DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor) - Rat Genome Database

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Gene: DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor) Sus scrofa
Analyze
Symbol: DIMT1
Name: DIM1 rRNA methyltransferase and ribosome maturation factor
RGD ID: 14179025
Description: ENCODES a protein that exhibits 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity (inferred); methyltransferase activity (inferred); RNA binding (inferred); INVOLVED IN methylation (inferred); positive regulation of rRNA processing (inferred); ribosomal small subunit biogenesis (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytosol (inferred); nucleolus (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DIM1 dimethyladenosine transferase 1 homolog; DIMT1 rRNA methyltransferase and ribosome maturation factor; DIMT1, rRNA methyltransferase and ribosome maturation factor; probable dimethyladenosine transferase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1641,098,350 - 41,111,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11641,098,146 - 41,111,203 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DIMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1641,098,350 - 41,111,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11641,098,146 - 41,111,203 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DIMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38562,387,254 - 62,403,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl562,347,284 - 62,403,943 (-)EnsemblGRCh38hg38GRCh38
GRCh37561,683,081 - 61,699,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36561,720,108 - 61,735,485 (-)NCBINCBI36Build 36hg18NCBI36
Celera558,680,274 - 58,695,692 (-)NCBICelera
Cytogenetic Map5q12.1NCBI
HuRef558,640,805 - 58,656,022 (-)NCBIHuRef
CHM1_1561,684,014 - 61,699,390 (-)NCBICHM1_1
T2T-CHM13v2.0563,206,803 - 63,223,500 (-)NCBIT2T-CHM13v2.0
Dimt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913107,083,637 - 107,097,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13107,083,635 - 107,096,732 (+)EnsemblGRCm39 Ensembl
GRCm3813106,947,071 - 106,961,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13106,947,127 - 106,960,224 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713107,737,209 - 107,750,304 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613108,067,557 - 108,080,145 (+)NCBIMGSCv36mm8
Celera13111,282,959 - 111,296,073 (+)NCBICelera
Cytogenetic Map13D2.1NCBI
cM Map1358.06NCBI
Dimt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8240,076,622 - 40,101,792 (+)NCBIGRCr8
mRatBN7.2238,343,086 - 38,368,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl238,354,854 - 38,368,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx245,466,627 - 45,491,779 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0243,525,306 - 43,550,458 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0238,372,617 - 38,397,742 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0238,120,562 - 38,144,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl238,120,592 - 38,144,327 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0257,215,297 - 57,240,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4238,054,640 - 38,078,326 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1237,986,493 - 37,998,557 (+)NCBI
Celera234,210,842 - 34,234,518 (+)NCBICelera
Cytogenetic Map2q13NCBI
Dimt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554466,234,846 - 6,244,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554466,235,004 - 6,244,422 (+)NCBIChiLan1.0ChiLan1.0
DIMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2451,508,695 - 51,524,125 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1549,662,231 - 49,677,756 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0551,593,030 - 51,608,687 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1553,234,921 - 53,250,082 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl553,234,921 - 53,250,079 (+)Ensemblpanpan1.1panPan2
DIMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1248,716,849 - 48,728,707 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl248,723,281 - 48,728,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha245,727,739 - 45,739,660 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0249,194,826 - 49,206,753 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1246,263,594 - 46,275,508 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0247,050,549 - 47,062,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0247,906,987 - 47,918,910 (-)NCBIUU_Cfam_GSD_1.0
Dimt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213197,374,959 - 197,386,446 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364806,311,445 - 6,327,065 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364806,311,389 - 6,323,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1458,568,080 - 58,583,582 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl458,568,567 - 58,583,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660497,097,875 - 7,112,892 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dimt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248157,492,402 - 7,504,157 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248157,492,384 - 7,503,593 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DIMT1
155 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000062892   ⟹   ENSSSCP00000039889
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1641,098,350 - 41,111,220 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000067478   ⟹   ENSSSCP00000072219
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1641,098,963 - 41,111,187 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086482   ⟹   ENSSSCP00000064094
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1641,102,322 - 41,111,229 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000099583   ⟹   ENSSSCP00000076938
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1641,098,350 - 41,111,220 (-)Ensembl
RefSeq Acc Id: NM_001244313   ⟹   NP_001231242
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11641,098,966 - 41,111,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021076560   ⟹   XP_020932219
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11641,098,146 - 41,109,219 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020932219   ⟸   XM_021076560
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001231242   ⟸   NM_001244313
- UniProtKB: A0A287A7N7 (UniProtKB/TrEMBL),   A0A4X1UU74 (UniProtKB/TrEMBL),   A0A8W4FCE7 (UniProtKB/TrEMBL),   A0A8D0UKL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000064094   ⟸   ENSSSCT00000086482
RefSeq Acc Id: ENSSSCP00000039889   ⟸   ENSSSCT00000062892
RefSeq Acc Id: ENSSSCP00000072219   ⟸   ENSSSCT00000067478
RefSeq Acc Id: ENSSSCP00000076938   ⟸   ENSSSCT00000099583
Protein Domains
Ribosomal RNA adenine methylase transferase N-


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005007949 UniProtKB/TrEMBL
  ENSSSCG00015062558 UniProtKB/TrEMBL
  ENSSSCG00025020568 UniProtKB/TrEMBL
  ENSSSCG00030008207 UniProtKB/TrEMBL
  ENSSSCG00035028251 UniProtKB/TrEMBL
  ENSSSCG00040073514 UniProtKB/TrEMBL
  ENSSSCG00045036859 UniProtKB/TrEMBL
  ENSSSCG00050011367 UniProtKB/TrEMBL
  ENSSSCG00055019085 UniProtKB/TrEMBL
  ENSSSCG00060060086 UniProtKB/TrEMBL
  ENSSSCG00065060933 UniProtKB/TrEMBL
  ENSSSCG00070019475 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000062892 ENTREZGENE
  ENSSSCT00000062892.3 UniProtKB/TrEMBL
  ENSSSCT00000067478.1 UniProtKB/TrEMBL
  ENSSSCT00000086482.1 UniProtKB/TrEMBL
  ENSSSCT00000099583.1 UniProtKB/TrEMBL
  ENSSSCT00005012185.1 UniProtKB/TrEMBL
  ENSSSCT00015083615.1 UniProtKB/TrEMBL
  ENSSSCT00025027967.1 UniProtKB/TrEMBL
  ENSSSCT00030011136.1 UniProtKB/TrEMBL
  ENSSSCT00035037361.1 UniProtKB/TrEMBL
  ENSSSCT00040101459.1 UniProtKB/TrEMBL
  ENSSSCT00045063783.1 UniProtKB/TrEMBL
  ENSSSCT00050015298.1 UniProtKB/TrEMBL
  ENSSSCT00055037367.1 UniProtKB/TrEMBL
  ENSSSCT00060081992.1 UniProtKB/TrEMBL
  ENSSSCT00065083492.1 UniProtKB/TrEMBL
  ENSSSCT00070038526.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.480 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
InterPro KsgA/Erm UniProtKB/TrEMBL
  rRNA_Ade_Mease_Trfase_CS UniProtKB/TrEMBL
  rRNA_Ade_methylase_Trfase_N UniProtKB/TrEMBL
  rRNA_adenine_dimethylase UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report ssc:100625553 UniProtKB/TrEMBL
NCBI Gene DIMT1 ENTREZGENE
PANTHER DIMETHYLADENOSINE TRANSFERASE-RELATED UniProtKB/TrEMBL
  PTHR11727 UniProtKB/TrEMBL
Pfam RrnaAD UniProtKB/TrEMBL
PROSITE RRNA_A_DIMETH UniProtKB/TrEMBL
  SAM_RNA_A_N6_MT UniProtKB/TrEMBL
SMART rADc UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A287A7N7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UU74 ENTREZGENE
  A0A5G2QPU5_PIG UniProtKB/TrEMBL
  A0A5G2RJU4_PIG UniProtKB/TrEMBL
  A0A8D0UKL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FCE7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1UU74 UniProtKB/TrEMBL
VGNC ID VGNC:87303 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-24 DIMT1  DIM1 rRNA methyltransferase and ribosome maturation factor  DIMT1  DIMT1 rRNA methyltransferase and ribosome maturation factor  Symbol and/or name change 19259463 PROVISIONAL
2019-03-19 DIMT1  DIMT1 rRNA methyltransferase and ribosome maturation factor    DIMT1, rRNA methyltransferase and ribosome maturation factor  Symbol and/or name change 5135510 APPROVED
2019-03-12 DIMT1  DIMT1, rRNA methyltransferase and ribosome maturation factor    DIM1 dimethyladenosine transferase 1 homolog  Symbol and/or name change 5135510 APPROVED