LGSN (lengsin, lens protein with glutamine synthetase domain) - Rat Genome Database

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Gene: LGSN (lengsin, lens protein with glutamine synthetase domain) Sus scrofa
Analyze
Symbol: LGSN
Name: lengsin, lens protein with glutamine synthetase domain
RGD ID: 14156233
Description: ASSOCIATED WITH genetic disease (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lengsin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,360,774 - 82,387,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,360,058 - 82,388,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2192,641,343 - 92,671,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LGSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,360,774 - 82,387,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,360,058 - 82,388,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2192,641,343 - 92,671,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38663,275,951 - 63,573,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl663,275,951 - 63,319,983 (-)EnsemblGRCh38hg38GRCh38
GRCh37663,985,856 - 64,029,888 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36664,047,515 - 64,087,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 34664,047,520 - 64,087,841NCBI
Celera662,145,321 - 62,189,340 (-)NCBICelera
Cytogenetic Map6q12NCBI
HuRef661,165,803 - 61,209,830 (-)NCBIHuRef
CHM1_1664,152,120 - 64,196,163 (-)NCBICHM1_1
T2T-CHM13v2.0664,421,831 - 64,588,322 (-)NCBIT2T-CHM13v2.0
Lgsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39131,215,362 - 31,243,806 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl131,215,482 - 31,243,806 (+)EnsemblGRCm39 Ensembl
GRCm38131,176,281 - 31,204,725 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl131,176,401 - 31,204,725 (+)EnsemblGRCm38mm10GRCm38
MGSCv37131,233,280 - 31,261,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36131,120,981 - 31,149,271 (+)NCBIMGSCv36mm8
Celera130,973,296 - 31,001,446 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map111.53NCBI
Lgsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8940,912,398 - 40,943,955 (+)NCBIGRCr8
mRatBN7.2933,416,362 - 33,447,919 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl933,420,484 - 33,447,907 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx941,913,213 - 41,940,643 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0947,045,193 - 47,072,615 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0945,327,050 - 45,354,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0937,458,603 - 37,490,117 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl937,462,693 - 37,490,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0936,263,149 - 36,294,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4929,844,176 - 29,871,557 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1929,845,589 - 29,872,970 (+)NCBI
Celera931,238,716 - 31,265,934 (+)NCBICelera
Cytogenetic Map9q21NCBI
Lgsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955502483,191 - 552,272 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955502522,492 - 551,842 (+)NCBIChiLan1.0ChiLan1.0
LGSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2578,141,446 - 78,185,404 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1672,801,340 - 72,845,297 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0660,964,873 - 61,008,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1666,235,347 - 66,279,272 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl666,239,052 - 66,280,600 (-)Ensemblpanpan1.1panPan2
LGSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11226,852,832 - 26,884,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1226,852,851 - 26,919,138 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1226,761,476 - 26,792,749 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01227,389,310 - 27,419,270 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1227,389,326 - 27,454,223 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11226,894,374 - 26,924,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01226,976,959 - 27,006,723 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01227,074,028 - 27,103,801 (-)NCBIUU_Cfam_GSD_1.0
Lgsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494662,303,468 - 62,335,915 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364761,624,222 - 1,659,510 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364761,624,287 - 1,656,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11711,419,089 - 11,505,533 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605817,765,855 - 17,806,536 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475321,650,655 - 21,679,764 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475321,645,389 - 21,694,557 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LGSN
697 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system nervous system
High
Medium
Low 3 22
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021084655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000004915   ⟹   ENSSSCP00000004799
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl182,360,774 - 82,382,986 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000047603   ⟹   ENSSSCP00000054534
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl182,360,774 - 82,387,717 (+)Ensembl
RefSeq Acc Id: XM_021084655   ⟹   XP_020940314
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1182,360,058 - 82,388,479 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020940314 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000004799.4
  ENSSSCP00000054534.2
Reference Protein Sequences
RefSeq Acc Id: XP_020940314   ⟸   XM_021084655
- Sequence:
RefSeq Acc Id: ENSSSCP00000004799   ⟸   ENSSSCT00000004915
RefSeq Acc Id: ENSSSCP00000054534   ⟸   ENSSSCT00000047603
Protein Domains
GS beta-grasp   GS catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004450 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004915.5 UniProtKB/TrEMBL
  ENSSSCT00000047603.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.70 UniProtKB/TrEMBL
  Glutamine synthetase/guanido kinase, catalytic domain UniProtKB/TrEMBL
InterPro Gln_synt_N UniProtKB/TrEMBL
  Gln_synt_N UniProtKB/TrEMBL
  Gln_synth/guanido_kin_cat_dom UniProtKB/TrEMBL
  Gln_synth_cat_dom UniProtKB/TrEMBL
NCBI Gene LGSN ENTREZGENE
PANTHER GLUTAMINE SYNTHETASE UniProtKB/TrEMBL
  LENGSIN UniProtKB/TrEMBL
Pfam Gln-synt_C UniProtKB/TrEMBL
PROSITE GS_BETA_GRASP UniProtKB/TrEMBL
  GS_CATALYTIC UniProtKB/TrEMBL
SMART Gln-synt_C UniProtKB/TrEMBL
Superfamily-SCOP SSF54368 UniProtKB/TrEMBL
  SSF55931 UniProtKB/TrEMBL
UniProt A0A287BDY8_PIG UniProtKB/TrEMBL
  F1RX87_PIG UniProtKB/TrEMBL