KAT2B (lysine acetyltransferase 2B) - Rat Genome Database

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Gene: KAT2B (lysine acetyltransferase 2B) Sus scrofa
Analyze
Symbol: KAT2B
Name: lysine acetyltransferase 2B
RGD ID: 14179902
Description: ENCODES a protein that exhibits chromatin binding (ortholog); histone acetyltransferase binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); cellular response to parathyroid hormone stimulus (ortholog); gluconeogenesis (ortholog); PARTICIPATES IN cortisol signaling pathway; histone modification pathway; p53 signaling pathway; ASSOCIATED WITH 3p deletion syndrome (ortholog); breast cancer (ortholog); Coronary Disease (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); INTERACTS WITH deoxynivalenol; dibromine
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone acetyltransferase KAT2B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl136,985,235 - 7,100,345 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1136,985,151 - 7,099,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2137,975,063 - 8,051,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KAT2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl136,985,235 - 7,100,345 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1136,985,151 - 7,099,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2137,975,063 - 8,051,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38320,040,446 - 20,154,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl320,040,446 - 20,154,404 (+)EnsemblGRCh38hg38GRCh38
GRCh37320,081,938 - 20,195,896 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36320,056,528 - 20,170,900 (+)NCBINCBI36Build 36hg18NCBI36
Build 34320,056,527 - 20,170,898NCBI
Celera320,022,291 - 20,136,515 (+)NCBICelera
Cytogenetic Map3p24.3NCBI
HuRef320,021,882 - 20,135,958 (+)NCBIHuRef
CHM1_1320,033,609 - 20,147,728 (+)NCBICHM1_1
T2T-CHM13v2.0320,044,513 - 20,158,472 (+)NCBIT2T-CHM13v2.0
Kat2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391753,873,802 - 53,979,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1753,873,889 - 53,979,748 (+)EnsemblGRCm39 Ensembl
GRCm381753,566,774 - 53,672,721 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1753,566,861 - 53,672,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371753,706,640 - 53,812,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361753,032,244 - 53,137,649 (+)NCBIMGSCv36mm8
Celera1757,012,579 - 57,114,621 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1727.86NCBI
Kat2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr896,799,101 - 6,903,616 (+)NCBIGRCr8
mRatBN7.296,562,525 - 6,667,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl96,562,288 - 6,667,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.094,440,982 - 4,492,949 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl94,440,982 - 4,447,715 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.093,479,552 - 3,531,771 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49882,928 - 889,661NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19882,927 - 889,661NCBI
Cytogenetic Map9q11NCBI
Kat2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543012,128,069 - 12,198,117 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543012,109,493 - 12,196,102 (+)NCBIChiLan1.0ChiLan1.0
KAT2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2220,004,090 - 20,118,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1320,008,861 - 20,122,967 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0319,956,067 - 20,070,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1320,286,080 - 20,399,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl320,286,865 - 20,400,770 (+)Ensemblpanpan1.1panPan2
KAT2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12323,166,722 - 23,242,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2323,168,600 - 23,233,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2323,190,019 - 23,289,543 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02323,651,391 - 23,751,080 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2323,651,410 - 23,751,080 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12323,363,816 - 23,463,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02323,429,027 - 23,528,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02323,675,265 - 23,774,811 (-)NCBIUU_Cfam_GSD_1.0
Kat2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118179,183,147 - 179,277,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647312,344,343 - 12,417,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647312,341,545 - 12,415,637 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11564,769,590 - 64,885,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1564,770,185 - 64,886,219 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604137,788,721 - 37,904,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248215,387,212 - 5,489,013 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KAT2B
5656 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 6 4 3 5 2 23 2 2 3
Low 4 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000024917   ⟹   ENSSSCP00000026852
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl136,985,235 - 7,100,345 (+)Ensembl
RefSeq Acc Id: XM_021071366   ⟹   XP_020927025
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1136,985,151 - 7,099,771 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020927025 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000026852
  ENSSSCP00000026852.3
  ENSSSCP00005018659.1
  ENSSSCP00070030236.1
  ENSSSCP00070030252.1
GenBank Protein JAG69441 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_020927025   ⟸   XM_021071366
- UniProtKB: A0A8D0J0W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000026852   ⟸   ENSSSCT00000024917
Protein Domains
Bromo   N-acetyltransferase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024621 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005018831 UniProtKB/TrEMBL
  ENSSSCG00070018313 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024917 ENTREZGENE
  ENSSSCT00000024917.4 UniProtKB/TrEMBL
  ENSSSCT00005030557.1 UniProtKB/TrEMBL
  ENSSSCT00070036174.1 UniProtKB/TrEMBL
  ENSSSCT00070036193.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.920.10 UniProtKB/TrEMBL
  3.40.630.30 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  GCN5 UniProtKB/TrEMBL
  GCN5/PCAF UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
NCBI Gene KAT2B ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE KAT2B UniProtKB/TrEMBL
  PTHR45750 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
PIRSF Histone_acetylase_PCAF UniProtKB/TrEMBL
PRINTS BROMODOMAIN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  GNAT UniProtKB/TrEMBL
SMART BROMO UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/TrEMBL
  SSF55729 UniProtKB/TrEMBL
UniProt A0A4X1ULW4_PIG UniProtKB/TrEMBL
  A0A4X1UNH3_PIG UniProtKB/TrEMBL
  A0A8D0J0W9 ENTREZGENE, UniProtKB/TrEMBL
  I3LRW1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89304 ENTREZGENE