MAP3K2 (mitogen-activated protein kinase kinase kinase 2) - Rat Genome Database

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Gene: MAP3K2 (mitogen-activated protein kinase kinase kinase 2) Sus scrofa
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Symbol: MAP3K2
Name: mitogen-activated protein kinase kinase kinase 2
RGD ID: 14181443
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); INVOLVED IN protein phosphorylation (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Erk5 MAPK signaling pathway; ASSOCIATED WITH autosomal dominant thrombophilia due to protein C deficiency (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2W (ortholog); centronuclear myopathy 2 (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,087,738 - 25,178,060 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,087,479 - 25,184,106 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,766,719 - 28,864,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nucleoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MAP3K2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,087,738 - 25,178,060 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,087,479 - 25,184,106 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,766,719 - 28,864,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,298,668 - 127,388,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,298,668 - 127,388,465 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,056,244 - 128,146,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,778,609 - 127,817,240 (-)NCBINCBI36Build 36hg18NCBI36
Build 342127,780,007 - 127,817,035NCBI
Celera2121,373,314 - 121,412,005 (-)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,363,448 - 120,407,794 (-)NCBIHuRef
CHM1_12128,060,819 - 128,105,372 (-)NCBICHM1_1
T2T-CHM13v2.02127,733,893 - 127,823,745 (-)NCBIT2T-CHM13v2.0
Map3k2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,296,142 - 32,369,804 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,296,142 - 32,369,804 (+)EnsemblGRCm39 Ensembl
GRCm381832,163,089 - 32,236,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,163,089 - 32,236,751 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,322,743 - 32,396,405 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,306,212 - 32,371,521 (+)NCBIMGSCv36mm8
Celera1832,644,790 - 32,718,516 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.95NCBI
Map3k2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,081,444 - 24,153,940 (+)NCBIGRCr8
mRatBN7.21823,807,218 - 23,879,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,807,218 - 23,871,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,935,311 - 23,999,520 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,692,639 - 24,757,275 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01824,030,296 - 24,094,510 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,961,250 - 25,025,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,961,245 - 25,025,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,676,280 - 24,740,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,606,219 - 24,672,732 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,680,069 - 24,682,550 (+)NCBI
Celera1823,559,225 - 23,623,916 (+)NCBICelera
Cytogenetic Map18p12NCBI
Map3k2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,136,010 - 3,196,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,135,959 - 3,196,971 (+)NCBIChiLan1.0ChiLan1.0
MAP3K2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21348,257,665 - 48,347,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B48,272,647 - 48,362,285 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,889,499 - 32,979,077 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B127,963,999 - 128,008,773 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B127,972,900 - 128,008,766 (-)Ensemblpanpan1.1panPan2
MAP3K2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,210,106 - 23,303,426 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,210,714 - 23,294,586 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,457,614 - 23,550,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,536,705 - 24,630,042 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,519,123 - 24,622,032 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,240,311 - 23,333,600 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,434,707 - 23,529,263 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,567,169 - 24,660,474 (+)NCBIUU_Cfam_GSD_1.0
Map3k2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,654,640 - 97,736,974 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,880,468 - 43,958,556 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,880,816 - 43,958,556 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,831,265 - 2,921,782 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,831,270 - 2,912,897 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606119,831,765 - 19,921,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473213,790,080 - 13,877,598 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473213,790,088 - 13,877,641 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP3K2
2055 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000022881   ⟹   ENSSSCP00000027585
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,087,738 - 25,178,060 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000056882   ⟹   ENSSSCP00000059122
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,087,738 - 25,178,060 (+)Ensembl
RefSeq Acc Id: XM_003359437   ⟹   XP_003359485
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,087,479 - 25,184,106 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005671635   ⟹   XP_005671692
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,087,638 - 25,176,194 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003359485   ⟸   XM_003359437
- UniProtKB: A0A4X1SL77 (UniProtKB/TrEMBL),   A0A0B8RSM6 (UniProtKB/TrEMBL),   I3LTY6 (UniProtKB/TrEMBL),   A0A8D2BZM9 (UniProtKB/TrEMBL),   A0A8D0WI11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005671692   ⟸   XM_005671635
- UniProtKB: A0A4X1SL77 (UniProtKB/TrEMBL),   A0A0B8RSM6 (UniProtKB/TrEMBL),   I3LTY6 (UniProtKB/TrEMBL),   A0A8D2BZM9 (UniProtKB/TrEMBL),   A0A8D0WI11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000027585   ⟸   ENSSSCT00000022881
Ensembl Acc Id: ENSSSCP00000059122   ⟸   ENSSSCT00000056882
Protein Domains
PB1   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030354 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005002305 UniProtKB/TrEMBL
  ENSSSCG00015080615 UniProtKB/TrEMBL
  ENSSSCG00025030666 UniProtKB/TrEMBL
  ENSSSCG00030035284 UniProtKB/TrEMBL
  ENSSSCG00035067857 UniProtKB/TrEMBL
  ENSSSCG00040001516 UniProtKB/TrEMBL
  ENSSSCG00045016778 UniProtKB/TrEMBL
  ENSSSCG00050015379 UniProtKB/TrEMBL
  ENSSSCG00060046143 UniProtKB/TrEMBL
  ENSSSCG00065013854 UniProtKB/TrEMBL
  ENSSSCG00070002091 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000022881 ENTREZGENE
  ENSSSCT00000022881.3 UniProtKB/TrEMBL
  ENSSSCT00005003521.1 UniProtKB/TrEMBL
  ENSSSCT00005003528.1 UniProtKB/TrEMBL
  ENSSSCT00015109642.1 UniProtKB/TrEMBL
  ENSSSCT00015109657.1 UniProtKB/TrEMBL
  ENSSSCT00025041685.1 UniProtKB/TrEMBL
  ENSSSCT00030048911.1 UniProtKB/TrEMBL
  ENSSSCT00035091564.1 UniProtKB/TrEMBL
  ENSSSCT00035091587.1 UniProtKB/TrEMBL
  ENSSSCT00040001793.1 UniProtKB/TrEMBL
  ENSSSCT00045028500.1 UniProtKB/TrEMBL
  ENSSSCT00050020848.1 UniProtKB/TrEMBL
  ENSSSCT00060062620.1 UniProtKB/TrEMBL
  ENSSSCT00065018415.1 UniProtKB/TrEMBL
  ENSSSCT00065018422.1 UniProtKB/TrEMBL
  ENSSSCT00070003913.1 UniProtKB/TrEMBL
  ENSSSCT00070003930.1 UniProtKB/TrEMBL
  ENSSSCT00070003944.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_kinase_kinase UniProtKB/TrEMBL
  PB1-like UniProtKB/TrEMBL
  PB1_dom UniProtKB/TrEMBL
  PB1_MEKK2/3 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report ssc:100621234 UniProtKB/TrEMBL
NCBI Gene MAP3K2 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 15 UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam PB1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PB1 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART PB1 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0B8RSM6 ENTREZGENE
  A0A4X1SL77 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SL87_PIG UniProtKB/TrEMBL
  A0A4X1SLF7_PIG UniProtKB/TrEMBL
  A0A8D0WI11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2BZM9 ENTREZGENE, UniProtKB/TrEMBL
  I3LTY6 ENTREZGENE
UniProt Secondary I3LTY6 UniProtKB/TrEMBL
VGNC ID VGNC:98107 ENTREZGENE