GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) - Rat Genome Database

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Pathways
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Gene: GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) Sus scrofa
Analyze
Symbol: GRIN1
Name: glutamate ionotropic receptor NMDA type subunit 1
RGD ID: 14178856
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); calcium channel activity (ortholog); calcium ion binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); associative learning (ortholog); calcium ion homeostasis (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); alcohol use disorder (ortholog); Alzheimer's disease (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate receptor ionotropic, NMDA 1; N-methyl-D-aspartate receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
associative learning  (ISO)
calcium ion homeostasis  (ISO)
calcium ion transmembrane import into cytosol  (IEA)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cell surface receptor signaling pathway  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to glycine  (ISO)
cellular response to manganese ion  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IBA,IEA)
conditioned taste aversion  (ISO)
excitatory postsynaptic potential  (ISO)
intracellular calcium ion homeostasis  (ISO)
ionotropic glutamate receptor signaling pathway  (IBA,IEA,ISO)
learning  (ISO)
learning or memory  (ISO)
long-term memory  (ISO)
male mating behavior  (ISO)
memory  (ISO)
monoatomic cation transmembrane transport  (ISO)
monoatomic cation transport  (IEA,ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of neuron apoptotic process  (ISO)
neuromuscular process  (ISO)
neuron cellular homeostasis  (ISO)
olfactory learning  (ISO)
pons maturation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of Schwann cell migration  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (ISO)
propylene metabolic process  (ISO)
protein heterotetramerization  (ISO)
protein localization to postsynaptic membrane  (ISO)
protein-containing complex assembly  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell communication  (ISO)
regulation of dendrite morphogenesis  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of membrane potential  (IBA,IEA,ISO)
regulation of monoatomic cation transmembrane transport  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of respiratory gaseous exchange  (ISO)
regulation of synapse assembly  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
response to ethanol  (IEA)
response to fungicide  (ISO)
response to glycine  (IEA)
response to hypoxia  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
rhythmic process  (ISO)
sensory perception of pain  (ISO)
social behavior  (ISO)
startle response  (ISO)
suckling behavior  (ISO)
synaptic transmission, glutamatergic  (ISO)
transcription by RNA polymerase II  (ISO)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GRIN1
(Sus scrofa - pig)		 No map positions available.
GRIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,139,154 - 137,168,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,138,346 - 137,168,756 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,033,606 - 140,063,208 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,153,430 - 139,183,029 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,308,678 - 137,339,043NCBI
Celera9110,548,072 - 110,577,040 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,493,914 - 109,523,231 (+)NCBIHuRef
CHM1_19140,182,355 - 140,211,903 (+)NCBICHM1_1
T2T-CHM13v2.09149,377,044 - 149,406,436 (+)NCBIT2T-CHM13v2.0
Grin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,181,189 - 25,209,199 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,181,193 - 25,209,199 (-)EnsemblGRCm39 Ensembl
GRCm38225,291,177 - 25,319,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,291,181 - 25,319,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,146,697 - 25,174,683 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,114,256 - 25,140,988 (-)NCBIMGSCv36mm8
Celera225,018,687 - 25,046,664 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.14NCBI
Grin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,501,836 - 28,528,754 (-)NCBIGRCr8
mRatBN7.238,103,680 - 8,130,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,208,200 - 11,235,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,794,430 - 19,821,357 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,984,273 - 18,011,200 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,507,745 - 2,534,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,896 - 2,534,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,489,158 - 2,516,082 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,453,784 - 3,480,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,453,783 - 3,480,381 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBICelera
Cytogenetic Map3p13NCBI
Grin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,154,864 - 5,178,636 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,154,864 - 5,178,636 (+)NCBIChiLan1.0ChiLan1.0
GRIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,230,366 - 2,260,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,232,699 - 2,262,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,198,350 - 108,228,887 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,168,543 - 137,198,297 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,168,722 - 137,197,382 (+)Ensemblpanpan1.1panPan2
GRIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,492,967 - 48,513,981 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,683,789 - 47,707,011 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,357,798 - 49,382,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,357,798 - 49,383,084 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,135,045 - 48,158,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,433,856 - 48,457,059 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,481,015 - 48,504,246 (-)NCBIUU_Cfam_GSD_1.0
Grin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,536,077 - 202,560,723 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669814,330 - 839,208 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669814,330 - 838,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,020,556 - 1,050,568 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,019,263 - 1,050,231 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,254,719 - 4,284,702 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760776,873 - 801,354 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760777,208 - 800,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 18
Low 2 1
Below cutoff 6 3 1 2 3 1

Sequence


Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039834 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025069344 UniProtKB/TrEMBL
  ENSSSCG00030056870 UniProtKB/TrEMBL
  ENSSSCG00035018594 UniProtKB/TrEMBL
  ENSSSCG00045027242 UniProtKB/TrEMBL
  ENSSSCG00050034163 UniProtKB/TrEMBL
  ENSSSCG00055000952 UniProtKB/TrEMBL
  ENSSSCG00060010820 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039946 ENTREZGENE
  ENSSSCT00000039946.3 UniProtKB/TrEMBL
  ENSSSCT00000043291 ENTREZGENE
  ENSSSCT00000043291.3 UniProtKB/TrEMBL
  ENSSSCT00000103069.1 UniProtKB/TrEMBL
  ENSSSCT00025095363.1 UniProtKB/TrEMBL
  ENSSSCT00025095639.1 UniProtKB/TrEMBL
  ENSSSCT00025095954.1 UniProtKB/TrEMBL
  ENSSSCT00030079331.1 UniProtKB/TrEMBL
  ENSSSCT00030079400.1 UniProtKB/TrEMBL
  ENSSSCT00030079520.1 UniProtKB/TrEMBL
  ENSSSCT00035024020.1 UniProtKB/TrEMBL
  ENSSSCT00035024048.1 UniProtKB/TrEMBL
  ENSSSCT00035024073.1 UniProtKB/TrEMBL
  ENSSSCT00045050772.1 UniProtKB/TrEMBL
  ENSSSCT00045051004.1 UniProtKB/TrEMBL
  ENSSSCT00045051321.1 UniProtKB/TrEMBL
  ENSSSCT00050045815.1 UniProtKB/TrEMBL
  ENSSSCT00050045828.1 UniProtKB/TrEMBL
  ENSSSCT00055001751.1 UniProtKB/TrEMBL
  ENSSSCT00055001784.1 UniProtKB/TrEMBL
  ENSSSCT00055001849.1 UniProtKB/TrEMBL
  ENSSSCT00060014314.1 UniProtKB/TrEMBL
  ENSSSCT00060014342.1 UniProtKB/TrEMBL
  ENSSSCT00060014366.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
  Solute-binding_3/MltF_N UniProtKB/TrEMBL
NCBI Gene GRIN1 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1 UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/TrEMBL
  Lig_chan UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/TrEMBL
  SBP_bac_3 UniProtKB/TrEMBL
PRINTS NMDARECEPTOR UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/TrEMBL
  PBPe UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/TrEMBL
  SSF53822 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A286ZIR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AWP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B0D3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0V010 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XFS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IMD5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IS59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PCA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FJ19_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88682 ENTREZGENE