GATA2 (GATA binding protein 2) - Rat Genome Database

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Gene: GATA2 (GATA binding protein 2) Sus scrofa
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Symbol: GATA2
Name: GATA binding protein 2
RGD ID: 14183063
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cell differentiation (ortholog); cell differentiation in hindbrain (ortholog); cell fate determination (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); anemia (ortholog); aplastic anemia (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endothelial transcription factor GATA-2; transcription factor GATA-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1371,984,063 - 71,997,622 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11371,981,139 - 71,997,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,606,930 - 79,613,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (ISO)
cell differentiation in hindbrain  (IEA,ISO)
cell fate commitment  (IBA)
cell fate determination  (IEA,ISO)
cell maturation  (IEA,ISO)
central nervous system neuron development  (IEA,ISO)
cochlea development  (ISO)
commitment of neuronal cell to specific neuron type in forebrain  (IEA,ISO)
definitive hemopoiesis  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
eosinophil fate commitment  (IEA)
GABAergic neuron differentiation  (IEA,ISO)
hemopoiesis  (IEA)
homeostasis of number of cells within a tissue  (IEA,ISO)
inner ear morphogenesis  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of fat cell proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of macrophage differentiation  (IEA,ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of neural precursor cell proliferation  (IEA,ISO)
negative regulation of Notch signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (ISO)
neuron fate commitment  (ISO)
neuron migration  (ISO)
pituitary gland development  (IEA,ISO)
positive regulation of angiogenesis  (IBA,IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of mast cell degranulation  (ISO)
positive regulation of megakaryocyte differentiation  (IEA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IBA,IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of forebrain neuron differentiation  (IEA,ISO)
regulation of histone acetylation  (IEA,ISO)
regulation of primitive erythrocyte differentiation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to lipid  (ISO)
semicircular canal development  (IEA,ISO)
somatic stem cell population maintenance  (IEA,ISO)
urogenital system development  (IEA,ISO)
vascular wound healing  (IEA)
ventral spinal cord interneuron differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
GATA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1371,984,063 - 71,997,622 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11371,981,139 - 71,997,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,606,930 - 79,613,715 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GATA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3128,479,427 - 128,493,201 (-)EnsemblGRCh38hg38GRCh38
GRCh383128,479,422 - 128,493,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373128,198,265 - 128,212,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,680,960 - 129,694,718 (-)NCBINCBI36hg18NCBI36
Build 343129,680,969 - 129,694,726NCBI
Celera3126,626,234 - 126,639,997 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,582,307 - 125,596,070 (-)NCBIHuRef
CHM1_13128,161,207 - 128,175,078 (-)NCBICHM1_1
Gata2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,170,873 - 88,184,014 (+)NCBIGRCm39mm39
GRCm39 Ensembl688,170,873 - 88,184,014 (+)Ensembl
GRCm38688,193,891 - 88,207,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,193,891 - 88,207,032 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,148,658 - 88,157,026 (+)NCBIGRCm37mm9NCBIm37
MGSCv36688,164,309 - 88,172,670 (+)NCBImm8
Celera690,136,051 - 90,144,243 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.2NCBI
Gata2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24120,654,205 - 120,667,763 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4120,658,986 - 120,667,761 (+)Ensembl
Rnor_6.04120,129,028 - 120,142,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,133,713 - 120,142,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04185,369,926 - 185,383,944 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,279,753 - 122,288,528 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14122,524,233 - 122,533,009 (+)NCBI
Celera4109,615,354 - 109,624,129 (+)NCBICelera
Cytogenetic Map4q34NCBI
Gata2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,327,113 - 15,336,460 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,326,551 - 15,334,774 (+)NCBIChiLan1.0ChiLan1.0
GATA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13132,890,508 - 132,899,035 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,890,508 - 132,899,035 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03125,526,537 - 125,535,649 (-)NCBIMhudiblu_PPA_v0panPan3
GATA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,472,251 - 2,488,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,473,912 - 2,480,991 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha202,508,307 - 2,517,105 (-)NCBI
ROS_Cfam_1.0202,492,701 - 2,501,504 (-)NCBI
UMICH_Zoey_3.1202,213,473 - 2,222,266 (-)NCBI
UNSW_CanFamBas_1.0202,540,074 - 2,548,847 (-)NCBI
UU_Cfam_GSD_1.0202,500,417 - 2,509,217 (-)NCBI
Gata2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,364,390 - 20,372,921 (+)NCBI
SpeTri2.0NW_004936798406,258 - 414,785 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,549,112 - 52,562,911 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2252,555,738 - 52,562,909 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041113,794,573 - 113,808,643 (-)NCBIVero_WHO_p1.0
Gata2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624961147,685 - 155,614 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 7 4 3 2 2 8 2 2
Below cutoff 3 3 15 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012715   ⟹   ENSSSCP00000012381
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1371,989,421 - 71,996,313 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041836   ⟹   ENSSSCP00000049777
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1371,984,063 - 71,997,622 (+)Ensembl
RefSeq Acc Id: NM_213879   ⟹   NP_999044
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11371,989,340 - 71,996,882 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068525   ⟹   XP_020924184
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11371,981,139 - 71,997,626 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068526   ⟹   XP_020924185
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11371,988,743 - 71,997,626 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999044 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924184 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924185 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO73945 (Get FASTA)   NCBI Sequence Viewer  
  AAQ16313 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020924184   ⟸   XM_021068525
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020924185   ⟸   XM_021068526
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999044   ⟸   NM_213879
- UniProtKB: Q865U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000049777   ⟸   ENSSSCT00000041836
RefSeq Acc Id: ENSSSCP00000012381   ⟸   ENSSSCT00000012715
Protein Domains
GATA-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070013302 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000012381 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049777 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070021545 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012715 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000041836 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070025959 UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/TrEMBL
InterPro GATA-2 UniProtKB/TrEMBL
  TF_GATA-2/3 UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/TrEMBL
  Znf_GATA UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report ssc:396912 UniProtKB/TrEMBL
NCBI Gene GATA2 ENTREZGENE
PANTHER PTHR10071 UniProtKB/TrEMBL
  PTHR10071:SF149 UniProtKB/TrEMBL
Pfam GATA UniProtKB/TrEMBL
PIRSF TF_GATA-1/2/3 UniProtKB/TrEMBL
PRINTS GATAZNFINGER UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/TrEMBL
UniProt A0A4X1U0Z2_PIG UniProtKB/TrEMBL
  F6Q9G0_PIG UniProtKB/TrEMBL
  Q6WL03_PIG UniProtKB/TrEMBL
  Q865U9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88364 ENTREZGENE