PLA2G3 (phospholipase A2 group III) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: PLA2G3 (phospholipase A2 group III) Sus scrofa
Analyze
Symbol: PLA2G3
Name: phospholipase A2 group III
RGD ID: 14172238
Description: ENCODES a protein that exhibits calcium-dependent phospholipase A2 activity (inferred); phospholipase A2 activity (inferred); phospholipase activity (inferred); INVOLVED IN acrosome assembly (ortholog); cell development (ortholog); cell maturation (ortholog); FOUND IN centriole (inferred); extracellular region (inferred); recycling endosome (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: group 3 secretory phospholipase A2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,923,954 - 47,928,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,923,005 - 47,928,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,034,721 - 51,040,254 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acrosome assembly  (IEA,ISO)
arachidonate secretion  (IEA)
cell development  (IEA,ISO)
cell maturation  (IEA,ISO)
cilium assembly  (IEA)
high-density lipoprotein particle remodeling  (IEA)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
lipoxygenase pathway  (IEA,ISO)
low-density lipoprotein particle remodeling  (IEA)
macrophage activation  (IEA,ISO)
mast cell degranulation  (IEA,ISO)
negative regulation of amyloid-beta clearance  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA)
phosphatidic acid metabolic process  (IEA)
phosphatidylcholine metabolic process  (IEA,ISO)
phosphatidylethanolamine metabolic process  (IEA)
phosphatidylglycerol metabolic process  (IEA)
phosphatidylinositol metabolic process  (IEA)
phosphatidylserine metabolic process  (IEA)
phospholipid metabolic process  (IEA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of histamine secretion by mast cell  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of mast cell differentiation  (IEA)
positive regulation of neuron projection development  (IEA)
positive regulation of prostaglandin biosynthetic process  (IEA)
positive regulation of prostaglandin secretion  (IEA,ISO)
production of molecular mediator involved in inflammatory response  (IEA,ISO)
regulation of endocytic recycling  (IEA)
sperm axoneme assembly  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
PLA2G3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,923,954 - 47,928,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,923,005 - 47,928,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,034,721 - 51,040,254 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,134,807 - 31,140,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,134,807 - 31,140,508 (-)EnsemblGRCh38hg38GRCh38
GRCh372231,530,793 - 31,536,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,860,793 - 29,866,469 (-)NCBINCBI36Build 36hg18NCBI36
Build 342229,855,346 - 29,861,023NCBI
Celera2215,330,868 - 15,336,544 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,492,451 - 14,498,127 (-)NCBIHuRef
CHM1_12231,490,658 - 31,496,334 (-)NCBICHM1_1
T2T-CHM13v2.02231,598,311 - 31,604,012 (-)NCBIT2T-CHM13v2.0
Pla2g3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,438,158 - 3,449,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,438,284 - 3,449,350 (+)EnsemblGRCm39 Ensembl
GRCm38113,488,158 - 3,499,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,488,284 - 3,499,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,388,230 - 3,394,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,388,302 - 3,399,353 (+)NCBIMGSCv36mm8
Celera113,979,003 - 3,985,078 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.45NCBI
Pla2g3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,589,908 - 82,597,542 (+)NCBIGRCr8
mRatBN7.21478,367,625 - 78,373,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,368,105 - 78,373,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,809,429 - 82,815,114 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,049,536 - 84,055,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,495,298 - 80,500,983 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,724,828 - 83,730,614 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,724,933 - 83,730,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,412,999 - 84,418,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,119,872 - 84,125,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,130,645 - 84,143,800 (+)NCBI
Celera1477,281,569 - 77,287,249 (+)NCBICelera
Cytogenetic Map14q21NCBI
Pla2g3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,315,450 - 5,320,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554555,314,520 - 5,320,151 (-)NCBIChiLan1.0ChiLan1.0
PLA2G3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22341,090,380 - 41,100,730 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,788,928 - 43,799,272 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02212,158,589 - 12,164,441 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,995,364 - 30,001,160 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,995,364 - 30,001,160 (-)Ensemblpanpan1.1panPan2
PLA2G3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,127,074 - 24,132,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,128,005 - 24,132,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,994,204 - 24,002,589 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,506,855 - 24,515,226 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,510,739 - 24,515,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12624,210,260 - 24,218,645 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,472,253 - 24,480,619 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,533,532 - 24,541,902 (-)NCBIUU_Cfam_GSD_1.0
Pla2g3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,049,648 - 117,058,557 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936755306,313 - 312,683 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936755307,166 - 312,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,025,373 - 14,033,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,025,742 - 14,030,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,087,770 - 112,093,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247477,603,277 - 7,607,753 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247477,602,848 - 7,607,872 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G3
59 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 23 3 1 8 5 23 1 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000010980   ⟹   ENSSSCP00000010694
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,923,954 - 47,928,810 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000058796   ⟹   ENSSSCP00000043873
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,923,787 - 47,928,810 (-)Ensembl
RefSeq Acc Id: XM_003132975   ⟹   XP_003133023
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,923,005 - 47,928,309 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021072944   ⟹   XP_020928603
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,924,770 - 47,928,762 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003133023   ⟸   XM_003132975
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VBN7 (UniProtKB/TrEMBL),   A0A8D2C557 (UniProtKB/TrEMBL),   A0A8D1GL39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928603   ⟸   XM_021072944
- Peptide Label: isoform X2
- UniProtKB: A0A8D2C557 (UniProtKB/TrEMBL),   A0A8D1GL39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000043873   ⟸   ENSSSCT00000058796
Ensembl Acc Id: ENSSSCP00000010694   ⟸   ENSSSCT00000010980
Protein Domains
Phospholipase A2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010023 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025066813 UniProtKB/TrEMBL
  ENSSSCG00040006467 UniProtKB/TrEMBL
  ENSSSCG00045003641 UniProtKB/TrEMBL
  ENSSSCG00055007974 UniProtKB/TrEMBL
  ENSSSCG00065033265 UniProtKB/TrEMBL
  ENSSSCG00070022778 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010980 ENTREZGENE
  ENSSSCT00000010980.5 UniProtKB/TrEMBL
  ENSSSCT00025091767.1 UniProtKB/TrEMBL
  ENSSSCT00025091879.1 UniProtKB/TrEMBL
  ENSSSCT00040008497.1 UniProtKB/TrEMBL
  ENSSSCT00045005986.1 UniProtKB/TrEMBL
  ENSSSCT00055015574.1 UniProtKB/TrEMBL
  ENSSSCT00065045212.1 UniProtKB/TrEMBL
  ENSSSCT00070045312.1 UniProtKB/TrEMBL
  ENSSSCT00070045313.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
KEGG Report ssc:100511161 UniProtKB/TrEMBL
NCBI Gene PLA2G3 ENTREZGENE
PANTHER FI07253P-RELATED UniProtKB/TrEMBL
  GROUP 3 SECRETORY PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  RH14732P UniProtKB/TrEMBL
Pfam Phospholip_A2_2 UniProtKB/TrEMBL
PROSITE PA2_HIS UniProtKB/TrEMBL
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A0A4X1V9F3_PIG UniProtKB/TrEMBL
  A0A4X1VBN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GL39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2C557 ENTREZGENE
  F1RPC3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91494 ENTREZGENE