TBX5 (T-box transcription factor 5) - Rat Genome Database

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Gene: TBX5 (T-box transcription factor 5) Sus scrofa
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Symbol: TBX5
Name: T-box transcription factor 5
RGD ID: 14174191
Description: ENCODES a protein that exhibits RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN atrial septum development (ortholog); atrial septum morphogenesis (ortholog); atrioventricular valve morphogenesis (ortholog); ASSOCIATED WITH aortic valve disease 2 (ortholog); atrial fibrillation (ortholog); atrial heart septal defect (ortholog); FOUND IN nucleus (ortholog); protein-containing complex (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: T-box 5; T-box transcription factor TBX5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,773,605 - 37,824,400 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,772,205 - 37,826,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,161,963 - 40,260,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial septum development  (ISO)
atrial septum morphogenesis  (IEA,ISO)
atrioventricular bundle cell differentiation  (IEA)
atrioventricular node cell development  (IEA)
atrioventricular node cell fate commitment  (IEA)
atrioventricular valve morphogenesis  (IEA,ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IEA,ISO)
bundle of His development  (ISO)
cardiac left ventricle formation  (IBA)
cardiac muscle cell differentiation  (ISO)
cell fate specification  (IBA)
cell-cell signaling  (ISO)
cell-cell signaling involved in cardiac conduction  (IEA,ISO)
embryonic forelimb morphogenesis  (IBA,ISO)
embryonic limb morphogenesis  (ISO)
endocardial cushion development  (IEA,ISO)
forelimb morphogenesis  (ISO)
heart development  (ISO)
lung development  (IEA,ISO)
morphogenesis of an epithelium  (IEA,ISO)
negative regulation of cardiac muscle cell proliferation  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (ISO)
pattern specification process  (IBA,ISO)
pericardium development  (IEA)
positive regulation of cardiac conduction  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of cardioblast differentiation  (IEA)
positive regulation of gap junction assembly  (IEA)
positive regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA,ISO)
transdifferentiation  (ISO)
ventricular cardiac muscle tissue development  (ISO)
ventricular septum development  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:26575833  


Genomics

Comparative Map Data
TBX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,773,605 - 37,824,400 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,772,205 - 37,826,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,161,963 - 40,260,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12114,353,911 - 114,408,442 (-)EnsemblGRCh38hg38GRCh38
GRCh3812114,353,911 - 114,408,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712114,791,716 - 114,846,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612113,276,118 - 113,330,630 (-)NCBINCBI36hg18NCBI36
Celera12114,419,103 - 114,473,633 (-)NCBI
Cytogenetic Map12q24.21NCBI
HuRef12111,801,135 - 111,855,628 (-)NCBIHuRef
CHM1_112114,759,933 - 114,814,388 (-)NCBICHM1_1
Tbx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,934,581 - 120,023,285 (+)NCBIGRCm39mm39
GRCm39 Ensembl5119,970,733 - 120,023,284 (+)Ensembl
GRCm385119,796,514 - 119,885,220 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,832,668 - 119,885,219 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,284,672 - 120,335,227 (+)NCBIGRCm37mm9NCBIm37
MGSCv365120,095,280 - 120,145,092 (+)NCBImm8
Celera5116,903,647 - 116,978,836 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.42NCBI
Tbx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21236,686,344 - 36,739,253 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1236,688,014 - 36,734,885 (-)Ensembl
Rnor_6.01242,059,688 - 42,148,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,097,626 - 42,148,146 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,909,016 - 43,998,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,956,658 - 38,004,255 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11237,820,045 - 37,867,643 (-)NCBI
Celera1238,362,373 - 38,409,445 (-)NCBICelera
Cytogenetic Map12q16NCBI
Tbx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545516,132,975 - 16,217,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545516,133,130 - 16,217,894 (+)NCBIChiLan1.0ChiLan1.0
TBX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112115,336,267 - 115,389,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12115,333,609 - 115,389,739 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012111,954,222 - 112,009,261 (-)NCBIMhudiblu_PPA_v0panPan3
TBX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12611,462,541 - 11,549,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2611,463,653 - 11,506,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2611,520,894 - 11,607,938 (-)NCBI
ROS_Cfam_1.02611,714,458 - 11,801,523 (-)NCBI
UMICH_Zoey_3.12611,682,098 - 11,768,911 (-)NCBI
UNSW_CanFamBas_1.02611,744,240 - 11,831,307 (-)NCBI
UU_Cfam_GSD_1.02611,794,191 - 11,881,084 (-)NCBI
Tbx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBI
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111109,638,694 - 109,696,619 (-)NCBI
ChlSab1.1 Ensembl11109,638,715 - 109,689,177 (-)Ensembl
Vero_WHO_p1.0NW_023666037135,422,975 - 135,477,375 (+)NCBI
Tbx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474718,307,294 - 18,348,040 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system musculoskeletal system nervous system reproductive system
High
Medium
Low 2 2 1
Below cutoff 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010815   ⟹   ENSSSCP00000010532
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1437,773,605 - 37,824,400 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050467   ⟹   ENSSSCP00000054910
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1437,774,170 - 37,824,400 (+)Ensembl
RefSeq Acc Id: XM_013982910   ⟹   XP_013838364
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11437,773,395 - 37,826,015 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013982911   ⟹   XP_013838365
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11437,773,401 - 37,826,015 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013982912   ⟹   XP_013838366
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11437,774,486 - 37,825,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013982915   ⟹   XP_013838369
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11437,772,205 - 37,825,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072761   ⟹   XP_020928420
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11437,776,024 - 37,826,015 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013838369   ⟸   XM_013982915
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013838364   ⟸   XM_013982910
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013838365   ⟸   XM_013982911
- Peptide Label: isoform X2
- UniProtKB: F1RKD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013838366   ⟸   XM_013982912
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020928420   ⟸   XM_021072761
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000054910   ⟸   ENSSSCT00000050467
RefSeq Acc Id: ENSSSCP00000010532   ⟸   ENSSSCT00000010815


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009867 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070010010 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010532 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000054910 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070016173 UniProtKB/TrEMBL
  ENSSSCP00070016184 UniProtKB/TrEMBL
  ENSSSCP00070016195 UniProtKB/TrEMBL
  ENSSSCP00070016201 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010815 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000050467 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070019437 UniProtKB/TrEMBL
  ENSSSCT00070019450 UniProtKB/TrEMBL
  ENSSSCT00070019462 UniProtKB/TrEMBL
  ENSSSCT00070019470 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
NCBI Gene TBX5 ENTREZGENE
PANTHER PTHR11267 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
PRINTS TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A287BFS2_PIG UniProtKB/TrEMBL
  A0A4X1TJI9_PIG UniProtKB/TrEMBL
  A0A4X1TJK0_PIG UniProtKB/TrEMBL
  B0JF98_PIG UniProtKB/TrEMBL
  F1RKD2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93804 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 TBX5  T-box transcription factor 5  TBX5  T-box 5  Symbol and/or name change 5135510 APPROVED