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1677,747,821 - 77,753,922 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001230644   ⟸   NM_001243715
- UniProtKB: A0A480VYI2 (UniProtKB/TrEMBL),   A0A8D1HAQ0 (UniProtKB/TrEMBL),   A0A287A384 (UniProtKB/TrEMBL),   A0A4X1W777 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020948953   ⟸   XM_021093294
- Peptide Label: isoform X1
- UniProtKB: A0A8D1C4U6 (UniProtKB/TrEMBL),   A0A8D0PPI6 (UniProtKB/TrEMBL),   A0A8D1SZR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000032410   ⟸   ENSSSCT00000060130
RefSeq Acc Id: ENSSSCP00000038369   ⟸   ENSSSCT00000059270
RefSeq Acc Id: ENSSSCP00000031371   ⟸   ENSSSCT00000059598
Protein Domains
Large ribosomal subunit protein uL10-like insertion


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015063433 UniProtKB/TrEMBL
  ENSSSCG00025063362 UniProtKB/TrEMBL
  ENSSSCG00030028380 UniProtKB/TrEMBL
  ENSSSCG00035073799 UniProtKB/TrEMBL
  ENSSSCG00040066966 UniProtKB/TrEMBL
  ENSSSCG00045011721 UniProtKB/TrEMBL
  ENSSSCG00060010403 UniProtKB/TrEMBL
  ENSSSCG00065045875 UniProtKB/TrEMBL
  ENSSSCG00070029022 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000059270 ENTREZGENE
  ENSSSCT00000059270.2 UniProtKB/TrEMBL
  ENSSSCT00015085007.1 UniProtKB/TrEMBL
  ENSSSCT00025086769.1 UniProtKB/TrEMBL
  ENSSSCT00030039710.1 UniProtKB/TrEMBL
  ENSSSCT00030039725.1 UniProtKB/TrEMBL
  ENSSSCT00035100071.1 UniProtKB/TrEMBL
  ENSSSCT00040091531.1 UniProtKB/TrEMBL
  ENSSSCT00045019912.1 UniProtKB/TrEMBL
  ENSSSCT00045019959.1 UniProtKB/TrEMBL
  ENSSSCT00060013514.1 UniProtKB/TrEMBL
  ENSSSCT00065062768.1 UniProtKB/TrEMBL
  ENSSSCT00065062775.1 UniProtKB/TrEMBL
  ENSSSCT00070058206.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1730 UniProtKB/TrEMBL
  3.90.105.20 UniProtKB/TrEMBL
InterPro Mrt4 UniProtKB/TrEMBL
  Ribosomal_L10-like_sf UniProtKB/TrEMBL
  Ribosomal_L10P UniProtKB/TrEMBL
  RL10_insert_sf UniProtKB/TrEMBL
  RL10P_insert UniProtKB/TrEMBL
KEGG Report ssc:100511136 UniProtKB/TrEMBL
NCBI Gene MRTO4 ENTREZGENE
PANTHER MRNA TURNOVER PROTEIN 4 HOMOLOG UniProtKB/TrEMBL
  MRNA TURNOVER PROTEIN 4 MRTO4 UniProtKB/TrEMBL
Pfam Ribosomal_L10 UniProtKB/TrEMBL
  RL10P_insert UniProtKB/TrEMBL
Superfamily-SCOP SSF160369 UniProtKB/TrEMBL
UniProt A0A287A384 ENTREZGENE, UniProtKB/TrEMBL
  A0A480VYI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W777 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0PPI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1C4U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HAQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1SZR1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90405 ENTREZGENE