ARHGAP27 (Rho GTPase activating protein 27) - Rat Genome Database

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Gene: ARHGAP27 (Rho GTPase activating protein 27) Sus scrofa
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Symbol: ARHGAP27
Name: Rho GTPase activating protein 27
RGD ID: 14166038
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN receptor-mediated endocytosis (ortholog); Rho protein signal transduction (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rho GTPase-activating protein 27
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,037,138 - 18,082,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,037,007 - 18,069,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,203,777 - 18,311,008 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARHGAP27
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,037,138 - 18,082,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,037,007 - 18,069,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,203,777 - 18,311,008 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP27
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381745,393,908 - 45,432,870 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1745,393,902 - 45,434,421 (-)EnsemblGRCh38hg38GRCh38
GRCh371743,471,274 - 43,510,236 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,827,058 - 40,858,780 (-)NCBINCBI36Build 36hg18NCBI36
Build 341740,827,057 - 40,858,780NCBI
Celera1740,180,571 - 40,212,381 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1739,231,827 - 39,270,972 (-)NCBIHuRef
CHM1_11743,706,462 - 43,745,499 (-)NCBICHM1_1
T2T-CHM13v2.01746,247,641 - 46,286,582 (-)NCBIT2T-CHM13v2.0
Arhgap27
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,222,310 - 103,254,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,222,323 - 103,254,518 (-)EnsemblGRCm39 Ensembl
GRCm3811103,331,484 - 103,363,692 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,331,497 - 103,363,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711103,192,814 - 103,206,016 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,147,590 - 103,160,792 (-)NCBIMGSCv36mm8
Celera11115,042,778 - 115,055,972 (-)NCBICelera
Cytogenetic Map11E1NCBI
Arhgap27
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,780,527 - 88,813,275 (-)NCBIGRCr8
mRatBN7.21088,280,470 - 88,313,225 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,280,455 - 88,313,185 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,317,881 - 93,346,423 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,784,855 - 92,813,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,178,203 - 88,206,822 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,418,535 - 91,451,831 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,419,912 - 91,448,477 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,184,970 - 91,218,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41092,522,546 - 92,551,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11092,536,915 - 92,565,710 (-)NCBI
Celera1086,982,503 - 87,011,039 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Arhgap27
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545118,012,982 - 18,022,060 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545118,012,050 - 18,040,013 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP27
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,404,581 - 19,443,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,373,332 - 21,412,446 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01711,894,453 - 11,933,618 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,073,469 - 12,105,357 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,069,342 - 12,105,357 (+)Ensemblpanpan1.1panPan2
ARHGAP27
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,185,580 - 18,196,622 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha917,570,028 - 17,582,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0918,838,868 - 18,869,533 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl918,838,699 - 18,870,311 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1917,735,734 - 17,748,780 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.0918,001,664 - 18,082,117 (+)NCBIUU_Cfam_GSD_1.0
Arhgap27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,509,188 - 17,544,156 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,650,413 - 1,683,824 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,650,704 - 1,685,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP27
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11660,984,171 - 61,020,579 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1660,985,548 - 61,020,220 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607731,720,641 - 31,760,633 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap27
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795106,694 - 121,120 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479588,650 - 140,578 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGAP27
1157 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000018864   ⟹   ENSSSCP00000018360
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1218,037,138 - 18,082,348 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000043205   ⟹   ENSSSCP00000050413
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1218,045,130 - 18,069,985 (+)Ensembl
RefSeq Acc Id: XM_013980870   ⟹   XP_013836324
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11218,056,280 - 18,069,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021066832   ⟹   XP_020922491
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11218,037,015 - 18,069,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021066833   ⟹   XP_020922492
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11218,037,009 - 18,069,989 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021066834   ⟹   XP_020922493
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11218,037,007 - 18,069,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021066835   ⟹   XP_020922494
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11218,045,088 - 18,069,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021066836   ⟹   XP_020922495
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11218,045,057 - 18,069,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021066837   ⟹   XP_020922496
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11218,059,104 - 18,069,987 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020922493   ⟸   XM_021066834
- Peptide Label: isoform X1
- UniProtKB: A0A8D1HGX3 (UniProtKB/TrEMBL),   A0A8D1PQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020922492   ⟸   XM_021066833
- Peptide Label: isoform X1
- UniProtKB: A0A8D1HGX3 (UniProtKB/TrEMBL),   A0A8D1PQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020922491   ⟸   XM_021066832
- Peptide Label: isoform X1
- UniProtKB: A0A8D1HGX3 (UniProtKB/TrEMBL),   A0A8D1PQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020922495   ⟸   XM_021066836
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020922494   ⟸   XM_021066835
- Peptide Label: isoform X2
- UniProtKB: A0A8D1H7V7 (UniProtKB/TrEMBL),   A0A8D0S1Q9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013836324   ⟸   XM_013980870
- Peptide Label: isoform X2
- UniProtKB: A0A8D1H7V7 (UniProtKB/TrEMBL),   A0A8D0S1Q9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020922496   ⟸   XM_021066837
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSSSCP00000018360   ⟸   ENSSSCT00000018864
Ensembl Acc Id: ENSSSCP00000050413   ⟸   ENSSSCT00000043205
Protein Domains
PH   Rho-GAP   SH3   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017328 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015033780 UniProtKB/TrEMBL
  ENSSSCG00025043462 UniProtKB/TrEMBL
  ENSSSCG00030054791 UniProtKB/TrEMBL
  ENSSSCG00040006501 UniProtKB/TrEMBL
  ENSSSCG00045012802 UniProtKB/TrEMBL
  ENSSSCG00050044218 UniProtKB/TrEMBL
  ENSSSCG00055006460 UniProtKB/TrEMBL
  ENSSSCG00060031182 UniProtKB/TrEMBL
  ENSSSCG00065025499 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018864 ENTREZGENE
  ENSSSCT00000018864.5 UniProtKB/TrEMBL
  ENSSSCT00000043205 ENTREZGENE
  ENSSSCT00000043205.2 UniProtKB/TrEMBL
  ENSSSCT00015044762.1 UniProtKB/TrEMBL
  ENSSSCT00015044826.1 UniProtKB/TrEMBL
  ENSSSCT00015044943.1 UniProtKB/TrEMBL
  ENSSSCT00025058945.1 UniProtKB/TrEMBL
  ENSSSCT00025059183.1 UniProtKB/TrEMBL
  ENSSSCT00025059479.1 UniProtKB/TrEMBL
  ENSSSCT00030076542.1 UniProtKB/TrEMBL
  ENSSSCT00030076587.1 UniProtKB/TrEMBL
  ENSSSCT00030076606.1 UniProtKB/TrEMBL
  ENSSSCT00030076615.1 UniProtKB/TrEMBL
  ENSSSCT00040008553.1 UniProtKB/TrEMBL
  ENSSSCT00040008564.1 UniProtKB/TrEMBL
  ENSSSCT00040008577.1 UniProtKB/TrEMBL
  ENSSSCT00045021813.1 UniProtKB/TrEMBL
  ENSSSCT00045021827.1 UniProtKB/TrEMBL
  ENSSSCT00045021852.1 UniProtKB/TrEMBL
  ENSSSCT00050060195.1 UniProtKB/TrEMBL
  ENSSSCT00050060199.1 UniProtKB/TrEMBL
  ENSSSCT00050060205.1 UniProtKB/TrEMBL
  ENSSSCT00055012511.1 UniProtKB/TrEMBL
  ENSSSCT00055012566.1 UniProtKB/TrEMBL
  ENSSSCT00055012625.1 UniProtKB/TrEMBL
  ENSSSCT00060042179.1 UniProtKB/TrEMBL
  ENSSSCT00065034117.1 UniProtKB/TrEMBL
  ENSSSCT00065034126.1 UniProtKB/TrEMBL
  ENSSSCT00065034135.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  2.20.70.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  Rho-GAP UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100628007 UniProtKB/TrEMBL
NCBI Gene ARHGAP27 ENTREZGENE
PANTHER PTHR23176:SF104 UniProtKB/TrEMBL
  RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF50998 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
UniProt A0A287B2D9_PIG UniProtKB/TrEMBL
  A0A8D0NF77_PIG UniProtKB/TrEMBL
  A0A8D0S1Q9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CCU0_PIG UniProtKB/TrEMBL
  A0A8D1D8Q3_PIG UniProtKB/TrEMBL
  A0A8D1H7V7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HAP4_PIG UniProtKB/TrEMBL
  A0A8D1HGX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PQ86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TGD5_PIG UniProtKB/TrEMBL
  F1RR27_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85466 ENTREZGENE