GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) - Rat Genome Database

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Gene: GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) Sus scrofa
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Symbol: GRIN1
Name: glutamate ionotropic receptor NMDA type subunit 1
RGD ID: 14178856
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); calcium channel activity (ortholog); calcium ion binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); associative learning (ortholog); calcium ion homeostasis (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: glutamate receptor ionotropic, NMDA 1; N-methyl-D-aspartate receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position: No map positions available.


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
associative learning  (ISO)
calcium ion homeostasis  (ISO)
calcium ion transmembrane import into cytosol  (IEA)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cation transport  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to manganese ion  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IBA)
conditioned taste aversion  (ISO)
excitatory postsynaptic potential  (ISO)
ion transmembrane transport  (IEA)
ionotropic glutamate receptor signaling pathway  (IBA,IEA,ISO)
learning  (ISO)
learning or memory  (ISO)
long-term memory  (ISO)
male mating behavior  (ISO)
memory  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuromuscular process  (ISO)
olfactory learning  (ISO)
pons maturation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of Schwann cell migration  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (ISO)
propylene metabolic process  (ISO)
protein heterotetramerization  (ISO)
protein localization to postsynaptic membrane  (ISO)
protein-containing complex assembly  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell communication  (ISO)
regulation of dendrite morphogenesis  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of membrane potential  (IBA,ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of respiratory gaseous exchange  (ISO)
regulation of synapse assembly  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
response to ethanol  (IEA)
response to fungicide  (ISO)
response to glycine  (IEA)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
rhythmic process  (ISO)
sensory perception of pain  (ISO)
social behavior  (ISO)
startle response  (ISO)
suckling behavior  (ISO)
synaptic transmission, glutamatergic  (ISO)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
GRIN1
(Sus scrofa - pig)
No map positions available.
GRIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9137,139,154 - 137,168,756 (+)EnsemblGRCh38hg38GRCh38
GRCh389137,139,092 - 137,168,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379140,033,606 - 140,063,208 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,153,430 - 139,183,029 (+)NCBINCBI36hg18NCBI36
Build 349137,308,678 - 137,339,043NCBI
Celera9110,548,072 - 110,577,040 (+)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,493,914 - 109,523,231 (+)NCBIHuRef
CHM1_19140,182,355 - 140,211,903 (+)NCBICHM1_1
Grin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,181,189 - 25,209,199 (-)NCBIGRCm39mm39
GRCm39 Ensembl225,181,193 - 25,209,199 (-)Ensembl
GRCm38225,291,177 - 25,319,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,291,181 - 25,319,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,146,697 - 25,174,683 (-)NCBIGRCm37mm9NCBIm37
MGSCv36225,114,256 - 25,140,988 (-)NCBImm8
Celera225,018,687 - 25,046,664 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.14NCBI
Grin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,103,680 - 8,130,603 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)Ensembl
Rnor_6.032,507,745 - 2,534,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,896 - 2,534,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,489,158 - 2,516,082 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,453,784 - 3,480,381 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.133,453,783 - 3,480,381 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBICelera
Cytogenetic Map3p13NCBI
Grin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,154,864 - 5,178,636 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,154,864 - 5,178,636 (+)NCBIChiLan1.0ChiLan1.0
GRIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,168,543 - 137,198,297 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,168,722 - 137,197,382 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,198,350 - 108,228,887 (+)NCBIMhudiblu_PPA_v0panPan3
GRIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,492,967 - 48,513,981 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,683,789 - 47,707,011 (-)NCBI
ROS_Cfam_1.0949,357,798 - 49,382,176 (-)NCBI
UMICH_Zoey_3.1948,135,045 - 48,158,254 (-)NCBI
UNSW_CanFamBas_1.0948,433,856 - 48,457,059 (-)NCBI
UU_Cfam_GSD_1.0948,481,015 - 48,504,246 (-)NCBI
Grin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,536,077 - 202,560,723 (+)NCBI
SpeTri2.0NW_004936669814,330 - 838,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,020,556 - 1,050,568 (-)NCBI
ChlSab1.1 Ensembl121,019,263 - 1,050,231 (-)Ensembl
Vero_WHO_p1.0NW_0236660584,254,719 - 4,284,702 (+)NCBI
Grin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624760777,208 - 800,525 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 18
Low 2 1
Below cutoff 6 3 1 2 3 1

Sequence


Protein Domains
Lig_chan-Glu_bd   PBPe


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039834 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000031446 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049878 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039946 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000043291 ENTREZGENE, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  CaM-bd_C0_NMDA_rcpt_NR1 UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
NCBI Gene GRIN1 ENTREZGENE
Pfam ANF_receptor UniProtKB/TrEMBL
  CaM_bdg_C0 UniProtKB/TrEMBL
  Lig_chan UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/TrEMBL
PRINTS NMDARECEPTOR UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/TrEMBL
  PBPe UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A286ZIR4_PIG UniProtKB/TrEMBL
  A0A287B0D3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88682 ENTREZGENE