TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2) - Rat Genome Database

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Gene: TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2) Sus scrofa
Analyze
Symbol: TMTC2
Name: transmembrane O-mannosyltransferase targeting cadherins 2
RGD ID: 14172044
Description: ENCODES a protein that exhibits dolichyl-phosphate-mannose-protein mannosyltransferase activity (inferred); mannosyltransferase activity (inferred); INVOLVED IN calcium ion homeostasis (inferred); protein glycosylation (inferred); protein O-linked mannosylation (inferred); ASSOCIATED WITH COVID-19 (ortholog); Deafness (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transmembrane and tetratricopeptide repeat containing 2; transmembrane and TPR repeat-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl598,697,035 - 99,229,550 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1598,695,404 - 99,085,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25103,474,951 - 103,667,323 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TMTC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl598,697,035 - 99,229,550 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1598,695,404 - 99,085,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25103,474,951 - 103,667,323 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMTC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381282,686,906 - 83,134,866 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1282,686,880 - 83,134,870 (+)EnsemblGRCh38hg38GRCh38
GRCh371283,080,685 - 83,528,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361281,605,065 - 82,052,196 (+)NCBINCBI36Build 36hg18NCBI36
Celera1282,748,495 - 83,195,421 (+)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1280,139,235 - 80,586,094 (+)NCBIHuRef
CHM1_11283,046,833 - 83,493,575 (+)NCBICHM1_1
T2T-CHM13v2.01282,666,441 - 83,114,534 (+)NCBIT2T-CHM13v2.0
Tmtc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910105,023,524 - 105,410,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10105,023,524 - 105,410,312 (-)EnsemblGRCm39 Ensembl
GRCm3810105,187,663 - 105,574,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10105,187,663 - 105,574,451 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710104,624,719 - 105,011,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610104,591,773 - 104,978,561 (-)NCBIMGSCv36mm8
Celera10107,116,217 - 107,505,137 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1054.72NCBI
Tmtc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8742,280,746 - 42,695,651 (-)NCBIGRCr8
mRatBN7.2740,392,377 - 40,806,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl740,394,220 - 40,807,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx742,297,607 - 42,708,576 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0744,500,689 - 44,911,641 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0744,275,578 - 44,686,535 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0747,179,596 - 47,586,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl747,181,981 - 47,586,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0747,197,110 - 47,603,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4743,667,983 - 44,133,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1743,688,792 - 44,154,492 (-)NCBI
Celera737,294,447 - 37,702,308 (-)NCBICelera
Cytogenetic Map7q21NCBI
Tmtc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540520,969,952 - 21,359,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540520,969,836 - 21,357,939 (+)NCBIChiLan1.0ChiLan1.0
TMTC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21090,738,676 - 91,185,559 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11290,735,094 - 91,186,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01280,209,070 - 80,660,058 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11283,316,647 - 83,761,761 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1283,317,358 - 83,759,281 (+)Ensemblpanpan1.1panPan2
TMTC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11524,629,610 - 25,017,936 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1524,629,157 - 25,016,555 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1525,060,632 - 25,448,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01525,377,180 - 25,529,388 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1525,008,752 - 25,526,997 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11524,585,728 - 24,973,537 (+)NCBIUMICH_Zoey_3.1
Tmtc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494535,255,207 - 35,632,245 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936507603,868 - 980,230 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936507603,222 - 980,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMTC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11178,130,490 - 78,569,546 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1178,296,438 - 78,569,740 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037166,791,023 - 167,244,956 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmtc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248371,998,083 - 2,398,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248371,998,443 - 2,398,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMTC2
20381 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 3 20 2
Low 7 4 5 2 3 2 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000029091   ⟹   ENSSSCP00000019935
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl598,697,017 - 99,085,389 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000029567   ⟹   ENSSSCP00000025563
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl598,830,101 - 99,085,079 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000076068   ⟹   ENSSSCP00000066124
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl598,697,035 - 99,229,550 (-)Ensembl
RefSeq Acc Id: XM_021093031   ⟹   XP_020948690
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1598,695,404 - 99,085,243 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020948690   ⟸   XM_021093031
- UniProtKB: A0A480I5V5 (UniProtKB/TrEMBL),   A0A4X1V3W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000025563   ⟸   ENSSSCT00000029567
RefSeq Acc Id: ENSSSCP00000019935   ⟸   ENSSSCT00000029091
RefSeq Acc Id: ENSSSCP00000066124   ⟸   ENSSSCT00000076068
Protein Domains
DUF1736


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024065 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015001171 UniProtKB/TrEMBL
  ENSSSCG00025041704 UniProtKB/TrEMBL
  ENSSSCG00030066184 UniProtKB/TrEMBL
  ENSSSCG00035032443 UniProtKB/TrEMBL
  ENSSSCG00045035691 UniProtKB/TrEMBL
  ENSSSCG00050063662 UniProtKB/TrEMBL
  ENSSSCG00055025472 UniProtKB/TrEMBL
  ENSSSCG00060008968 UniProtKB/TrEMBL
  ENSSSCG00065021304 UniProtKB/TrEMBL
  ENSSSCG00070021201 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000029567.4 UniProtKB/TrEMBL
  ENSSSCT00000076068 ENTREZGENE
  ENSSSCT00000076068.1 UniProtKB/TrEMBL
  ENSSSCT00015001375.1 UniProtKB/TrEMBL
  ENSSSCT00025056933.1 UniProtKB/TrEMBL
  ENSSSCT00030092516.1 UniProtKB/TrEMBL
  ENSSSCT00035042996.1 UniProtKB/TrEMBL
  ENSSSCT00045061356.1 UniProtKB/TrEMBL
  ENSSSCT00050086718.1 UniProtKB/TrEMBL
  ENSSSCT00055050598.1 UniProtKB/TrEMBL
  ENSSSCT00060011560.1 UniProtKB/TrEMBL
  ENSSSCT00065028354.1 UniProtKB/TrEMBL
  ENSSSCT00070042165.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro DUF1736 UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
NCBI Gene TMTC2 ENTREZGENE
PANTHER PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 UniProtKB/TrEMBL
  PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 UniProtKB/TrEMBL
Pfam DUF1736 UniProtKB/TrEMBL
  TPR_12 UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
  TPR_REGION UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A480I5V5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V3W5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QN86_PIG UniProtKB/TrEMBL
  I3LN91_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94242 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 TMTC2  transmembrane O-mannosyltransferase targeting cadherins 2  TMTC2  transmembrane and tetratricopeptide repeat containing 2  Symbol and/or name change 5135510 APPROVED